Capsaicin exhibits neuroprotective effects in a model of transient global cerebral ischemia in Mongolian gerbils.

abstract：BACKGROUND AND PURPOSE:Two of the most relevant unmet needs in epilepsy are represented by the development of disease-modifying drugs able to affect epileptogenesis and/or the study of related neuropsychiatric comorbidities. No systematic study has investigated the effects of chronic treatment with antipsychotics or an...

journal_title：British journal of pharmacology

authors： Citraro R,Leo A,De Fazio P,De Sarro G,Russo E

更新日期：2015-06-01 00:00:00

abstract：:1. The effects of palytoxin (PTX) isolated from Palythoa tubercurosa were tested on the isolated intra-arterially perfused spinal cord of the frog. The resting and evoked potentials were recorded by means of a sucrose-gap technique. 2. PTX caused a marked depolarization of both ventral and dorsal roots. The minimum ef...

journal_title：British journal of pharmacology

authors： Kudo Y,Shibata S

更新日期：1980-01-01 00:00:00

abstract：:1. Rabbit left atrial preparations driven electrically at different rates were used for studies on inotropic effects of cations, drugs and coupled pacing. Sino-atrial node-atrial preparations were used for investigating the chronotropic effect of noradrenaline.2. The contractile tension-driving rate relationship was m...

journal_title：British journal of pharmacology

authors： Toda N

更新日期：1969-06-01 00:00:00

abstract：:1. Prostaglandin E2 (PGE2) is an autacoid that decreases proteoglycan synthesis, increases metalloprotease production by cultured chondrocytes, and can modulate some of the actions of interleukin-1 on cartilage. The objective of the present study was to characterize the subtype of prostaglandin E2 receptor present in ...

journal_title：British journal of pharmacology

authors： de Brum-Fernandes AJ,Morisset S,Bkaily G,Patry C

更新日期：1996-08-01 00:00:00

abstract：:1. Recent studies have shown antagonists at the NK1 subtype of receptor for tachykinins are antiemetics and suggested that this may result from blockade of tachykinin-mediated synaptic transmission at a central site in the emetic reflex. 2. We have used intracellular recording in vitro to study the pharmacology of tac...

journal_title：British journal of pharmacology

authors： Maubach KA,Jones RS

更新日期：1997-11-01 00:00:00

abstract：:Nociceptin (NC), alias Orphanin FQ, has been recently identified as the endogenous ligand of the opioid receptor-like 1 receptor (OP(4)). This new NC/OP(4) receptor system belongs to the opioid family and has been characterized pharmacologically with functional and binding assays on native (mouse, rat, guinea-pig) and...

journal_title：British journal of pharmacology

authors： Calo' G,Guerrini R,Rizzi A,Salvadori S,Regoli D

更新日期：2000-04-01 00:00:00

abstract：:1. The use of pharmacological inhibitors of nitric oxide (NO) synthesis to treat patients with septic shock is limited by the observation that they cause a fall in cardiac output in some subjects. The aim of this work was to investigate this fall and to test whether it was reversible by subsequent administration of ni...

journal_title：British journal of pharmacology

authors： Herity NA,Allen JD,Silke B,Adgey AA

更新日期：1994-06-01 00:00:00

abstract：:1. The role played by endogenous lipocortin 1 in the anti-migratory action exerted by dexamethasone (Dex) on monocyte recruitment in an in vivo model of acute inflammation was investigated by use of several neutralizing polyclonal antibodies raised against lipocortin 1 or a lipocortin 1-derived N-terminus peptide (pep...

journal_title：British journal of pharmacology

authors： Getting SJ,Flower RJ,Perretti M

更新日期：1997-03-01 00:00:00

abstract：:1 ATP is an important vasoactive mediator, which acts via two receptor classes: P2X and P2Y. Activation of P2X receptors has traditionally been associated with the well-characterised vasoconstrictor properties of ATP. 2 In the current study, we have shown that the P2X(1 & 3) receptor ligand, alpha, beta methylene ATP,...

journal_title：British journal of pharmacology

authors： Harrington LS,Mitchell JA

更新日期：2004-11-01 00:00:00

abstract：:1. Bicyclic compounds with potential thymoleptic properties (Lu-compounds) have recently become available, and their effects on the membrane pumps of the central and peripheral monoamine neurones have now been tested and compared with those of the tricyclic antidepressant drugs.2. Biochemical and histochemical in vivo...

journal_title：British journal of pharmacology

authors： Carlsson A,Fuxe K,Hamberger B,Malmfors T

更新日期：1969-05-01 00:00:00

abstract：:Pulmonary fibrosis represents the end stage of a number of heterogeneous conditions and is, to a greater or lesser degree, the hallmark of the interstitial lung diseases. It is characterized by the excessive deposition of extracellular matrix proteins within the pulmonary interstitium leading to the obliteration of fu...

