Abstract:
OBJECTIVE:Traditional Chinese medicine (TCM) is a scientific discipline, which develops the related theories from the long-term clinical practices. The large-scale clinical data are the core empirical knowledge source for TCM research. This paper introduces a clinical data warehouse (CDW) system, which incorporates the structured electronic medical record (SEMR) data for medical knowledge discovery and TCM clinical decision support (CDS). MATERIALS AND METHODS:We have developed the clinical reference information model (RIM) and physical data model to manage the various information entities and their relationships in TCM clinical data. An extraction-transformation-loading (ETL) tool is implemented to integrate and normalize the clinical data from different operational data sources. The CDW includes online analytical processing (OLAP) and complex network analysis (CNA) components to explore the various clinical relationships. Furthermore, the data mining and CNA methods are used to discover the valuable clinical knowledge from the data. RESULTS:The CDW has integrated 20,000 TCM inpatient data and 20,000 outpatient data, which contains manifestations (e.g. symptoms, physical examinations and laboratory test results), diagnoses and prescriptions as the main information components. We propose a practical solution to accomplish the large-scale clinical data integration and preprocessing tasks. Meanwhile, we have developed over 400 OLAP reports to enable the multidimensional analysis of clinical data and the case-based CDS. We have successfully conducted several interesting data mining applications. Particularly, we use various classification methods, namely support vector machine, decision tree and Bayesian network, to discover the knowledge of syndrome differentiation. Furthermore, we have applied association rule and CNA to extract the useful acupuncture point and herb combination patterns from the clinical prescriptions. CONCLUSION:A CDW system consisting of TCM clinical RIM, ETL, OLAP and data mining as the core components has been developed to facilitate the tasks of TCM knowledge discovery and CDS. We have conducted several OLAP and data mining tasks to explore the empirical knowledge from the TCM clinical data. The CDW platform would be a promising infrastructure to make full use of the TCM clinical data for scientific hypothesis generation, and promote the development of TCM from individualized empirical knowledge to large-scale evidence-based medicine.
journal_name
Artif Intell Medjournal_title
Artificial intelligence in medicineauthors
Zhou X,Chen S,Liu B,Zhang R,Wang Y,Li P,Guo Y,Zhang H,Gao Z,Yan Xdoi
10.1016/j.artmed.2009.07.012subject
Has Abstractpub_date
2010-02-01 00:00:00pages
139-52issue
2-3eissn
0933-3657issn
1873-2860pii
S0933-3657(09)00105-5journal_volume
48pub_type
杂志文章abstract::Artificial intelligence (AI) will pave the way to a new era in medicine. However, currently available AI systems do not interact with a patient, e.g., for anamnesis, and thus are only used by the physicians for predictions in diagnosis or prognosis. However, these systems are widely used, e.g., in diabetes or cancer p...
journal_title:Artificial intelligence in medicine
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journal_title:Artificial intelligence in medicine
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doi:10.1016/s0933-3657(03)00053-8
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abstract:OBJECTIVES:The existence of proper non-invasive temperature estimators is an essential aspect when thermal therapy applications are envisaged. These estimators must be good predictors to enable temperature estimation at different operational situations, providing better control of the therapeutic instrumentation. In th...
journal_title:Artificial intelligence in medicine
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doi:10.1016/j.artmed.2008.03.008
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journal_title:Artificial intelligence in medicine
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journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2014.12.001
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journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2005.02.007
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journal_title:Artificial intelligence in medicine
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doi:10.1016/j.artmed.2008.07.013
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journal_title:Artificial intelligence in medicine
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doi:10.1016/j.artmed.2006.03.009
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journal_title:Artificial intelligence in medicine
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pub_type: 杂志文章
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journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2019.07.010
更新日期:2019-08-01 00:00:00
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journal_title:Artificial intelligence in medicine
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更新日期:2018-11-01 00:00:00
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journal_title:Artificial intelligence in medicine
pub_type: 杂志文章,多中心研究
doi:10.1016/j.artmed.2015.09.007
更新日期:2016-01-01 00:00:00
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更新日期:2005-07-01 00:00:00
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doi:10.1016/j.artmed.2006.08.005
更新日期:2007-02-01 00:00:00
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