Open-label, dose-ranging pilot study of 4 weeks of low-dose therapy with sodium phosphate tablets in chronically constipated adults.

abstract：:Several patients treated with amoxapine (in dosages ranging from 50 to 300 mg/day) had excellent initial responses followed by relapse unresponsive to dose adjustment, suggesting pharmacological tolerance to its antidepressant effect. ...

journal_title：Clinical therapeutics

authors： Zetin M,Aden G,Moldawsky R

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:High incidences of cardiovascular events coincide with a surge in blood pressure (BP) that occurs in the early morning hours at the time of arousal. Thus, control of BP at this time of day, using oral fixed-dose combinations (FDCs) as required, is important in reducing cardiovascular risk in hypertensive pat...

journal_title：Clinical therapeutics

authors： Lacourcière Y,Neutel JM,Schumacher H

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:According to evidence-based guidelines, the combination of inhaled corticosteroids and inhaled long-acting beta(2)-agonists in a single inhaler is recommended for patients with chronic obstructive pulmonary disease (COPD) who are experiencing exacerbations. The relative effectiveness of combination products ...

journal_title：Clinical therapeutics

authors： Blais L,Forget A,Ramachandran S

更新日期：2010-07-01 00:00:00

abstract：:Outcomes research in oncology is a relatively young field, but its potential for expanding our understanding of patients' experiences with cancer gives it increasing relevance to clinical oncology research. We provide a brief overview of the growing prevalence of oncology outcomes research, and we discuss some of the ...

journal_title：Clinical therapeutics

authors： Schulman KA,Seils DM

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVE:The aim of this research letter was to describe the use of N-carbamoyl-L-glutamate as first-line treatment of hyperammonemia in a 4-month-old female patient with propionic acidemia (PA). METHODS:A 4-month-old female patient weighing 3.9 kg presented with decompensation with PA and initial hyperammonemia of 4...

journal_title：Clinical therapeutics

authors： Soyucen E,Demirci E,Aydin A

更新日期：2010-04-01 00:00:00

abstract：PURPOSE:Surgery, radiotherapy, and chemotherapy are the mainstays of cervical cancer treatment. Many patients receive multiple treatment modalities, each with its own long-term effects. Given the high 5-year survival rate for cervical cancer patients, evaluation and improvement of long-term quality of life are essentia...

journal_title：Clinical therapeutics

authors： Pfaendler KS,Wenzel L,Mechanic MB,Penner KR

更新日期：2015-01-01 00:00:00

abstract：:This paper explores how one health care purchasing coalition in Minnesota, the Buyers Health Care Action Group (BHCAG), has taken an active role in restructuring its local health care market. BHCAG started with the belief that the consumer should be the motivating force in health care delivery. Unfortunately, providin...

journal_title：Clinical therapeutics

authors： Robinow A

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:Clarithromycin is a semisynthetic macrolide that exhibits broad-spectrum activity against gram-positive, gram-negative, and atypical respiratory tract and skin/skin structure pathogens, Mycobacterium species, and Helicobacter pylori. It is indicated for the treatment of a wide variety of respiratory and derm...

journal_title：Clinical therapeutics

authors： Guay DR,Gustavson LE,Devcich KJ,Zhang J,Cao G,Olson CA

更新日期：2001-04-01 00:00:00

abstract：:Hydroxychloroquine (HCQ), an antimalarial agent used to treat patients with autoimmune diseases, has been shown to suppress human immunodeficiency virus type 1 (HIV-1) replication in T cells and monocytes in vitro by inhibiting posttranscriptional modification of the virus. An initial randomized, placebo-controlled cl...

journal_title：Clinical therapeutics

authors： Sperber K,Chiang G,Chen H,Ross W,Chusid E,Gonchar M,Chow R,Liriano O

更新日期：1997-09-01 00:00:00

abstract：PURPOSE:The goal of this study was to review recent clinical studies of azilsartan medoxomil (AZL-M) and chlorthalidone (CLD), a combined angiotensin receptor blocker and thiazide-like diuretic, and its role in recently published guidelines. This review explores the role of AZL-M/CLD in treating patients with hypertens...

journal_title：Clinical therapeutics

authors： Kwon A,Kim GH

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:During amyotrophic lateral sclerosis progression, up to 85% of patients develop dysphagia. Riluzole oral suspension 50 mg/10 mL is bioequivalent to riluzole 50-mg film-coated tablets administered orally under fasting conditions. Here, we compare the bioavailability of a single 50-mg dose of riluzole oral suspen...

