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Does depressed persons with non-cardiovascular morbidity have a higher risk of CVD? A population-based cohort study in Sweden.

Abstract：

BACKGROUND:Depression often co-exists with non-cardiovascular morbid conditions. Whether this comorbidity increases the risk of cardiovascular disease has so far not been studied. Thus, the aim of this study was to determine if non-cardiovascular morbidity modifies the effect of depression on future risk of CVD. METHODS:Data was derived from the PART study (acronym in Swedish for: Psykisk hälsa, Arbete och RelaTioner: Mental Health, Work and Relationships), a longitudinal cohort study on mental health, work and relations, including 10,443 adults (aged 20-64 years). Depression was assessed using the Major Depression Inventory (MDI) and self-reported data on non-cardiovascular morbidity was assessed in 1998-2000. Outcomes of CVD were assessed using the National Patient Register during 2001-2014. RESULTS:Both depression (HR 1.5 (95% CI, 1.1, 2.0)) and non-cardiovascular morbidity (HR 2.0 (95% CI, 1.8, 2.6)) were associated with an increased future risk of CVD. The combined effect of depression and non-cardiovascular comorbidity on future CVD was HR 2.1 (95%, CI 1.3, 3.4) after adjusting for age, gender and socioeconomic position. Rather similar associations were seen after further adjustment for hypertension, diabetes and unhealthy lifestyle factors. CONCLUSION:Persons affected by depression in combination with non-cardiovascular morbidity had a higher risk of CVD compared to those without non-cardiovascular morbidity or depression alone.

journal_name

BMC Cardiovasc Disord

journal_title

BMC cardiovascular disorders

authors

Almas A,Moller J,Iqbal R,Lundin A,Forsell Y

doi

10.1186/s12872-019-1252-7

subject

Has Abstract

pub_date

2019-11-21 00:00:00

pages

260

issue

1

issn

1471-2261

pii

10.1186/s12872-019-1252-7

journal_volume

19

pub_type

杂志文章

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