Inhibition by lifarizine of intracellular Ca2+ rises and glutamate exocytosis in depolarized rat cerebrocortical synaptosomes and cultured neurones.

abstract：:Almost all existing models for G-protein-coupled receptors (GPCRs) are based on the occurrence of monomers. Recent studies show that many GPCRs are dimers. Therefore for some receptors dimers and not monomers are the main species interacting with hormones/neurotransmitters/drugs. There are reasons for equivocal interp...

journal_title：British journal of pharmacology

authors： Franco R,Casadó V,Cortés A,Mallol J,Ciruela F,Ferré S,Lluis C,Canela EI

更新日期：2008-03-01 00:00:00

abstract：:1. The effects of forskolin, prostaglandin E1 (PGE1), dibutyryl cyclic AMP (db cyclic AMP), dibutyryl cyclic GMP (db cyclic GMP) and 3-isobutyl-l-methyl-xanthine (IBMX) were investigated on the expression of tissue factor and thrombomodulin activities on the surface of human saphenous vein endothelial cells (HSVEC) in...

journal_title：British journal of pharmacology

authors： Archipoff G,Beretz A,Bartha K,Brisson C,de la Salle C,Froget-Léon C,Klein-Soyer C,Cazenave JP

更新日期：1993-05-01 00:00:00

abstract：:1 We investigated the neuritogenic action of nitric oxide (NO)-generating agents and their mechanisms of action in a subclone of rat pheochromocytoma, PC12h cells. 2 NO donors such as sodium nitroprusside (SNP, 0.05-1 microM), NOR1 (5-100 microM), NOR2 (5-20 microM), NOR3 (5-20 microM), NOR4 (5-100 microM), or S-nitro...

journal_title：British journal of pharmacology

authors： Yamazaki M,Chiba K,Mohri T

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Postsystolic wall thickening (PSWT) is part of thickening that occurs after end-systole and represents wasted effort as it does not contribute to ejection. The effects of antianginal drugs on PSWT remain to be established. We compared the effects on PSWT of two agents that reduce heart rate, the ...

journal_title：British journal of pharmacology

authors： Lucats L,Ghaleh B,Colin P,Monnet X,Bizé A,Berdeaux A

更新日期：2007-02-01 00:00:00

abstract：:In recent years there has been a growing recognition of the influence of sex on brain structure and function, and in relation, on the susceptibility, prevalence and response to treatment of psychiatric disorders. Most theories and descriptions of the effects of sex on the brain are dominated by an analogy to the curre...

journal_title：British journal of pharmacology

authors： Joel D,Yankelevitch-Yahav R

更新日期：2014-10-01 00:00:00

abstract：:1. Using gene chip technology, we first identified that PGF(2alpha) (FP agonist) and Butaprost (EP(2) agonist) induced about a five-fold upregulation of Nur77 mRNA expression in hFP-HEK 293/EBNA and hEP(2)-HEK293/EBNA cells. Northern Blot analysis revealed that PGF(2alpha)- and Butaprost-induced upregulation of Nur77 ...

journal_title：British journal of pharmacology

authors： Liang Y,Li C,Guzman VM,Chang WW,Evinger AJ,Pablo JV,Woodward DF

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The type-5 PDE inhibitor vardenafil reduces myocardial infarct size in situ, following ischemia/reperfusion, when applied at reperfusion in animal models. Little is known about the underlying protective signaling. Here, we test whether vardenafil is protective in rat isolated hearts and in a cell...

journal_title：British journal of pharmacology

authors： Maas O,Donat U,Frenzel M,Rütz T,Kroemer HK,Felix SB,Krieg T

更新日期：2008-05-01 00:00:00

abstract：:1. Fluoxetine (Prozac) is widely used as an antidepressant drug and is assumed to be a selective 5-hydroxytryptamine (5-HT) reuptake inhibitor (SSRI). Claims that its beneficial psychotropic effects extend beyond those in treatment of depression have drawn clinical and popular attention to this compound, raising the q...

journal_title：British journal of pharmacology

authors： Tytgat J,Maertens C,Daenens P

更新日期：1997-12-01 00:00:00

abstract：:Recent advances have improved our understanding of the renin-angiotensin system (RAS). These have included the recognition that angiotensin (Ang)-(1-7) is a biologically active product of the RAS cascade. The identification of the ACE homologue ACE2, which forms Ang-(1-7) from Ang II, and the GPCR Mas as an Ang-(1-7) ...

journal_title：British journal of pharmacology

authors： Simões e Silva AC,Silveira KD,Ferreira AJ,Teixeira MM

更新日期：2013-06-01 00:00:00

abstract：:1. The pharmacological characteristics of cloned mammalian alpha 1A/D-, alpha 1B- and alpha 1C-adrenoceptor subtypes expressed in rat 1 fibroblasts were determined in comparison to the binding and functional properties of these subtypes in rat tissues. 2. Analysis of [3H]-prazosin binding to membrane homogenates from ...

