Isothiocyanates as novel cytotoxic and cytostatic agents: molecular pathway on human transformed and non-transformed cells.


:Cancer chemoprevention is a new approach in the management of cancer. Traditional cytotoxic chemotherapeutic approaches cannot cure most advanced solid malignancies. Chemoprevention can be defined as the use of non-cytotoxic drugs and natural agents to block the progression to invasive cancer. Recently, isothiocyanates, natural products found in the diet of humans, has been shown to function as cancer chemopreventive agents. They are strong inhibitors of phase I enzymes and inducers of phase II enzymes. They can also induce apoptosis and modulate cell-cycle progression of highly proliferating cancer cells. This commentary will review the mechanism of apoptosis and growth inhibition mediated by different isothiocyanates. Particular attention will be given to the effects of the new isothiocyanate 4-(methylthio)butylisothiocyanate (MTBITC). Since selective targeting and low toxicity for normal host tissues are fundamental requisites for proposed chemopreventive agents, we will also review the effects of different isothiocyanates on non-transformed human cells.


Biochem Pharmacol


Biochemical pharmacology


Fimognari C,Nüsse M,Berti F,Iori R,Cantelli-Forti G,Hrelia P




Has Abstract


2004-09-15 00:00:00














  • Protective effect of erythropoietin on the oxidative damage of erythrocyte membrane by hydroxyl radical.

    abstract::Treatment of red blood cells with the copper (II) ascorbate system causes increased lipid peroxidation, increased membrane microviscosity, and phospholipid translocation with a concurrent decrease in cytosolic catalase and glutathione peroxidase activities. All these changes are prevented if the cells are treated with...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Chattopadhyay A,Choudhury TD,Bandyopadhyay D,Datta AG

    更新日期:2000-02-15 00:00:00

  • Activation mechanism of the heterodimeric GABA(B) receptor.

    abstract::The GABA(B) receptor was the first heteromeric G-protein coupled receptor (GPCR) identified. Indeed, both GABA(B1) and GABA(B2) subunits appear necessary to get a functional GABA(B) receptor. Soon after the cloning of both subunits, it was demonstrated that GABA(B2) was required for GABA(B1) to reach the cell surface....

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Pin JP,Kniazeff J,Binet V,Liu J,Maurel D,Galvez T,Duthey B,Havlickova M,Blahos J,Prézeau L,Rondard P

    更新日期:2004-10-15 00:00:00

  • Molecular mechanism of L-DNase II activation and function as a molecular switch in apoptosis.

    abstract::The discovery of caspase activation counts as one of the most important finds in the biochemistry of apoptosis. However, targeted disruption of caspases does not impair every type of apoptosis. Other proteases can replace caspases and several so called "caspase independent" pathways are now described. Here we review o...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章,评审


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    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


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    更新日期:2012-09-01 00:00:00

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    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


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    更新日期:1999-06-01 00:00:00

  • Modification of the inhibitory effects of CCl4 on phospholipid and protein biosynthesis by prostacyclin.

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    pub_type: 杂志文章


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    journal_title:Biochemical pharmacology

    pub_type: 杂志文章,评审


    authors: Chow CY,Absalom N,Biggs K,King GF,Ma L

    更新日期:2020-11-01 00:00:00

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    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


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    pub_type: 杂志文章


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    更新日期:1982-10-01 00:00:00

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    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


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    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


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    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


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    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


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    更新日期:2019-01-01 00:00:00

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    pub_type: 杂志文章


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    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


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    更新日期:1986-02-15 00:00:00

  • Protective effect of boldine on dopamine-induced membrane permeability transition in brain mitochondria and viability loss in PC12 cells.

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    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Youn YC,Kwon OS,Han ES,Song JH,Shin YK,Lee CS

    更新日期:2002-02-01 00:00:00

  • Imidazole antimycotics: inhibitors of steroid aromatase.

    abstract::Miconazole and clotrimazole, members of a class of imidazole agents which have broad spectrum antimycotic activity, were shown to be potent inhibitors of steroid aromatase activity of human placental microsomes. The I50 values for the inhibition of aromatase activity by miconazole, clotrimazole, ketoconazole, and amin...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Mason JI,Murry BA,Olcott M,Sheets JJ

    更新日期:1985-04-01 00:00:00

  • Analysis of protein synthesis in rat salivary glands after chronic treatment with beta-receptor agonists and phosphodiesterase inhibitors.

