Abstract：
BACKGROUND:Atherosclerosis is a chronic progressive disease often presenting as clinical cardiovascular disease (CVD) events. This study evaluated the characteristics of individuals with a diagnosis of atherosclerosis and estimated the incidence of CVD events to assist in the early identification of high-risk individuals. METHODS:Respondents to the US SHIELD baseline survey were followed for 2 years to observe incident self-reported CVD. Respondents had subclinical atherosclerosis if they reported a diagnosis of narrow or blocked arteries/carotid artery disease without a past clinical CVD event (heart attack, stroke or revascularization). Characteristics of those with atherosclerosis and incident CVD were compared with those who did not report atherosclerosis at baseline but had CVD in the following 2 years using chi-square tests. Logistic regression model identified characteristics associated with atherosclerosis and incident events. RESULTS:Of 17,640 respondents, 488 (2.8%) reported having subclinical atherosclerosis at baseline. Subclinical atherosclerosis was associated with age, male gender, dyslipidemia, circulation problems, hypertension, past smoker, and a cholesterol test in past year (OR = 2.2) [all p < 0.05]. Incident CVD was twice as high in respondents with subclinical atherosclerosis (25.8%) as in those without atherosclerosis or clinical CVD (12.2%). In individuals with subclinical atherosclerosis, men (RR = 1.77, p = 0.050) and individuals with circulation problems (RR = 2.36, p = 0.003) were at greatest risk of experiencing CVD events in the next 2 years. CONCLUSION:Self-report of subclinical atherosclerosis identified an extremely high-risk group with a >25% risk of a CVD event in the next 2 years. These characteristics may be useful for identifying individuals for more aggressive diagnostic and therapeutic efforts.
journal_name
BMC Cardiovasc Disordjournal_title
BMC cardiovascular disordersauthors
Robinson JG,Fox KM,Bullano MF,Grandy S,SHIELD Study Group.doi
10.1186/1471-2261-9-46subject
Has Abstractpub_date
2009-09-15 00:00:00pages
46issn
1471-2261pii
1471-2261-9-46journal_volume
9pub_type
杂志文章abstract：BACKGROUND:Fabry disease (FD) is a hereditary metabolic disorder caused by the partial or total inactivation of a lysosomal hydrolase, the enzyme α-galactosidase A (GLA). This inactivation is responsible for the storage of undegraded glycosphingolipids in the lysosomes with subsequent cellular and microvascular dysfunc...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/1471-2261-12-39
更新日期：2012-06-08 00:00:00
abstract：BACKGROUND:Patients requiring anticoagulation suffer from comorbidities such as hypertension. On the occasion of INR monitoring, general practitioners (GPs) have the opportunity to control for blood pressure (BP). We aimed to evaluate the impact of Vitamin-K Antagonist (VKA) monitoring by GPs on BP control in patients ...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-015-0053-x
更新日期：2015-06-10 00:00:00
abstract：BACKGROUND:In a previous study, we found that titrating clopidogrel maintenance doses (MDs) according to vasodilator-stimulated phosphoprotein (VASP) monitoring minimised the rate of major adverse cardiovascular and cerebral events (MACCE) after percutaneous coronary intervention (PCI) without increasing bleeding in pa...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12872-018-0853-x
更新日期：2018-06-18 00:00:00
abstract：BACKGROUND:CYP2C19*2 polymorphism is related to metabolizer phenotypes resulting in reduced effectiveness in converting the antiplatelet drug clopidogrel to active drug. An association of the genotype itself with adverse outcomes is discussed. We investigated the prognostic value of carriage of the CYP2C19*2 allele in ...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/1471-2261-13-61
更新日期：2013-08-27 00:00:00
abstract：BACKGROUND:Depression is common in patients with cardiometabolic diseases but little is known about the relationship, if any, between cardiovascular risk factor values and depressive symptoms in patients with these conditions. The objective of this paper is to study the association between cardiovascular risk factors a...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/1471-2261-14-139
更新日期：2014-10-28 00:00:00
abstract：BACKGROUND:The ten year probability of cardiovascular events can be calculated, but many people are unaware of their risk and unclear how to reduce it. The aim of this study was to assess whether a community based intervention, for men and women aged between 45 and 64 years without pre-existing coronary heart disease, ...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/1471-2261-8-18
更新日期：2008-07-26 00:00:00
abstract：BACKGROUND:Carotid intima-media thickness (C-IMT) is a reliable predictor of cardiovascular events. We Investigated the relationship between markers of glycemia and C-IMT in intermediate-risk cardiovascular patients. METHODS:This study analyzed 427 subjects, aged 35 to 74 years (mean, 60.3 ± 8.5 years), 55 % women, en...