journal_title：British journal of pharmacology

authors： Kenny BA,Naylor AM,Greengrass PM,Russell MJ,Friend SJ,Read AM,Wyllie MG

更新日期：1994-04-01 00:00:00

abstract：:1 The concept that nitric oxide (NO) release can be beneficial in inflammatory conditions has raised more attention in the recent years, particularly with the development of nitric oxide-releasing anti-inflammatory drugs. There is considerable evidence that NO is capable of enhancing the anti-inflammatory benefits of ...

journal_title：British journal of pharmacology

authors： Hyun E,Bolla M,Steinhoff M,Wallace JL,Soldato PD,Vergnolle N

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Caffeine is one of the most commonly used psychoactive substances. Circadian rhythms consist of the main suprachiasmatic nucleus (SCN) clocks and peripheral clocks. Although caffeine lengthens circadian rhythms and modifies phase changes in SCN-operated rhythms, the effects on caffeine on the pha...

journal_title：British journal of pharmacology

authors： Narishige S,Kuwahara M,Shinozaki A,Okada S,Ikeda Y,Kamagata M,Tahara Y,Shibata S

更新日期：2014-12-01 00:00:00

abstract：:1. The effects of a series of nine GABAB receptor antagonists of widely varying potencies on electrically stimulated release from cortical slices of [3H]-GABA in the absence or presence of 10 microM of the GABAB agonist, (-)-baclofen and of endogenous glutamate in the presence of (-)-baclofen were compared. 2. The con...

journal_title：British journal of pharmacology

authors： Waldmeier PC,Wicki P,Feldtrauer JJ,Mickel SJ,Bittiger H,Baumann PA

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Angiotensin AT1 receptor antagonists induce weight loss; however, the mechanism underlying this phenomenon is unknown. The Mas receptor agonist angiotensin-(1-7) is a metabolite of angiotensin I and of angiotensin II . As an agonist of Mas receptors, angiotensin-(1-7) has beneficial cardiovascula...

journal_title：British journal of pharmacology

authors： Schuchard J,Winkler M,Stölting I,Schuster F,Vogt FM,Barkhausen J,Thorns C,Santos RA,Bader M,Raasch W

更新日期：2015-08-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a complex disease characterized by elevated pulmonary arterial pressure, pulmonary vascular remodelling and occlusive pulmonary vascular lesions, leading to right heart failure. Evidence from recent epidemiological studies suggests the influence of gender on the development of ...

journal_title：British journal of pharmacology

authors： Mair KM,Johansen AK,Wright AF,Wallace E,MacLean MR

更新日期：2014-02-01 00:00:00

abstract：:Eotaxin is a novel C-C chemokine with selective chemoattractant activity for eosinophils. We determined whether eotaxin could be produced by human airway smooth muscle (HASM) cells in culture and examined its regulation by interleukin-10 (IL-10) and the corticosteroid, dexamethasone. Stimulation of the cells with inte...

journal_title：British journal of pharmacology

authors： Chung KF,Patel HJ,Fadlon EJ,Rousell J,Haddad EB,Jose PJ,Mitchell J,Belvisi M

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The passage of drugs across the blood-brain barrier (BBB) limits the efficacy of chemotherapy in brain tumours. For instance, the anticancer drug doxorubicin, which is effective against glioblastoma in vitro, has poor efficacy in vivo, because it is extruded by P-glycoprotein (Pgp/ABCB1), multidr...

journal_title：British journal of pharmacology

authors： Pinzón-Daza M,Garzón R,Couraud P,Romero Ia,Weksler B,Ghigo D,Bosia A,Riganti C

更新日期：2012-12-01 00:00:00

abstract：:The ability of beta-adrenoceptor agonists to reduce the fusion of incomplete tetanic contractions of the soleus muscle of the cat has been used previously as a model to assess the potential tremor producing effect of sympathomimetic bronchodilators. The ability of (-)-isoprenaline, (-)-adrenaline, (+/-)-soterenol and ...

journal_title：British journal of pharmacology

authors： Nott MW,Raper C

更新日期：1972-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Montelukast and S-carbocysteine have been used in asthmatic patients as an anti-inflammatory or mucolytic agent respectively. S-carbocysteine also exhibits anti-inflammatory properties. EXPERIMENTAL APPROACH:Ovalbumin (OVA) sensitized BALB/c mice were challenged with OVA for 3 days followed by s...

journal_title：British journal of pharmacology

authors： Takeda K,Shiraishi Y,Matsubara S,Miyahara N,Matsuda H,Okamoto M,Joetham A,Gelfand EW

更新日期：2010-07-01 00:00:00

abstract：:1. The degree to which the RhoA kinase (ROK) blockers, Y-27632 (1 micro M) and HA-1077 (10 micro M), and the PKC blocker, GF-109203X (1 micro M), reduced force produced by carbachol, a muscarinic receptor agonist, and phenylephrine, an alpha-adrenoceptor agonist, was examined in rabbit stomach fundus smooth muscle. 2....

