Abstract:
:Choline acetyltransferase (CAT) and muscarinic cholinergic receptor (MCR) activities are markedly reduced in aged as compared with young-adult rat brain. Nicergoline was found to correct these reduced activities in most regions of the brain, especially in the cerebral cortex and hippocampus. Chronic administration of nicergoline had no effect on CAT activity or MCR binding in young-adult rat brain. Nicergoline thus appears to have a specific therapeutic effect on cholinergic functions in aged rat brain, where it acts both pre-synaptically and post-synaptically.
journal_name
Arch Gerontol Geriatrjournal_title
Archives of gerontology and geriatricsauthors
Ogawa N,Asanuma M,Hirata H,Kondo Y,Kawada Y,Mori Adoi
10.1016/0167-4943(93)90001-xsubject
Has Abstractpub_date
1993-03-01 00:00:00pages
103-10issue
2eissn
0167-4943issn
1872-6976pii
0167-4943(93)90001-Xjournal_volume
16pub_type
杂志文章abstract:INTRODUCTION:Sarcopenia is a geriatric syndrome related to loss of muscle mass and function, leading to disability, frailty and higher mortality. According to European Working Group on Sarcopenia in Older People (EWGSOP) the diagnosis of sarcopenia requires the assessment of muscle mass, muscle force and function, that...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2019.03.021
更新日期:2019-01-01 00:00:00
abstract::Insomnia is a significant problem that may jeopardize elderly residents' quality of life in long-term care settings. However, there are only a few studies dealing with sleeping disturbances among nursing home residents. The goal of this study was to determine the prevalence of insomnia and its associated factors in nu...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2005.06.008
更新日期:2006-01-01 00:00:00
abstract::In studies carried out on 401 individuals from different Spanish regions, blood lipoprotein levels do not show a clear relationship to amounts of animal fat intake because diet habits change in old age. But in these persons there was a significant and positive correlation between actual LDL levels and animal fat intak...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/0167-4943(89)90030-7
更新日期:1989-09-01 00:00:00
abstract::Preventable hospital readmissions have been recognized as indicators of hospital quality, a source of increased healthcare expenditures, and a burden for patients, families, and caregivers. Despite growth of initiatives targeting risk factors associated with potentially avoidable hospital readmissions, the impact of d...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2014.02.010
更新日期:2014-07-01 00:00:00
abstract::Due to the difficulties in recruiting elderly people for psychological studies, a wide range of recruitment methods has been used. The underlying assumption that the recruitment method does not seriously affect the results has to be tested. Results in different worry measures are compared between three samples which w...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.archger.2007.09.009
更新日期:2009-01-01 00:00:00
abstract::Experiments have been performed using oxidized (ID-O) and reduced (ID-H) idebenone in various spin trapping systems. The following results were obtained. (1) ID-O does not have any detectable scavenger effect on the OH* free radicals when they are generated by means of Fenton reaction and trapped using DMPO, PBN or 4-...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/0167-4943(90)90066-f
更新日期:1990-11-01 00:00:00
abstract::This study explored the association between vitamin D insufficiency and frailty syndrome defined by the Fried Frailty Index (FFI) and the Edmonton Frail Scale (EFS) in a northern Taiwan community. Data of 215 subjects participating in an integrated interventional trial involving community-dwelling older adults with a ...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/S0167-4943(10)70006-6
更新日期:2010-02-01 00:00:00
abstract::An augmented home help service was set up in the Rhondda Valley in South Wales in order to facilitate discharge from hospital of elderly subjects who were kept in hospital because of mainly social problems. Patients were allocated to the new service or the pre-existing services according to their date of birth. The ex...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/0167-4943(88)90023-4
更新日期:1988-03-01 00:00:00
abstract:INTRODUCTION:Sarcopenia is a geriatric syndrome characterized by loss of muscle mass and strength. The prevalence in people between 60-70 years is about 5-13% and in adults over 80 years, between 11-50% in the USA. Sarcopenia increases the risk of mortality and nosocomial infections. Community-acquired pneumonia is the...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2019.01.008
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:With the aging phenomenon, there is growing interest in developing effective strategies to counteract dynapenia, the age-related loss of muscle strength. The positive effect of progressive resistance training on muscle strength is well known, however, the effect of nutritional supplementation or its synergis...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.archger.2020.104098
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Hip fractures of older adults are a major public health issue. METHODS:We determined the current trend in the number and incidence (per 100,000 persons) of hip fracture among older adults in Finland by taking into account all persons 50 years of age or older who were admitted to hospitals for primary treatm...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2018.04.008
更新日期:2018-01-01 00:00:00
abstract::The aim of this study was to determine gender discrimination and risk factors in the elderly population and to assess the impact of that discrimination on elderly health. One hundred and sixty-eight elderly individuals who were selected from the records by simple randomized sampling were enrolled in the study. Data we...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2007.01.060
更新日期:2007-11-01 00:00:00
abstract::Brain to plasma concentration ratios of i.v. administered human serum albumin (HSA) in the olfactory bulb, frontal cortex and cerebellum were evaluated in DDD mice of different ages. We measured the brain uptake of serum albumin excluding intravascular content by using a double isotope technique and examined the time ...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/0167-4943(91)90062-u
更新日期:1991-09-01 00:00:00
abstract::The objective of this study was to evaluate the effects of growth and aging on the antioxidant capacities of rat serum and brain, by using two different reactive oxygen species (ROS) generators and two different methods of expressing the results. The antioxidant capacity was determined by using the oxygen radical abso...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/0167-4943(95)00674-5