journal_title：British journal of pharmacology

authors： Datta A,Scotton CJ,Chambers RC

更新日期：2011-05-01 00:00:00

abstract：:1. S 16257 is a new bradycardic agent. Its electropharmacological profile has been compared to that of the known bradycardic compound UL-FS 49 (Zatebradine). Intracellular recordings of action potentials (APs) were performed with conventional glass microelectrodes. 2. In the rabbit isolated sino-atrial node (SAN) tiss...

journal_title：British journal of pharmacology

authors： Thollon C,Cambarrat C,Vian J,Prost JF,Peglion JL,Vilaine JP

更新日期：1994-05-01 00:00:00

abstract：:We investigated whether 10 days' in vivo treatment with nitroglycerine (NTG) would inhibit nitric oxide production by the endothelial cells of resistance arteries ex vivo and, if so, what the underlying mechanism might be. ACh increased the intracellular nitric oxide concentration ([NO]i; estimated using the nitric ox...

journal_title：British journal of pharmacology

authors： Yamamoto T,Kajikuri J,Watanabe Y,Suzuki Y,Suzumori K,Itoh T

更新日期：2005-10-01 00:00:00

abstract：:1. The effects of inhibiting endogenous Cu/Zn superoxide dismutase (SOD) with diethyldithiocarbamate (DETCA) were examined on the ability of hydroquinone, hydroxocobalamin and carboxy-PTIO to block nitrergic relaxation in the bovine retractor penis (BRP) muscle. 2. Incubation of strips of BRP with DETCA (3 mM) for 2 h...

journal_title：British journal of pharmacology

authors： Paisley K,Martin W

更新日期：1996-04-01 00:00:00

abstract：:1. When injected intraperitoneally into mice in doses larger than those used clinically, all the amino derivatives of bisphosphonates (aminoBPs) tested induce a variety of inflammatory reactions such as induction of histidine decarboxylase (HDC, the histamine-forming enzyme), hypertrophy of the spleen, atrophy of the ...

journal_title：British journal of pharmacology

authors： Endo Y,Shibazaki M,Yamaguchi K,Nakamura M,Kosugi H

更新日期：1999-02-01 00:00:00

abstract：:1. The effects of pinacidil on noradrenaline-induced tone, smooth muscle membrane potential and 42K- and 86Rb-efflux from isolated mesenteric resistance vessels (internal diameter 200 microns) of the rat have been studied. 2. Pinacidil (0.3-10 microM) produced concentration-dependent suppression of noradrenaline-induc...

journal_title：British journal of pharmacology

authors： Videbaek LM,Aalkjaer C,Mulvany MJ

更新日期：1988-09-01 00:00:00

abstract：:Oxidized ATP (oATP) is a Schiff-base-forming reagent that has been used for some years as an antagonist at the P2X7 receptor (P2X7R). Preincubation of mononuclear phagocytes with this inhibitor leads to attenuation of several proinflammatory responses triggered by extracellular ATP as well as a few non-nucleotide agon...

journal_title：British journal of pharmacology

authors： Di Virgilio F

更新日期：2003-10-01 00:00:00

abstract：:1. We aimed to determine whether nitric oxide (NO) and/or the endothelium is involved in cholinergic neurogenic vasodilatation in the rat isolated hindquarters. 2. The abdominal aorta was cannulated for perfusion of the rat hindquarters with Krebs bicarbonate solution containing phenylephrine, to induce basal constric...

journal_title：British journal of pharmacology

authors： Loke KE,Sobey CG,Dusting GJ,Woodman OL

更新日期：1994-06-01 00:00:00

abstract：:1. The effects of lifarizine (RS-87476) on intracellular Ca2+ rises and the release of glutamate from rat cerebrocortical synaptosomes depolarized with 30 mM KCl were investigated by use of entrapped fura 2 and exogenous glutamate dehydrogenase. 2. Prior (1 min) addition of lifarizine decreased 30 mM KCl-induced total...

journal_title：British journal of pharmacology

authors： Budd DC,May GR,Nicholls DG,McCormack JG

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Hydrogen sulphide (H2 S) is an endogenous gaseous signalling molecule with putative functions in gastrointestinal motility regulation. Characterization of H2 S effects on colonic motility is crucial to establish its potential use as therapeutic agent in the treatment of colonic disorders. EXPERI...

