Abstract:
:Within the framework of the OPTIVIP project, an optic nerve based visual prosthesis is developed in order to restore partial vision to the blind. One of the main challenges is to understand, decode and model the physiological process linking the stimulating parameters to the visual sensations produced in the visual field of a blind volunteer. We propose to use adaptive neural techniques. Two prediction models are investigated. The first one is a grey-box model exploiting the neurophysiological knowledge available up to now. It combines a neurophysiological model with artificial neural networks, such as multi-layer perceptrons and radial basis function networks, in order to predict the features of the visual perceptions. The second model is entirely of the black-box type. We show that both models provide satisfactory prediction tools and achieve similar prediction accuracies. Moreover, we demonstrate that significant improvement (25%) was gained with respect to linear statistical methods, suggesting that the biological process is strongly non-linear.
journal_name
Artif Intell Medjournal_title
Artificial intelligence in medicineauthors
Archambeau C,Delbeke J,Veraart C,Verleysen Mdoi
10.1016/j.artmed.2004.02.004subject
Has Abstractpub_date
2004-11-01 00:00:00pages
183-94issue
3eissn
0933-3657issn
1873-2860pii
S0933365704000442journal_volume
32pub_type
杂志文章abstract:OBJECTIVE:In this paper, we aim to evaluate the use of electronic technologies in out of hours (OoH) task-management for assisting the design of effective support systems in health care; targeting local facilities, wards or specific working groups. In addition, we seek to draw and validate conclusions with relevance to...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2016.09.005
更新日期:2016-10-01 00:00:00
abstract::The purpose of a clinical trial is to evaluate a new treatment procedure. When medical researchers conduct a trial, they recruit participants with appropriate health problems and medical histories. To select participants, they analyze medical records of the available patients, which has traditionally been a manual pro...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2004.01.017
更新日期:2004-07-01 00:00:00
abstract::Cancer is a fatal disease, responsible for one-quarter of all deaths in developed countries. Traditional anticancer therapies such as, chemotherapy and radiation, are highly expensive, susceptible to errors and ineffective techniques. These conventional techniques induce severe side-effects on human cells. Due to peri...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2017.06.008
更新日期:2017-06-01 00:00:00
abstract::Medical diagnosis and therapy planning at modern intensive care units (ICUs) have been refined by the technical improvement of their equipment. However, the bulk of continuous data arising from complex monitoring systems in combination with discontinuously assessed numerical and qualitative data creates a rising infor...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/s0933-3657(96)00355-7
更新日期:1996-11-01 00:00:00
abstract::Deregulated splicing machinery components have shown to be associated with the development of several types of cancer and, therefore, the determination of such alterations can help the development of tumor-specific molecular targets for early prognosis and therapy. Determining such splicing components, however, is not...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2020.101950
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:Traditional Chinese medicine (TCM) is a scientific discipline, which develops the related theories from the long-term clinical practices. The large-scale clinical data are the core empirical knowledge source for TCM research. This paper introduces a clinical data warehouse (CDW) system, which incorporates the...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2009.07.012
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVES:The objective of this study is to devise a modelling strategy for attaining in-silico models replicating human physiology and, in particular, the activity of the autonomic nervous system. METHOD:Discrete Multiphysics (a multiphysics modelling technique) and Reinforcement Learning (a Machine Learning algorit...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2019.06.005
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:Gene Ontology (GO) has become a routine resource for functional analysis of gene lists. Although a number of tools have been provided to identify enriched GO terms in one or two gene lists, two technical challenges remain. First, how to handle multiple hypothesis testing in the analysis given that the tests a...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2007.08.002
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVE:In this paper, we propose a novel algorithm to extract the active intervals of intracardiac electrograms during atrial fibrillation. METHODS:First, we show that the characteristics of the signal waveform at its inflection points are prominent features that are implicitly used by human annotators for distingu...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2018.02.003
更新日期:2018-04-01 00:00:00
abstract::The research at the IIIA has produced over more than a decade two versions of a tool for developing knowledge-based systems: Milord and Milord II. This tool has been mainly used for the development of medical applications. In this paper we summarize the Milord II approximate reasoning approach based on fuzzy sets, and...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/s0933-3657(00)00080-4
更新日期:2001-01-01 00:00:00
abstract::As part of a plan to promote semi-automatic knowledge acquisition for the medical consultant system CADIAG-II/RHEUMA, this study sought to explore and cope with the variability of results that may be anticipated when performing knowledge acquisition with patient data from different patient settings. Patient data were ...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/s0933-3657(02)00025-8
更新日期:2002-07-01 00:00:00
abstract:OBJECTIVES:Brain-computer interfaces (BCIs) are no longer only used by healthy participants under controlled conditions in laboratory environments, but also by patients and end-users, controlling applications in their homes or clinics, without the BCI experts around. But are the technology and the field mature enough f...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2013.08.004
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:The amount of new discoveries (as published in the scientific literature) in the biomedical area is growing at an exponential rate. This growth makes it very difficult to filter the most relevant results, and thus the extraction of the core information becomes very expensive. Therefore, there is a growing int...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2006.08.005
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVE:In this paper, we extend a preliminary proposal and discuss in a deeper and more formal way an approach to evaluate temporal similarity between clinical workflow cases (i.e., executions of clinical processes). More precisely, we focus on (i) the representation of clinical processes by using a temporal concept...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2008.07.013
