Laparoscopic based renal denervation in a canine neurogenic hypertension model.

Abstract:

BACKGROUND:Previous renal denervation (RDN) studies showed controversial results in reducing blood pressure. The aim of this study was to provide evidence supporting the effectiveness of laparoscopic-based renal denervation (L-RDN) in treating hypertension. METHODS:Sixteen Beagle dogs were randomly divided into RDN group (n = 12) and sham group (n = 4). Neurogenic hypertension was generated in all dogs via carotid artery route. L-RDN was performed in the RDN group, with sham operation performed as a control. Blood pressure (BP) changes were recorded at 2, 4, 6, and 8 weeks after the procedure. Changes in serum creatinine (sCr), blood urea nitrogen (BUN) and level of norepinephrine (NE) were analyzed. Histological changes of kidney and renal arteries were also evaluated. RESULTS:BP and NE levels were significantly elevated after hypertension induction (p < 0.01). Systolic and diastolic BP of RDN group were decreased by 15.5 mmHg and 7.3 mmHg (p < 0.0001 and p = 0.0021, respectively) at the eighth week after L-RDN. Invasive systolic and diastolic BP of RDN group were significantly decreased by 14.5 mmHg and 15.3 mmHg (p < 0.0001). In contrast, there was no significant decrease in blood pressure in the sham group. In addition, RDN group but not the sham group showed a significant decrease in NE levels (p < 0.001), while no significant changes in sCr and BUN were observed in both groups. Pathological examinations showed no discernible damage, tear, or dissection to the renal arteries in RND group. CONCLUSIONS:L-RDN lowered BP and NE levels in hypertensive dogs without affecting renal artery morphology and kidney function.

journal_name

BMC Cardiovasc Disord

authors

Shao C,Zhou Y,You T,Xue B,Stella PR,Jiang TB,Miao Z,Xu L,Yin,Lan L,Rong G

doi

10.1186/s12872-020-01546-6

subject

Has Abstract

pub_date

2020-06-11 00:00:00

pages

285

issue

1

issn

1471-2261

pii

10.1186/s12872-020-01546-6

journal_volume

20

pub_type

杂志文章