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A combination of serum low albumin and above-average cholesterol level was associated with excess mortality.

Abstract：

BACKGROUND:There is no population-based prospective study concerning the relation between serum albumin and mortality in a non-Western population, and few previous studies included the subgroup analysis stratified by serum cholesterol level. METHODS:A 13.7-year cohort study was conducted on 6,957 males and females aged 30-59 years from 300 randomly selected areas throughout Japan, who participated in the National Survey on Circulatory Disorders in 1980. RESULTS:In the group with median and above of total cholesterol, one standard deviation (SD) increment of serum albumin (2.6 g/L for males and 2.4 g/L for females) was inversely associated with all-cause mortality for both males and females (relative risk RR = 0.68 and 0.81: 95% confidence interval CI = 0.53-0.87 and 0.68-0.98), and with cancer mortality for females (RR = 0.74; 95% Cl = 0.57-0.96);and the lowest category of serum albumin (< or = 43 g/L) showed the highest cardiovascular mortality for males (RR = 5.04; 95% CI = 1.04-24.5) among the three albumin categories. These relationships were not evident in the group with total cholesterol level below median. CONCLUSION:A combination of a low albumin level and above average cholesterol level, even both within the clinical normal range,is associated with excess mortality in the Japanese general population.

journal_name

J Clin Epidemiol

journal_title

Journal of clinical epidemiology

authors

Okamura T,Hayakawa T,Kadowaki T,Kita Y,Okayama A,Elliott P,Ueshima H,NIPPON DATA80 research group.

doi

10.1016/j.jclinepi.2004.02.019

subject

Has Abstract

pub_date

2004-11-01 00:00:00

pages

1188-95

issue

11

eissn

0895-4356

issn

1878-5921

pii

S0895-4356(04)00127-1

journal_volume

57

pub_type

杂志文章

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