journal_title：BMC cardiovascular disorders
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1186/s12872-016-0380-6
更新日期：2016-10-28 00:00:00
abstract：BACKGROUND:First-degree atrioventricular block (AVB) has traditionally been regarded as a benign condition but recent studies have challenged this conception. Prevalence of 1-2% have been reported in developed countries in Asia. However, no epidemiologic studies have established the prevalence of first-degree AVB in de...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-019-1202-4
更新日期：2019-10-07 00:00:00
abstract：BACKGROUND:Depression often co-exists with non-cardiovascular morbid conditions. Whether this comorbidity increases the risk of cardiovascular disease has so far not been studied. Thus, the aim of this study was to determine if non-cardiovascular morbidity modifies the effect of depression on future risk of CVD. METHO...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-019-1252-7
更新日期：2019-11-21 00:00:00
abstract：BACKGROUND:The previous genome-wide studies have shown that rs7193343 single-nucleotide polymorphism (SNP) in zinc finger homeobox 3 (ZFHX3) gene correlate with risk of atrial fibrillation (AF). However, the distribution of this SNP differs significantly among various populations. The present study was to investigate w...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章,meta分析
doi：10.1186/s12872-015-0044-y
更新日期：2015-06-26 00:00:00
abstract：BACKGROUND:High blood glucose impairs voltage-gated K+ (Kv) channel-mediated vasodilation in rat coronary artery smooth muscle cells (CSMCs) via oxidative stress. Advanced glycation end product (AGE) and receptor for AGE (RAGE) axis has been found to impair coronary dilation by reducing Kv channel activity in diabetic ...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-020-01613-y
更新日期：2020-07-14 00:00:00
abstract：BACKGROUND:Inflammatory cells infiltrate into the ischemic and hypoxic myocardial tissue after myocardial infarction. B cells gather at the site of myocardial injury and secrete cytokines to regulate immune inflammation and fiber repair processes. METHODS:The animal experiment used ligation of the left anterior descen...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-020-01775-9
更新日期：2021-01-06 00:00:00
abstract：BACKGROUND:The identification of new risk factors for coronary artery disease (CAD) is increasingly sought in an effort to tackle this threatening disease. β2-microglobulin (B2M) is reported to associate with peripheral arterial disease and adverse cardiovascular outcomes. However, the association between B2M and cardi...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-017-0502-9
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:Renal denervation (RDN) targeting the sympathetic nerves in the renal arterial adventitia as a treatment of resistant hypertension can cause endothelial injury and vascular wall injury. This study aims to evaluate the risk of atherosclerosis induced by RDN in renal arteries. METHODS:A total of 15 minipigs w...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-020-01472-7
更新日期：2020-04-16 00:00:00
abstract：BACKGROUND:Maximal cardiopulmonary exercise testing (CPX) is the gold-standard for cardiorespiratory fitness assessment in chronic heart failure (CHF) patients. However, high costs, required medical supervision, and safety concerns make maximal exercise testing impractical for evaluating mobility-impaired adults. Thus,...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-018-0801-9
更新日期：2018-04-16 00:00:00
abstract：BACKGROUND:To investigate whether B-type natriuretic peptide (NP)-guided treatment of heart failure (HF) patients improved their health related quality of life (Hr-QoL) compared to routine HF treatment, and whether changes in Hr-QoL differed depending on whether the patient was a responder to NP-guided therapy or not. ...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1186/s12872-016-0221-7
更新日期：2016-02-13 00:00:00
abstract：BACKGROUND:Heart failure (HF) remains a significant cause of morbidity and mortality. Multiple trials over the past several years have examined the effects of both angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) in the treatment of left ventricular dysfunction, both acutely ...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章,meta分析
doi：10.1186/s12872-017-0686-z
更新日期：2017-10-05 00:00:00
abstract：BACKGROUND:Aortic calcification is a major risk factor for death from cardiovascular disease. We investigated the relationship between mortality and the composite markers of number, size, morphology and distribution of calcified plaques in the lumbar aorta. METHODS:308 postmenopausal women aged 48-76 were followed for...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/1471-2261-10-56
更新日期：2010-11-10 00:00:00