更新日期:2009-05-01 00:00:00
abstract::In this study different substitution methods for the replacement of missing data values were inspected for the use of these cases in a neural network based decision support system for acute appendicitis. The leucocyte count had the greatest number of missing values and was used in the analyses. Four different methods ...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/s0933-3657(98)00027-x
更新日期:1998-07-01 00:00:00
abstract:OBJECTIVES:The radiology report is the most important source of clinical imaging information. It documents critical information about the patient's health and the radiologist's interpretation of medical findings. It also communicates information to the referring physicians and records that information for future clinic...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章,多中心研究
doi:10.1016/j.artmed.2015.09.007
更新日期:2016-01-01 00:00:00
abstract::Computer-aided detection (CADe) systems play a crucial role in pulmonary nodule detection via chest radiographs (CXRs). A two-stage CADe scheme usually includes nodule candidate detection and false positive reduction. A pure deep learning model, such as faster region convolutional neural network (faster R-CNN), has be...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2020.101881
更新日期:2020-07-01 00:00:00
abstract::Automatic arrhythmia detection based on electrocardiogram (ECG) is of great significance for early prevention and diagnosis of cardiac diseases. Recently, deep learning methods have been applied to arrhythmia detection and obtained great success. Among them, convolutional neural network (CNN) is an effective method fo...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2020.101856
更新日期:2020-06-01 00:00:00
abstract::In this contribution we present an application of a knowledge-based neural network technique in the domain of medical research. We consider the crucial problem of intensive care patients developing a septic shock during their stay at the intensive care unit. Septic shock is of prime importance in intensive care medici...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/s0933-3657(03)00057-5
更新日期:2003-06-01 00:00:00
abstract::Melanoma is the most dangerous skin cancer and early diagnosis is the key factor in its successful treatment. Well-trained dermatologists reach a diagnosis via visual inspection, and reach sensitivity and specificity levels of about 80%. Several computerised diagnostic systems were reported in the literature using dif...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/s0933-3657(02)00087-8
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:Connect-Four, a new sensorimotor rhythm (SMR) based brain-computer interface (BCI) gaming application, was evaluated by four severely motor restricted end-users; two were in the locked-in state and had unreliable eye-movement. METHODS:Following the user-centred approach, usability of the BCI prototype was ev...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2013.08.001
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:A major focus in computational system biology research is defining organizing principles that govern complex biological network formation and evolution. The task is considered a major challenge because network behavior and function prediction requires the identification of functionally and statistically impor...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2007.07.006
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVE:Ontologies are widely used in the biomedical domain. While many tools exist for the edition, alignment or evaluation of ontologies, few solutions have been proposed for ontology programming interface, i.e. for accessing and modifying an ontology within a programming language. Existing query languages (such as...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2017.07.002
更新日期:2017-07-01 00:00:00
abstract::Abnormalities in the organization of brain circuits may underlie many types of epilepsy. This hypothesis can best be evaluated in the case of temporal lobe epilepsy, where evidence of rewiring (synaptic reorganization) can be found in the dentate gyrus. Computer modeling of normal and reorganized dentate gyrus was use...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/s0933-3657(98)00005-0
更新日期:1998-05-01 00:00:00
abstract:OBJECTIVE:Protein homology prediction between protein sequences is one of critical problems in computational biology. Such a complex classification problem is common in medical or biological information processing applications. How to build a model with superior generalization capability from training samples is an ess...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2005.02.003
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVE:Most practically deployed Arden-Syntax-based clinical decision support (CDS) modules process data from individual patients. The specification of Arden Syntax, however, would in principle also support multi-patient CDS. The patient data management system (PDMS) at our local intensive care units does not native...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2015.09.009
更新日期:2018-11-01 00:00:00
abstract::We created an inference engine and query language for expressing temporal patterns in data. The patterns are represented by using temporally-ordered sets of data objects. Patterns are elaborated by reference to new objects inferred from original data, and by interlocking temporal and other relationships among sets of ...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/0933-3657(94)90066-3
更新日期:1994-06-01 00:00:00
abstract::Quality of life of patients with Parkinson's disease degrades significantly with disease progression. This paper presents a step towards personalized management of Parkinson's disease patients, based on discovering groups of similar patients. Similarity is based on patients' medical conditions and changes in the presc...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2018.04.010
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:This work presents a system for a simultaneous non-invasive estimate of the blood glucose level (BGL) and the systolic (SBP) and diastolic (DBP) blood pressure, using a photoplethysmograph (PPG) and machine learning techniques. The method is independent of the person whose values are being measured and does n...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2011.05.001
更新日期:2011-10-01 00:00:00
abstract::In this paper, we propose an approach for managing clinical guidelines. We outline a modular architecture, allowing us to separate two conceptually distinct aspects: the representation (and acquisition) of clinical guidelines and their execution. We propose an expressive formalism, which allows one to deal with the co...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章,评审
doi:10.1016/s0933-3657(01)00087-2
更新日期:2001-11-01 00:00:00