Can physical activity mitigate the effects of aging in middle-aged women?

abstract：:The present study was performed to determine whether positron emission tomography (PET) performed after i.v. 11C-palmitate permits detection and characterization of nontransmural myocardial infarction. PET was performed after the i.v. injection of 11C-palmitate in 10 normal subjects, 24 patients with initial nontransm...

journal_title：Circulation

authors： Geltman EM,Biello D,Welch MJ,Ter-Pogossian MM,Roberts R,Sobel BE

更新日期：1982-04-01 00:00:00

abstract：BACKGROUND:Intravascular ultrasound imaging was performed in 27 patients after coronary balloon angioplasty to quantify the lumen and atheroma cross-sectional areas. METHODS AND RESULTS:A 20-MHz ultrasound catheter was inserted through a 1.6-mm plastic introducer sheath across the dilated area to obtain real-time imag...

journal_title：Circulation

authors： Tobis JM,Mallery J,Mahon D,Lehmann K,Zalesky P,Griffith J,Gessert J,Moriuchi M,McRae M,Dwyer ML

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:Because acute exercise increases systemic catecholamines, we sought to determine whether exercise training would alter daily or exercise-related catecholamine release and inactivation. METHODS AND RESULTS:In 24-hour urine collections, catecholamines and metabolites provided indexes of overall oxidative deam...

journal_title：Circulation

authors： Rogers PJ,Tyce GM,Weinshilboum RM,O'Connor DT,Bailey KR,Bove AA

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND:Mesenchymal stem cells (MSCs) are bone marrow stromal cells that are in phase 1 clinical studies of cellular cardiomyoplasty. However, the electrophysiological effects of MSC transplantation have not been studied. Although improvement of ventricular function would represent a positive outcome of MSC transpla...

journal_title：Circulation

authors： Chang MG,Tung L,Sekar RB,Chang CY,Cysyk J,Dong P,Marbán E,Abraham MR

更新日期：2006-04-18 00:00:00

abstract：BACKGROUND:Compared with single-chamber ventricular pacing, dual-chamber pacing can reduce adverse events and, as a result, improve quality of life in patients paced for sick sinus syndrome. It is not clear, however, how these benefits compare with the increased cost of dual-chamber pacemakers. METHODS AND RESULTS:We ...

journal_title：Circulation

authors： Rinfret S,Cohen DJ,Lamas GA,Fleischmann KE,Weinstein MC,Orav J,Schron E,Lee KL,Goldman L

更新日期：2005-01-18 00:00:00

abstract：:Correlates of high-density lipoprotein (HDL) cholesterol levels were studied in 4756 white males and females ages 20-59 years examined during a population survey conducted by 10 North American Lipid Research Clinics. Multivariable analysis was used to assess the relation of social, demographic, physical and behavioral...

journal_title：Circulation

authors： Heiss G,Johnson NJ,Reiland S,Davis CE,Tyroler HA

更新日期：1980-11-01 00:00:00

abstract：:Between 1973 and 1983, 90 patients with tricuspid atresia underwent the Fontan operation at the Mayo Clinic. Operative mortality was 12% overall and decreased to 7% during the second 5 year period. At postoperative follow-up of 65 patients (1 to 10 years, mean 4), 50 (86%) of 58 present survivors were in excellent con...

journal_title：Circulation

authors： Mair DD,Rice MJ,Hagler DJ,Puga FJ,McGoon DC,Danielson GK

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND:Some clinical data suggest that atrial-based pacing prevents paroxysmal atrial fibrillation (AF). This study tested the hypothesis that DDDR pacing compared with VDD pacing prevents AF after atrioventricular (AV) junction ablation. METHODS AND RESULTS:Patients were randomized to DDDR pacing (n=33) or to VDD...

journal_title：Circulation

authors： Gillis AM,Connolly SJ,Lacombe P,Philippon F,Dubuc M,Kerr CR,Yee R,Rose MS,Newman D,Kavanagh KM,Gardner MJ,Kus T,Wyse DG

更新日期：2000-08-15 00:00:00

abstract：BACKGROUND:The roles of Purkinje fibers (PFs) and focal wave fronts, if any, in the maintenance of ventricular fibrillation (VF) are unknown. If PFs are involved in VF maintenance, it should be possible to map wave fronts propagating from PFs into the working ventricular myocardium during VF. If wave fronts ever arise ...

journal_title：Circulation

authors： Tabereaux PB,Walcott GP,Rogers JM,Kim J,Dosdall DJ,Robertson PG,Killingsworth CR,Smith WM,Ideker RE

更新日期：2007-09-04 00:00:00

abstract：:Between 1964 and 1971, 49 patients were discharged from hospital following atrial baffle repair for transposition of the great arteries. Electrocardiograms of 47 of these patients were available for review seven months to eight and a half years (average 31 months) after operation. Of the 46 patients in sinus rhythm pr...