abstract：BACKGROUND:Ticagrelor and clopidogrel, P2Y12 receptor antagonists, can prevent thrombotic events and are used to treat cardiovascular diseases such as acute coronary syndrome and chronic obstructive pulmonary disease, in which inflammation is involved. Moreover, NF-B is the central regulator of inflammation. Thus, we s...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-019-01287-1
更新日期：2019-12-30 00:00:00
abstract：BACKGROUND:The aim of the study was to investigate the relationship between the ejection fraction (EF) and the mitral annular systolic velocity (Sm) in patients with preserved left ventricular systolic function (EF>55%). The study task was to evaluate whether the assessment of Sm(avg) can be used as an alternative to t...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章,随机对照试验
doi：10.1186/1471-2261-13-92
更新日期：2013-10-26 00:00:00
abstract：BACKGROUND:Genetic and environment play a significant role in the etiology of essential hypertension (EH). Recently STK39 rs3754777, ATP2B1 rs2681472 and rs17249754 have been associated with BP variation and hypertension. In this study we aimed to determine firstly whether index variants were associated with the risk o...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-019-1136-x
更新日期：2019-06-26 00:00:00
abstract：BACKGROUND:Epicardial adipose tissue (EAT) remodeling and adipocytokines are associated with structural remodeling in atrial fibrillation (AF). However, the role of omentin-1, a novel adipocytokine, in structural remodeling remains unknown. METHODS:Hematoxylin and eosin (H&E) and Masson's trichrome stains were used to...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-020-01478-1
更新日期：2020-05-06 00:00:00
abstract：BACKGROUND:Implantation of left atrial appendage (LAA) occlusion devices was shown to be a feasible and effective alternative to oral anticoagulation in patients with non-valvular atrial fibrillation. However, only few data about in-hospital and peri-procedural data are currently available. This study aims to report ab...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-016-0200-z
更新日期：2016-01-28 00:00:00
abstract：BACKGROUND:The aim of our study was to investigate the reliability of automated oscillometric blood pressure (BP) monitoring in the presence and absence of atrial fibrillation (AF) in hypertensive patients. METHODS:BP was measured and compared in 71 randomly selected patients with AF and arterial hypertension diagnosi...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-017-0521-6
更新日期：2017-03-23 00:00:00
abstract：BACKGROUND:Cardiac fibrosis play a key role in the atrial fibrillation pathogenesis but the underlying potential molecular mechanism is still understood. However, potential mechanisms for miR-21 upregulation and its role in cardiac fibrosis remain unclear. The controls cell proliferation and processes fundamental to di...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-017-0520-7
更新日期：2017-03-23 00:00:00
abstract：BACKGROUND:Certain conditions characterised by blood vessel occlusion or vascular spasm have been found to cluster together in epidemiological studies. However the biological causes for these associations remain controversial. This study used a classical twin design to examine whether these conditions are linked throug...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/1471-2261-4-20
更新日期：2004-11-01 00:00:00
abstract：BACKGROUND:This meta-analysis aimed to compare the effects of prasugrel and ticagrelor on high (HTPR) and low on-treatment platelet reactivity (LTPR) in patients with acute coronary syndrome (ACS). METHODS:Eligible studies were retrieved from PubMed, Embase, and the Cochrane Library. HTPR and LTPR were evaluated on th...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章,meta分析
doi：10.1186/s12872-020-01603-0
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:We examined whether impaired renal function causes thickening of the aortic valve leaflets in hyperlipidemic apoE-knockout (apoE-/-) mice, and whether the putative effect on the aortic valves could be prevented by inhibiting the angiotensin-converting enzyme (ACE) with enalapril. METHODS:Thickening of the a...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/1471-2261-9-10
更新日期：2009-03-03 00:00:00
abstract：BACKGROUND:A permanently indwelling filter in the inferior vena cava (IVC) may induce caval thrombosis, which could develop and evolve from an acute to a chronic phase. The differential diagnosis of acute and chronic thromboses determines the treatment strategy. The role of computed tomography (CT) in diagnosing acute ...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-018-0799-z
更新日期：2018-04-11 00:00:00
abstract：BACKGROUND:Several studies showed Type 2 Diabetes Mellitus (T2DM) to be associated with worse adverse clinical outcomes compared to non-T2DM (NDM) following Percutaneous Coronary Intervention (PCI). In addition, patients with insulin-treated T2DM (ITDM) showed worse clinical outcomes compared to patients with non-insul...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章,meta分析,评审
doi：10.1186/s12872-016-0422-0
更新日期：2016-11-25 00:00:00
