Isothiocyanates as novel cytotoxic and cytostatic agents: molecular pathway on human transformed and non-transformed cells.

Abstract:

:Cancer chemoprevention is a new approach in the management of cancer. Traditional cytotoxic chemotherapeutic approaches cannot cure most advanced solid malignancies. Chemoprevention can be defined as the use of non-cytotoxic drugs and natural agents to block the progression to invasive cancer. Recently, isothiocyanates, natural products found in the diet of humans, has been shown to function as cancer chemopreventive agents. They are strong inhibitors of phase I enzymes and inducers of phase II enzymes. They can also induce apoptosis and modulate cell-cycle progression of highly proliferating cancer cells. This commentary will review the mechanism of apoptosis and growth inhibition mediated by different isothiocyanates. Particular attention will be given to the effects of the new isothiocyanate 4-(methylthio)butylisothiocyanate (MTBITC). Since selective targeting and low toxicity for normal host tissues are fundamental requisites for proposed chemopreventive agents, we will also review the effects of different isothiocyanates on non-transformed human cells.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Fimognari C,Nüsse M,Berti F,Iori R,Cantelli-Forti G,Hrelia P

doi

10.1016/j.bcp.2004.03.044

subject

Has Abstract

pub_date

2004-09-15 00:00:00

pages

1133-8

issue

6

eissn

0006-2952

issn

1873-2968

pii

S0006295204003703

journal_volume

68

pub_type

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