journal_title：Circulation

authors： Clarkson PM,Barratt-Boyles BG,Neutze JM

更新日期：1976-03-01 00:00:00

abstract：BACKGROUND:Reperfusion of ischemic rat hearts in the presence of thrombin or norepinephrine but not endothelin-1 causes the generation of inositol 1,4,5-trisphosphate (Ins 1,4,5P3) and arrhythmias. The present study investigates the effect of endothelin-1 on these responses. METHODS AND RESULTS:Ins 1,4,5P3 generation ...

journal_title：Circulation

authors： Woodcock EA,Reyes N,Jacobsen AN,Du XJ

更新日期：1999-02-16 00:00:00

abstract：BACKGROUND:The aim of this study was to determine whether antianginal medications affect the prognostic value of pharmacological stress echocardiography. METHODS AND RESULTS:From the EPIC-EDIC Data Bank, 7333 patients (5452 men; age; 59+/-10 years) underwent pharmacological stress echocardiography with either high-dos...

journal_title：Circulation

authors： Sicari R,Cortigiani L,Bigi R,Landi P,Raciti M,Picano E,Echo-Persantine International Cooperative (EPIC) Study Group.,Echo-Dobutamine International Cooperative (EDIC) Study Group.

更新日期：2004-05-25 00:00:00

abstract：BACKGROUND:We have reported that there is a limitation of exercise capacity in mice with defects in the expression of endothelial nitric oxide (NO) synthase, which is associated with a greater increase in whole-body oxygen consumption (VO2). We hypothesized that in states in which superoxide anion (O2-) is increased, e...

journal_title：Circulation

authors： Kinugawa S,Wang Z,Kaminski PM,Wolin MS,Edwards JG,Kaley G,Hintze TH

更新日期：2005-03-29 00:00:00

abstract：BACKGROUND:The effect of isoproterenol on increasing the peak amplitude of the L-type calcium current is reduced in myocytes dispersed from the epicardial border zone (EBZ) of the 5-day infarcted canine heart when compared with control cells from noninfarcted hearts. This suggests that specific alterations in the beta-...

journal_title：Circulation

authors： Steinberg SF,Zhang H,Pak E,Pagnotta G,Boyden PA

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND:Current two-dimensional echocardiographic measures of right ventricular volume are limited by the asymmetrical and crescentic shape of the ventricle and by difficulty in obtaining standardized views. Three-dimensional echocardiographic reconstruction, which does not require geometric assumptions or standardi...

journal_title：Circulation

authors： Jiang L,Siu SC,Handschumacher MD,Luis Guererro J,Vazquez de Prada JA,King ME,Picard MH,Weyman AE,Levine RA

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Poststroke angiogenesis contributes to long-term recovery after stroke. Signal transducer and activator of transcription-3 (Stat3) is a key regulator for various inflammatory signals and angiogenesis. It was the aim of this study to determine its function in poststroke outcome. METHODS AND RESULTS:We genera...

journal_title：Circulation

authors： Hoffmann CJ,Harms U,Rex A,Szulzewsky F,Wolf SA,Grittner U,Lättig-Tünnemann G,Sendtner M,Kettenmann H,Dirnagl U,Endres M,Harms C

更新日期：2015-05-19 00:00:00

abstract：BACKGROUND:The purpose of this study was to investigate the prevalence of skeletal muscle atrophy and its relation to exercise intolerance and abnormal muscle metabolism in patients with heart failure (HF). METHODS AND RESULTS:Peak VO2, percent ideal body weight (% IBW), 24-hour urine creatinine (Cr), and anthropometr...

journal_title：Circulation

authors： Mancini DM,Walter G,Reichek N,Lenkinski R,McCully KK,Mullen JL,Wilson JR

更新日期：1992-04-01 00:00:00

abstract：:Two hundred-three patients had -echnetium 99m (stannous) pyrophosphate myocardial scintigrams for the evaluation of chest pain and suspected acute myocardial infarction. In addition to routine imaging at 60--90 minutes after injection of the radio-pharmaceutical, the blood pool was imaged immediately in each patient f...

journal_title：Circulation

authors： Cowley MJ,Mantle JA,Rogers WJ,Russel RO Jr,Rackley CE,Logic JR

更新日期：1977-08-01 00:00:00

abstract：BACKGROUND:The renin-angiotensin system regulates blood pressure through its effects on vascular tone, renal hemodynamics, and renal sodium and fluid balance. METHODS AND RESULTS:Using data from a large population-based sample of 1488 siblings having a mean age of 14.8 years and belonging to the youngest generation of...

journal_title：Circulation

authors： Fornage M,Amos CI,Kardia S,Sing CF,Turner ST,Boerwinkle E

更新日期：1998-05-12 00:00:00

abstract：BACKGROUND:We determined the intraclass correlation coefficients (ICC) of repeated measures of the mean levels and variability of RR and muscle sympathetic nerve activity (MSNA) in 7 normal subjects. We examined whether spontaneous fluctuations in RR and MSNA over repeated measurements were mirrored by changes in spect...

