Abstract:
OBJECTIVE:Protein homology prediction between protein sequences is one of critical problems in computational biology. Such a complex classification problem is common in medical or biological information processing applications. How to build a model with superior generalization capability from training samples is an essential issue for mining knowledge to accurately predict/classify unseen new samples and to effectively support human experts to make correct decisions. METHODOLOGY:A new learning model called granular support vector machines (GSVM) is proposed based on our previous work. GSVM systematically and formally combines the principles from statistical learning theory and granular computing theory and thus provides an interesting new mechanism to address complex classification problems. It works by building a sequence of information granules and then building support vector machines (SVM) in some of these information granules on demand. A good granulation method to find suitable granules is crucial for modeling a GSVM with good performance. In this paper, we also propose an association rules-based granulation method. For the granules induced by association rules with high enough confidence and significant support, we leave them as they are because of their high "purity" and significant effect on simplifying the classification task. For every other granule, a SVM is modeled to discriminate the corresponding data. In this way, a complex classification problem is divided into multiple smaller problems so that the learning task is simplified. RESULTS AND CONCLUSIONS:The proposed algorithm, here named GSVM-AR, is compared with SVM by KDDCUP04 protein homology prediction data. The experimental results show that finding the splitting hyperplane is not a trivial task (we should be careful to select the association rules to avoid overfitting) and GSVM-AR does show significant improvement compared to building one single SVM in the whole feature space. Another advantage is that the utility of GSVM-AR is very good because it is easy to be implemented. More importantly and more interestingly, GSVM provides a new mechanism to address complex classification problems.
journal_name
Artif Intell Medjournal_title
Artificial intelligence in medicineauthors
Tang Y,Jin B,Zhang YQdoi
10.1016/j.artmed.2005.02.003subject
Has Abstractpub_date
2005-09-01 00:00:00pages
121-34issue
1-2eissn
0933-3657issn
1873-2860pii
S0933-3657(05)00054-0journal_volume
35pub_type
杂志文章abstract::In case-based studies, controls are retrospectively assigned to patients in order to permit a statistical evaluation of the study results through a comparison of the main outcome measures for the patient and retrieved control groups. Inappropriate selection of the controls by using false retrieval parameters or a fals...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/s0933-3657(02)00084-2
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:After several years of treatment, patients with Parkinson's disease (PD) tend to have, as a side effect of the medication, dyskinesias. Close monitoring may benefit patients by enabling doctors to tailor a personalised medication regimen. Moreover, dyskinesia monitoring can help neurologists make more inform...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2016.01.001
更新日期:2016-02-01 00:00:00
abstract::The purpose of a clinical trial is to evaluate a new treatment procedure. When medical researchers conduct a trial, they recruit participants with appropriate health problems and medical histories. To select participants, they analyze medical records of the available patients, which has traditionally been a manual pro...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2004.01.017
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVES:We propose a new graphical framework for extracting the relevant dietary, social and environmental risk factors that are associated with an increased risk of nasopharyngeal carcinoma (NPC) on a case-control epidemiologic study that consists of 1289 subjects and 150 risk factors. METHODS:This framework build...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2011.09.002
更新日期:2012-01-01 00:00:00
abstract::This work presents a hybrid expert system (HES) intended to minimise some complex problems pervasive to knowledge engineering such as: the knowledge elicitation process, known as the bottleneck of expert systems; the choice of a model for knowledge representation to codify human reasoning; the number of neurons in the...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/s0933-3657(00)00090-7
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:The objective of this work is to investigate a possibility of creating a computer-aided decision support system for an automated analysis of vocal cord images aiming to categorize diseases of vocal cords. METHODOLOGY:The problem is treated as a pattern recognition task. To obtain a concise and informative re...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2004.11.001
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVES:The radiology report is the most important source of clinical imaging information. It documents critical information about the patient's health and the radiologist's interpretation of medical findings. It also communicates information to the referring physicians and records that information for future clinic...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章,多中心研究
doi:10.1016/j.artmed.2015.09.007
更新日期:2016-01-01 00:00:00
abstract:CONTEXT:Temporal information plays a crucial role in medicine, so that in medical informatics there is an increasing awareness that suitable database approaches are needed to store and support it. Specifically, a great amount of clinical data (e.g., therapeutic data) are periodically repeated. Although an explicit trea...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2012.03.002
更新日期:2012-07-01 00:00:00
abstract::Diagnosis of visual function losses in glaucomatous patients depends to a large extent on the analysis of the data collected from corresponding psychophysical tests. One of the main difficulties in obtaining reliable data from patients in these tests is the measurement noise caused by the learning effect, inattention,...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/0933-3657(94)90004-3
更新日期:1994-10-01 00:00:00
abstract:OBJECTIVE:In this paper, we propose a novel algorithm to extract the active intervals of intracardiac electrograms during atrial fibrillation. METHODS:First, we show that the characteristics of the signal waveform at its inflection points are prominent features that are implicitly used by human annotators for distingu...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2018.02.003
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND AND MOTIVATION:DNA microarray technology has made it possible to determine the expression levels of thousands of genes in parallel under multiple experimental conditions. Genome-wide analyses using DNA microarrays make a great contribution to the exploration of the dynamic state of genetic networks, and furt...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2005.02.007
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVE:Gene Ontology (GO) has become a routine resource for functional analysis of gene lists. Although a number of tools have been provided to identify enriched GO terms in one or two gene lists, two technical challenges remain. First, how to handle multiple hypothesis testing in the analysis given that the tests a...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2007.08.002
更新日期:2007-10-01 00:00:00