journal_title：British journal of pharmacology

authors： Ratz PH,Meehl JT,Eddinger TJ

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Strontium ranelate reduces fracture risk in postmenopausal women with osteoporosis. Evidence from non-clinical studies and analyses of bone markers in phase III trials indicate that this is due to an increase in osteoblast formation and a decrease of osteoclastic resorption. The aim of this work ...

journal_title：British journal of pharmacology

authors： Brennan TC,Rybchyn MS,Green W,Atwa S,Conigrave AD,Mason RS

更新日期：2009-08-01 00:00:00

abstract：:1 Peptide 401, a potent mast cell degranulating factor from bee venom, substantially inhibited the oedema provoked by subplantar injection of carrageenin or intra-articular injection of turpentine in the rat. The ED(50) of 401 was c. 0.1 mg/kg. The anti-inflammatory effect was assessed by measurement of the increased ...

journal_title：British journal of pharmacology

authors： Hanson JM,Morley J,Soria-Herrera C

更新日期：1974-03-01 00:00:00

abstract：:1. We have taken advantage of our recent development of highly potent and specific phosphinic inhibitors of endopeptidase 3.4.24.15 to examine the putative contribution of the enzyme in the secretion of A beta by HK293 transfected cells overexpressing the wild type and the Swedish (Sw) double mutated form of beta APP7...

journal_title：British journal of pharmacology

authors： Chevallier N,Jiracek J,Vincent B,Baur CP,Spillantini MG,Goedert M,Dive V,Checler F

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Due to their potent bronchodilator properties, beta(2)-adrenoceptor agonists are a mainstay of therapy in asthma. However, the effects of beta(2)-adrenoceptor agonists on inflammation are less clear. Accordingly, we have investigated the effects of beta(2)-adrenoceptor agonists on inflammatory me...

journal_title：British journal of pharmacology

authors： Holden NS,Rider CF,Bell MJ,Velayudhan J,King EM,Kaur M,Salmon M,Giembycz MA,Newton R

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:A putative novel cannabinoid receptor mediates vasorelaxation to anandamide and abnormal-cannabidiol and is blocked by O-1918 and by high concentrations of rimonabant. This study investigates VSN16, a novel water-soluble agonist, as a vasorelaxant potentially acting at non-CB1, non-CB2 cannabinoi...

journal_title：British journal of pharmacology

authors： Hoi PM,Visintin C,Okuyama M,Gardiner SM,Kaup SS,Bennett T,Baker D,Selwood DL,Hiley CR

更新日期：2007-11-01 00:00:00

abstract：:1. In circular muscle strips of the fundus and corpus of guinea-pig stomach, mechanical responses to catecholamines were studied mainly in the presence of a prostaglandin biosynthesis inhibitor, meclofenamate. 2. Normal preparations developed considerable muscle tone, and adrenaline (10-100 microM) in the presence of ...

journal_title：British journal of pharmacology

authors： Syed MM,Parekh AB,Tomita T

更新日期：1990-12-01 00:00:00

abstract：:1. Morphine-like analgesic drugs caused depression of twitches of the isolated guinea-pig ileum in response to transmural electrical stimulation. The drugs tested were the narcotic analgesics codeine, diamorphine, fentanyl, morphine, morphine-N-oxide, normorphine, oxymorphone, pethidine, phenazocine and phenoperidine ...

journal_title：British journal of pharmacology

authors： Fennessy MR,Heimans RL,Rand MJ

更新日期：1969-10-01 00:00:00

abstract：:Since its discovery over 50 years ago, cAMP has been the archetypal second messenger introducing students to the concept of cell signalling at the simplest level. As explored in this review, however, there are many more facets to cAMP signalling than the path from Gs-coupled receptor to adenylyl cyclase (AC) to cAMP t...

journal_title：British journal of pharmacology

authors： Billington CK,Hall IP

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:As the pathogenesis of postoperative ileus (POI) involves inflammation and oxidative stress, comparable to ischaemia/reperfusion injury which can be ameliorated with nitrite, we investigated whether nitrite can protect against POI and explored the mechanisms involved. EXPERIMENTAL APPROACH:We us...

journal_title：British journal of pharmacology

authors： Cosyns SM,Shiva S,Lefebvre RA

更新日期：2015-10-01 00:00:00

abstract：:1 A study was made of desensitization in chronically denervated and in normally innervated mouse soleus muscles. 2 Very high concentrations of acetylcholine produced small contractions of the innervated muscles; these were reduced in size when the addition was repeated 1 min after wash-out. 3 Desensitization in innerv...

journal_title：British journal of pharmacology

authors： Hall MT,Maleque MA,Wadsworth RM

更新日期：1975-09-01 00:00:00