journal_title：Circulation

authors： van de Borne P,Montano N,Zimmerman B,Pagani M,Somers VK

更新日期：1997-12-16 00:00:00

abstract：BACKGROUND:The strategy for treating patients with severe asymptomatic carotid artery stenosis and cardiac disease remains unresolved. Staged or combined carotid endarterectomy in these patients offers the potential benefit of decreased neurological morbidity during and after cardiac surgery; however, in high-risk pati...

journal_title：Circulation

authors： Van der Heyden J,Suttorp MJ,Bal ET,Ernst JM,Ackerstaff RG,Schaap J,Kelder JC,Schepens M,Plokker HW

更新日期：2007-10-30 00:00:00

abstract：BACKGROUND:Proto-oncogenes have been implicated in the pathogenesis of gene-mediated myocardial remodeling. In the human heart, however, it has not been clarified whether these proto-oncogenes are related to contractile impairment and structural alteration of the myocardium. The present study is designed to investigate...

journal_title：Circulation

authors： Taketani S,Sawa Y,Taniguchi K,Mitsuno M,Kawaguchi N,Onishi S,Matsuda H

更新日期：1997-11-04 00:00:00

abstract：BACKGROUND:Tenascin is a large extracellular matrix glycoprotein generally found in adult tissues undergoing active remodeling such as healing wounds and tumors. To determine the potential role of tenascin-C (TN-C) in the pathophysiology of atherosclerosis, we investigated the pattern of expression of TN-C in human cor...

journal_title：Circulation

authors： Wallner K,Li C,Shah PK,Fishbein MC,Forrester JS,Kaul S,Sharifi BG

更新日期：1999-03-16 00:00:00

abstract：BACKGROUND:The metabolic syndrome is associated with increased angiotensin II activity, induction of a proinflammatory and oxidative state, and endothelial dysfunction. We evaluated the ability of irbesartan, an angiotensin receptor blocker, and lipoic acid, an antioxidant, to affect endothelial function and inflammati...

journal_title：Circulation

authors： Sola S,Mir MQ,Cheema FA,Khan-Merchant N,Menon RG,Parthasarathy S,Khan BV

更新日期：2005-01-25 00:00:00

abstract：BACKGROUND:Inhibition of fibrinolysis attributable to elevated concentrations of plasminogen activator inhibitor type 1 (PAI-1) in blood is associated with insulin resistance, hyperinsulinemia, and type 2 diabetes mellitus. Because we have shown that insulin can stimulate PAI-1 synthesis in vivo and because accelerated...

journal_title：Circulation

authors： Sobel BE,Woodcock-Mitchell J,Schneider DJ,Holt RE,Marutsuka K,Gold H

更新日期：1998-06-09 00:00:00

abstract：BACKGROUND:Reperfusion injury is insufficiently addressed in current clinical management of acute limb ischemia. Controlled reperfusion carries an enormous clinical potential and was tested in a new reality-driven rodent model. METHODS AND RESULTS:Acute hind-limb ischemia was induced in Wistar rats and maintained for ...

journal_title：Circulation

authors： Dick F,Li J,Giraud MN,Kalka C,Schmidli J,Tevaearai H

更新日期：2008-11-04 00:00:00

abstract：BACKGROUND:Depressed ventricular performance and neurohormonal activation are key pathophysiological features of congestive heart failure (CHF). Although angiotensin-converting enzyme inhibitors and beta-adrenoceptor blockers exert beneficial effects in CHF, mortality remains unacceptably high, and the development of f...

journal_title：Circulation

authors： Kaye DM,Mansfield D,Aggarwal A,Naughton MT,Esler MD

更新日期：2001-05-15 00:00:00

abstract：BACKGROUND:Cardiac effects of hypertension include increased left ventricular (LV) mass and LV hypertrophy, as well as increased left atrial size, a predictor of stroke and atrial fibrillation. Although literature on reduction of LV mass with antihypertensive therapy is extensive, little information is available on eff...

journal_title：Circulation

authors： Gottdiener JS,Reda DJ,Williams DW,Materson BJ,Cushman W,Anderson RJ

更新日期：1998-07-14 00:00:00

abstract：BACKGROUND:The extent of microvascular obstruction during acute coronary occlusion may determine the eventual magnitude of myocardial damage and thus, patient prognosis after infarction. By contrast-enhanced MRI, regions of profound microvascular obstruction at the infarct core are hypoenhanced and correspond to greate...

journal_title：Circulation

authors： Wu KC,Zerhouni EA,Judd RM,Lugo-Olivieri CH,Barouch LA,Schulman SP,Blumenthal RS,Lima JA

更新日期：1998-03-03 00:00:00

abstract：BACKGROUND:Recent studies suggest that the oxygen-sensing pathway consisting of transcription factor hypoxia-inducible factor and prolyl hydroxylase domain proteins (PHDs) plays a critical role in glucose metabolism. However, the role of adipocyte PHD in the development of obesity has not been clarified. We examined wh...

journal_title：Circulation

authors： Matsuura H,Ichiki T,Inoue E,Nomura M,Miyazaki R,Hashimoto T,Ikeda J,Takayanagi R,Fong GH,Sunagawa K

更新日期：2013-05-28 00:00:00