Cholinergic deficits in aged rat brain are corrected with nicergoline.

Abstract:

:Choline acetyltransferase (CAT) and muscarinic cholinergic receptor (MCR) activities are markedly reduced in aged as compared with young-adult rat brain. Nicergoline was found to correct these reduced activities in most regions of the brain, especially in the cerebral cortex and hippocampus. Chronic administration of nicergoline had no effect on CAT activity or MCR binding in young-adult rat brain. Nicergoline thus appears to have a specific therapeutic effect on cholinergic functions in aged rat brain, where it acts both pre-synaptically and post-synaptically.

journal_name

Arch Gerontol Geriatr

authors

Ogawa N,Asanuma M,Hirata H,Kondo Y,Kawada Y,Mori A

doi

10.1016/0167-4943(93)90001-x

subject

Has Abstract

pub_date

1993-03-01 00:00:00

pages

103-10

issue

2

eissn

0167-4943

issn

1872-6976

pii

0167-4943(93)90001-X

journal_volume

16

pub_type

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