journal_title：Clinical therapeutics

authors： Brooks BR,Bettica P,Cazzaniga S

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:The formulary inclusion of proton pump inhibitors (PPIs) in the government hospital health services in Qatar is not comparative or restricted. Requests to include a PPI in the formulary are typically accepted if evidence of efficacy and tolerability is presented. There are no literature reports of a PPI scoring...

journal_title：Clinical therapeutics

authors： Al-Badriyeh D,Alabbadi I,Fahey M,Al-Khal A,Zaidan M

更新日期：2016-05-01 00:00:00

abstract：PURPOSE:This study aims to investigate glycosylated hemoglobin (HbA1c), between-laboratory imprecision (%CV), and pass rates from 2012 to 2015 in Nanjing to provide evidence for improving the HbA1c measurement. METHODS:This was a retrospective, descriptive analysis of HbA1c levels obtained from participating hospitals...

journal_title：Clinical therapeutics

authors： Zhang K,Wang Y,Wei H,Xu Z

更新日期：2017-01-01 00:00:00

abstract：:The effects of 4 weeks of treatment with doxazosin or enalapril on diastolic blood pressure (DBP) and plasma lipid levels were studied in 160 patients 18 to 50 years old with mild-to-moderate hypertension. Comparing baseline measurements with measurements taken after 4 weeks, DBP was significantly reduced by 6.8 +/- 7...

journal_title：Clinical therapeutics

authors： Tan KW,Frise SA

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND:Patients and physicians consider rapid onset of pain relief and pain freedom among the most important attributes of migraine therapy. OBJECTIVE:This study compared the effectiveness of rizatriptan 10 mg and usual-care oral migraine medications in everyday clinical practice settings. METHODS:This was a mult...

journal_title：Clinical therapeutics

authors： Bell CF,Foley KA,Barlas S,Solomon G,Hu XH

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Heart failure places a burden on patients and health care systems worldwide. Although the advent of angiotensin-converting enzyme (ACE) inhibitors markedly improved management of this chronic disorder, treatment is still not optimal, and morbidity and mortality remain high. OBJECTIVE:This review summarizes ...

journal_title：Clinical therapeutics

authors： Dickstein K

更新日期：2001-09-01 00:00:00

abstract：PURPOSE:The goal of this study was to assess and compare the potential clinical and economic value of emerging bone-forming agents using the only currently available agent, teriparatide, as a reference case in patients at high, near-term (imminent, 1- to 2-year) risk of osteoporotic fractures, extending to a lifetime h...

journal_title：Clinical therapeutics

authors： O'Hanlon CE,Parthan A,Kruse M,Cartier S,Stollenwerk B,Jiang Y,Caloyeras JP,Crittenden DB,Barron R

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Many active pharmaceutical ingredients taste bitter and thus are aversive to children as well as many adults. Encapsulation of the medicine in pill or tablet form, an effective method for adults to avoid the unpleasant taste, is problematic for children. Many children cannot or will not swallow solid dose fo...

journal_title：Clinical therapeutics

authors： Mennella JA,Spector AC,Reed DR,Coldwell SE

更新日期：2013-08-01 00:00:00

abstract：PURPOSE:The genetic polymorphism was one of the major considerations for adjusting doses of warfarin in Thai individuals. As a result, new oral anticoagulants (NOACs) were introduced to achieve therapeutic goals in stroke prevention in atrial fibrillation (SPAF) patients. However, a cost-utility analysis in a populatio...

journal_title：Clinical therapeutics

authors： Jarungsuccess S,Taerakun S

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:In vitro studies have demonstrated that ticagrelor, an oral antiplatelet agent, is a substrate, activator, and inhibitor of cytochrome P450 (CYP) 3A. Thus, potential CYP3A-mediated drug-drug interactions may occur. OBJECTIVES:The goal of this article was to report study results on the effect of ticagrelor o...

journal_title：Clinical therapeutics

authors： Teng R,Butler K

更新日期：2013-07-01 00:00:00

abstract：PURPOSE:Chest pain is a common emergency department (ED) presentation that is often unexplained. Recent evidence suggests that disease of the microvessels (arterioles) as opposed to the coronary artery (conduit artery) could explain one third of these cases, particularly in women. Brachial artery reactivity (BAR) is a ...