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Elderly in Egypt is approximately 7.2% of the population. The main physical health problems affecting old age is Non-communicable diseases (NCDs). Depression is the commonest geriatric psychiatric disorder related to various life events. Malnutrition is associated with poor health, and cognitive impairment. ...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2016.06.001
更新日期:2016-09-01 00:00:00
abstract::The demands of long-term care facilities (LTCFs) residents are complex which usually require a range of professionals and caregivers to provide treatment and care. To reduce this fragmentation of care, integrated care models are developed in modern health care system, and a gradual change from traditional LTCF care to...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.archger.2009.05.004
更新日期:2010-05-01 00:00:00
abstract::The authors carried out the psychiatric, neurological and physical examination of persons requesting periodical (every 2 yr) preventive clinical gerontological examinations as well as the examination of their self-evaluation by means of the Dembo-Rubinstein test. The results of the examination showed that the persons ...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/0167-4943(82)90011-5
更新日期:1982-09-01 00:00:00
abstract::Previous studies have demonstrated that sleep-related problems are common in the aging process. Such problems are greater in nursing home residents than other elderly people. This study had the following objectives: (1) establish the clinical profile of nursing home residents according to their quality of sleep and in...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2012.11.011
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Living alone may be associated with greater risk for social isolation and loneliness. Living alone, social isolation, loneliness, and limited engagement in social activity have all been associated with poorer cognitive function in later life. Hence, if individuals who live alone are also at greater risk of i...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2018.12.014
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:Chronic obstructive pulmonary disease (COPD) is often associated with malnutrition, which is in turn associated with poor outcomes. Accordingly, in COPD patients adequate nutrition might improve several clinical and functional outcomes. Nevertheless, information about nutrient intake of older populations with C...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2016.01.006
更新日期:2016-05-01 00:00:00
abstract::Age-related physiologic changes together with high prevalence of chronic illness and the use of multiple medications predispose older adults to syncope. The causes of many of these patients' syncope are unexplained and most remained symptomatic. A thoughtful diagnostic strategy is essential to pinpoint the cause in ea...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/s0167-4943(02)00003-1
更新日期:2002-09-01 00:00:00
abstract::It is important to evaluate body composition changes in subjects with an existing multi-system reduction in capacity, as a small decrease in fat-free mass (FFM) can cause serious impairments. The aim of the study was to describe body composition in old people living in institutions. Body composition data were collecte...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2008.05.012
更新日期:2009-07-01 00:00:00
abstract::We studied whether increased blood homocysteine is a predictor for incident depression in a population-based cohort aged >or=65. A total of 240 men and 217 women were identified at baseline and were assessed 4 years later for depression (Geriatric Depression Scale, GDS >or=10 or use of antidepressants). Risk of incide...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2009.06.009
更新日期:2010-07-01 00:00:00
abstract::The effect of food restriction on the survival characteristics, membrane microviscosity and proliferative response in lymphocytes of female Wistar undernourished rats has been evaluated. Diet restriction was applied starting from the age of 3.5 months by feeding the animals on an every-other-day schedule (EOD). Diet r...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/0167-4943(90)90001-m
更新日期:1990-09-01 00:00:00
abstract:BACKGROUND:There is a growing interest in finding psychosocial predictors related to cognitive function. In our previous research, we conducted a cross-sectional study on memory age identity (MAI) and found that MAI might be associated with objective cognitive performance in non-cognitively impaired elderly. A longitud...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2017.10.007
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:A considerable proportion of individuals in late life experience dual sensory impairment (DSI), which can be defined as the combined presence of hearing and visual problems. However, there is little knowledge regarding the psychosocial correlates of DSI. Consequently, our objective of this study was to ident...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2020.104234
更新日期:2020-08-18 00:00:00
abstract::Our aim was to compare the prevalence of sarcopenia in men and women with hip fracture. We studied 591 of 630 hip fracture inpatients consecutively admitted to our Rehabilitation ward. All the patients underwent a Dual-Energy X-Ray Absorptiometry (DXA) scan 18.4 ± 8.7 (mean ± SD) days after hip fracture occurrence. Sa...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2012.05.002
更新日期:2012-09-01 00:00:00
abstract::Falls among the elderly is a major public health concern. There has been recent extensive research on the effects of Tai Chi in fall prevention among the elderly. As such, we undertook a systematic review to look for evidence on the effect of this intervention. There were seven randomized controlled trials, which met ...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章,评审
doi:10.1016/j.archger.2008.02.018
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:Falls in older adults, notably those with Alzheimer's dementia (AD), are prevalent. Vision and balance impairments are prominent falls risk factors in older adults. However, recent literature in the cognitively impaired suggests that executive function (EF) is important for falls risk assessments. The study ...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/j.archger.2020.104078
更新日期:2020-01-01 00:00:00
abstract::A group of 40 Calabrian centenarians (12 males, 28 females) was studied from June 1 to December 31, 1993. Their age was ranging from 100 to 107 years (mean age: 102.3 +/- 1.8 years). Clinical evaluation was performed by recording anamnestic data, an objective examination, and by assessing cognitive performance, emotio...
journal_title:Archives of gerontology and geriatrics
pub_type: 杂志文章
doi:10.1016/0167-4943(96)86965-2
更新日期:1996-01-01 00:00:00