journal_title：British journal of pharmacology

authors： Gil V,Parsons S,Gallego D,Huizinga J,Jimenez M

更新日期：2013-05-01 00:00:00

abstract：:1. The effects of adenosine A1 receptor stimulation on basal and histamine-stimulated levels of intracellular free calcium ion concentration ([Ca2+]i) have been investigated in primary astrocyte cultures derived from neonatal rat forebrains. 2. Histamine (0.1 microM-1 mM) caused rapid, concentration-dependent increase...

journal_title：British journal of pharmacology

authors： Peakman MC,Hill SJ

更新日期：1995-07-01 00:00:00

abstract：:1 Burimamide injected intravenously in the anaesthetized or conscious cat produced significant increases in gastric acid secretion: in the anaesthetized cat it produced increased gastric mucosal blood flow. 2 Metiamide, in doses which inhibited pentagastrin-stimulated acid secretion, produced no increase in gastric ac...

journal_title：British journal of pharmacology

authors： Harris DW,Smy JR,Reed JD,Venables CW

更新日期：1975-02-01 00:00:00

abstract：:1. A study was made to exclude the notion that adenosine receptor agonists exert a direct physical blockade of the depolarization-secretion process. Reduced temperature was employed as a tool for distinguishing between physico-chemical processes (such as those which mediate evoked transmitter release) and biochemical ...

journal_title：British journal of pharmacology

authors： Silinsky EM,Hirsh JK

更新日期：1988-04-01 00:00:00

abstract：:1. By use of patch-clamp techniques, the effects of SD-3212, a novel antiarrhythmic drug, on the calcium current (Ica), the sodium current (INa) and the muscarinic acetylcholine-receptor-operated potassium current (IK.ACh) were examined and compared with those of bepridil in guinea-pig single atrial cells. 2. SD-3212 ...

journal_title：British journal of pharmacology

authors： Hara Y,Nakaya H

更新日期：1995-11-01 00:00:00

abstract：:1 We previously reported that four lignans isolated from the bark of Machilus thunbergii Sieb. et Zucc. (Lauraceae) protected primary cultures of rat cortical neurons from neurotoxicity induced by glutamate. 2 Among the lignans, meso-dihydroguaiarectic acid (MDGA) and licarin A significantly attenuated glutamate-induc...

journal_title：British journal of pharmacology

authors： Ma CJ,Kim SR,Kim J,Kim YC

更新日期：2005-11-01 00:00:00

abstract：:Fresh human erythrocytes were washed and incubated at 37 degrees C in physiological saline buffered with Tris, containing calcium and either neuraminidase or trypsin or both enzymes together. Each enzyme alone, as well as both together, released similar amounts of sialic acids without haemolysis, apparently therefore ...

journal_title：British journal of pharmacology

authors： Born GV,Housley GM

更新日期：1983-06-01 00:00:00

abstract：:There is evidence that cannabinoid-based medicines that are selective for different targets in the cannabinoid signalling system (e.g. receptors, inactivation mechanism, enzymes) might be beneficial in basal ganglia disorders, namely Parkinson's disease (PD) and Huntington's disease (HD). These benefits not only inclu...

journal_title：British journal of pharmacology

authors： Fernández-Ruiz J

更新日期：2009-04-01 00:00:00

abstract：:1. During the past few years it has been shown that the sympatholytic effect resulting from localized microinjection of clonidine and other imidazolines into the rostral ventrolateral medulla (RVL) results from activation of 'imidazoline' receptors (I1 receptors) rather than from an alpha 2-adrenoceptor-mediated effec...

journal_title：British journal of pharmacology

authors： Hieble JP,Kolpak DC

更新日期：1993-12-01 00:00:00

abstract：:1. It has been reported previously that the milrinone analogues, ethyl 5-cyano-1,6-dihydro-2-methyl-6-oxo-3 pyridine carboxylate (I) and ethyl 5-cyano-1,6-dihydro-2-ethyl-6-oxo-3 pyridine carboxylate (II) exert a positive inotropic effect (EC50 = 15.6 +/- 0.2 microM and 40.3 +/- 0.1 microM) both on spontaneously beati...

journal_title：British journal of pharmacology

authors： Dorigo P,Gaion RM,Belluco P,Mosti L,Borea PA,Maragno I

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We recently reported that AAV1-Rheb(S16H) transduction could protect hippocampal neurons through the induction of brain-derived neurotrophic factor (BDNF) in the rat hippocampus in vivo. It is still unclear how neuronal BDNF produced by AAV1-Rheb(S16H) transduction induces neuroprotective effects...

journal_title：British journal of pharmacology

authors： Jeon MT,Moon GJ,Kim S,Choi M,Oh YS,Kim DW,Kim HJ,Lee KJ,Choe Y,Ha CM,Jang IS,Nakamura M,McLean C,Chung WS,Shin WH,Lee SG,Kim SR

更新日期：2020-02-01 00:00:00