journal_title：Clinical therapeutics

authors： Safdar B,Ali A,D'Onofrio G,Katz SD

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Drug treatment can defer surgical intervention in benign prostatic hyperplasia (BPH), a common disorder in elderly men, and is widely practiced. Various herbal formulations have been used for the treatment of BPH, but few have been compared with established modern medicines in head-to-head clinical trials. ...

journal_title：Clinical therapeutics

authors： Sengupta G,Hazra A,Kundu A,Ghosh A

更新日期：2011-12-01 00:00:00

abstract：:The effects of long-term treatment with nipradilol, a nitroester-containing beta-blocker, on casual and 24-hour blood pressures were studied in 70 patients with mild-to-moderate essential hypertension. Antihypertensive effects of nipradilol on casual blood pressure were observed in 68% of patients. Nipradilol reduced ...

journal_title：Clinical therapeutics

authors： Haneda T,Ogawa Y,Akaishi T,Takeda H,Tanazawa S,Inoue H,Ohki Y,Kato J,Morimoto H,Kanaya K

更新日期：1995-07-01 00:00:00

abstract：:A benzothiazepine derivative, CRD-401, was administered orally in a dosage of 60 to 120 mg/day to 14 patients with various renal diseases. The systolic pressure was lowered slightly in some cases after administration of CRD-401. Urine volume and urinary excretion of electrolytes were increased by the drug in most pati...

journal_title：Clinical therapeutics

authors： Funyu T,Nigawara K,Ohno K,Hamada W,Yagihashi Y

更新日期：1981-01-01 00:00:00

abstract：:A parallel-group, randomized, double-blind, forced-titration, multicenter study was done to compare the efficacy and safety of once-daily nifedipine coat-core (NIF CC) and once-daily nifedipine gastrointestinal therapeutic system (NIF GITS) dosed in the fasting state in patients with mild-to-moderate essential hyperte...

journal_title：Clinical therapeutics

authors： Glasser SP,Ripa SR,Allenby KS,Schwartz LA,Commins BM,Jungerwirth S

更新日期：1995-03-01 00:00:00

abstract：OBJECTIVES:This study was conducted to estimate the prevalence of antipsychotic polypharmacy among fee-for service state Medicaid beneficiaries initiating antipsychotic drug therapy and to investigate psychiatric and demographic predictors of such polypharmacy. METHODS:This was a retrospective cohort study employing M...

journal_title：Clinical therapeutics

authors： Morrato EH,Dodd S,Oderda G,Haxby DG,Allen R,Valuck RJ

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Panitumumab, formerly known as ABX-EGF, was the first recombinant human immunoglobulin G2 monoclonal antibody approved by the US Food and Drug Administration for the treatment of patients with epidermal growth factor receptor-expressing metastatic colorectal cancer (mCRC) refractory to fluoropyrimidine-, oxa...

journal_title：Clinical therapeutics

authors： Wu M,Rivkin A,Pham T

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:LX4211 is a first-in-class dual inhibitor of sodium-dependent glucose cotransporters 1 and 2 (SGLT1 and SGLT2). SGLT1 is the primary transporter for glucose absorption from the gastrointestinal tract, and SGLT2 is the primary transporter for glucose reabsorption in the kidney. SGLT1 inhibition reduces postpr...

journal_title：Clinical therapeutics

authors： Zambrowicz B,Ogbaa I,Frazier K,Banks P,Turnage A,Freiman J,Boehm KA,Ruff D,Powell D,Sands A

更新日期：2013-08-01 00:00:00

abstract：PURPOSE:New therapies, including daratumumab plus lenalidomide plus dexamethasone (DRd) and daratumumab plus bortezomib plus dexamethasone (DVd), have recently been approved in the United States for patients with multiple myeloma (MM) who have received at least 1 prior line of therapy. However, few treatments have been...

journal_title：Clinical therapeutics

authors： Maiese EM,Ainsworth C,Le Moine JG,Ahdesmäki O,Bell J,Hawe E

更新日期：2018-03-01 00:00:00

abstract：:Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) of the propionic acid family with demonstrated efficacy in the treatment of rheumatoid arthritis and osteoarthritis; a distinguished safety profile; and good tolerability. This report describes a new extended-release formulation that maintains therapeutic pla...

journal_title：Clinical therapeutics

authors： Schumacher HR Jr

更新日期：1994-03-01 00:00:00