abstract::In this paper, we propose an approach for managing clinical guidelines. We outline a modular architecture, allowing us to separate two conceptually distinct aspects: the representation (and acquisition) of clinical guidelines and their execution. We propose an expressive formalism, which allows one to deal with the co...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章,评审
doi:10.1016/s0933-3657(01)00087-2
更新日期:2001-11-01 00:00:00
abstract::Deregulated splicing machinery components have shown to be associated with the development of several types of cancer and, therefore, the determination of such alterations can help the development of tumor-specific molecular targets for early prognosis and therapy. Determining such splicing components, however, is not...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2020.101950
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:To assess whether a user-centred prototype clinical decision support system (CDSS) providing patient-specific advice better supports healthcare practitioners in terms of (a) types of usability problems detected and (b) effective and efficient retrieval of childhood cancer survivor's follow-up screening proced...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2013.04.004
更新日期:2013-09-01 00:00:00
abstract::Automatic arrhythmia detection based on electrocardiogram (ECG) is of great significance for early prevention and diagnosis of cardiac diseases. Recently, deep learning methods have been applied to arrhythmia detection and obtained great success. Among them, convolutional neural network (CNN) is an effective method fo...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2020.101856
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Patients who are readmitted to an intensive care unit (ICU) usually have a high risk of mortality and an increased length of stay. ICU readmission risk prediction may help physicians to re-evaluate the patient's physical conditions before patients are discharged and avoid preventable readmissions. ICU readmi...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2018.08.004
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVE:We provide a survey of recent advances in biomedical image analysis and classification from emergent imaging modalities such as terahertz (THz) pulse imaging (TPI) and dynamic contrast-enhanced magnetic resonance images (DCE-MRIs) and identification of their underlining commonalities. METHODS:Both time and f...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2016.01.005
更新日期:2016-02-01 00:00:00
abstract::Standard Back Propagation (BP), Partially Recurrent (PR) and Cascade-Correlation (CC) neural networks were used to predict the side of finger movement on the basis of non-averaged single trial multi-channel EEG data recorded prior to movement. From these EEG data, power values were calculated and used as parameters fo...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/0933-3657(93)90040-a
更新日期:1993-12-01 00:00:00
abstract:OBJECTIVE:To use the detection of clinically relevant inconsistencies to support the reasoning capabilities of intelligent agents acting as physicians and tutors in the realm of clinical medicine. METHODS:We are developing a cognitive architecture, OntoAgent, that supports the creation and deployment of intelligent ag...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2012.04.005
更新日期:2012-07-01 00:00:00
abstract::Artificial intelligence (AI) will pave the way to a new era in medicine. However, currently available AI systems do not interact with a patient, e.g., for anamnesis, and thus are only used by the physicians for predictions in diagnosis or prognosis. However, these systems are widely used, e.g., in diabetes or cancer p...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2019.101706
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:This paper presents a novel rule-based fuzzy classification methodology for survival/mortality prediction in severe burnt patients. Due to the ethical aspects involved in this medical scenario, physicians tend not to accept a computer-based evaluation unless they understand why and how such a recommendation i...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2013.12.006
更新日期:2014-03-01 00:00:00
abstract::This paper describes the INSIDE system, a networked robot system designed to allow the use of mobile robots as active players in the therapy of children with autism spectrum disorders (ASD). While a significant volume of work has explored the impact of robots in ASD therapy, most such work comprises remotely operated ...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2018.12.003
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:The current situation of critical progression in resistance to more effective antibiotics has forced the reuse of old highly toxic antibiotics and, for several reasons, the extension of the indications of combined antibiotic therapy as alternative options to broad spectrum empirical mono-therapy. A key aspec...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2019.101751
更新日期:2020-01-01 00:00:00
abstract::Within the framework of the OPTIVIP project, an optic nerve based visual prosthesis is developed in order to restore partial vision to the blind. One of the main challenges is to understand, decode and model the physiological process linking the stimulating parameters to the visual sensations produced in the visual fi...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2004.02.004
更新日期:2004-11-01 00:00:00
abstract::Knowledge discovery from omics data has become a common goal of current approaches to personalised cancer medicine and understanding cancer genotype and phenotype. However, high-throughput biomedical datasets are characterised by high dimensionality and relatively small sample sizes with small signal-to-noise ratios. ...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2020.101821
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:The aim of this paper is to provide an improved method for solving the so-called dynamic patient admission scheduling (DPAS) problem. This is a complex scheduling problem that involves assigning a set of patients to hospital beds over a given time horizon in such a way that several quality measures reflecting...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2016.10.002
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:We address the task of inducing explanatory models from observations and knowledge about candidate biological processes, using the illustrative problem of modeling photosynthesis regulation. METHODS:We cast both models and background knowledge in terms of processes that interact to account for behavior. We a...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2006.04.003
更新日期:2006-07-01 00:00:00
abstract::If our goal in Artificial Intelligence in Medicine (AIM) is to engineer systems health-care providers will both use and, in the process, improve their performance, we must concentrate on the development of causal theories of knowledge and problem solving. One broad direction in pursuing this goal is understanding the ...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章,评审
doi:10.1016/0933-3657(93)90013-s
更新日期:1993-04-01 00:00:00
abstract:OBJECTIVE:The objective of this paper is to classify 3D medical images by analyzing spatial distributions to model and characterize the arrangement of the regions of interest (ROIs) in 3D space. METHODS AND MATERIAL:Two methods are proposed for facilitating such classification. The first method uses measures of simila...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2004.07.001
更新日期:2005-03-01 00:00:00