    abstract::Chronic administration of the beta-adrenergic receptor agonist isoproterenol (5 mg/200 g animal for 10 days) resulted in rat parotid and submandibular gland hypertrophy, and it induced synthesis of a series of proline-rich proteins (PRPs) and glycoproteins. Treated parotid glands additionally exhibit an increase in ac...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Wells DJ,Humphreys-Beher MG

    更新日期:1985-12-15 00:00:00

  • Attenuation of 6-hydroxydopamine (6-OHDA)-induced nuclear factor-kappaB (NF-kappaB) activation and cell death by tea extracts in neuronal cultures.

    abstract::Antioxidant and anti-inflammatory therapy approaches have been in the focus of attention in the treatment of neurodegenerative Parkinson's and Alzheimer's diseases where oxidative stress has been implicated. Tea extracts have been previously reported to possess radical scavenger, iron chelating and anti-inflammatory p...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Levites Y,Youdim MB,Maor G,Mandel S

    更新日期:2002-01-01 00:00:00

  • Inhibition of hyaluronan export from human fibroblasts by inhibitors of multidrug resistance transporters.

    abstract::In a previous report we described the export of hyaluronan from Streptococcus pyogenes by an ABC transporter. Extending these findings a sequence homology search against human proteins revealed a strong homology to the multidrug resistance transporter ABC-B (MDR-1) and ABC-C (MRP 5). Using several inhibitors directed ...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Prehm P,Schumacher U

    更新日期:2004-10-01 00:00:00

  • Dinner at Orazio's--David Triggle the model of a mentor.

    abstract::What does it mean to be a mentor in science? Definitions of mentorship are freely spouted in publications and include concepts such as academic support, professional development, role modeling, interaction, impartment of knowledge, evaluation of work, demonstration of methodology, etc. Perhaps most of us would agree w...

    journal_title:Biochemical pharmacology

    pub_type: 传,历史文章,杂志文章,评审


    authors: Smith SL

    更新日期:2015-11-15 00:00:00

  • Regulation of nuclear factor-kappa B, activator protein-1, and glutathione levels by tumor necrosis factor-alpha and dexamethasone in alveolar epithelial cells.

    abstract::The development of an oxidant/antioxidant imbalance in lung inflammation may activate redox-sensitive transcription factors such as nuclear factor-kappa B (NF-kappa B) and activator protein-1 (AP-1), which regulate the genes for proinflammatory mediators and protective antioxidant genes. GSH, a ubiquitous tripeptide t...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章,评审


    authors: Rahman I

    更新日期:2000-10-15 00:00:00

  • Thioredoxin reductase 1 knockdown enhances selenazolidine cytotoxicity in human lung cancer cells via mitochondrial dysfunction.

    abstract::Thioredoxin reductase (TR1) is a selenoprotein that is involved in cellular redox status control and deoxyribonucleotide biosynthesis. Many cancers, including lung, overexpress TR1, making it a potential cancer therapy target. Previous work has shown that TR1 knockdown enhances the sensitivity of cancer cells to antic...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Poerschke RL,Moos PJ

    更新日期:2011-01-15 00:00:00

  • In vivo and in vitro studies on the effects of some phenothiazines and sulpiride on kynurenine metabolism.

    abstract::The effect of 5 consecutive daily i.p. doses of CPZ (5 mg/kg), PZ (10 mg/kg) and PMZ (10 mg/kg) on the activity of kynurenine hydrolase and kynurenine aminotransferase in mouse liver was studied. All three phenothiazines effected an increase in the activity of kynurenine hydrolase per unit weight of liver with CPZ sho...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Mostafa MH,El-Sewedy SM,El-Bassiouni EA,Abdel-Tawab GA

    更新日期:1982-07-01 00:00:00

  • 2'-Hydroxyflavanone: A promising molecule for kidney cancer prevention.

    abstract::Kidney cancer, also known as renal cell carcinoma (RCC), is one of the top 10 diagnosed cancers in the USA, and the incidence is rising. Despite major improvements in drug therapy strategies, RCC remains a deadly malignancy if not found and removed in its early stages. RCC is so highly drug-resistant that no effective...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章,评审


    authors: Singhal SS,Singhal J,Figarola JL,Riggs A,Horne D,Awasthi S

    更新日期:2015-08-01 00:00:00

  • Effects of the enantiomers of lansoprazole (AG-1749) on (H+ + K+)-ATPase activity in canine gastric microsomes and acid formation in isolated canine parietal cells.

    abstract::The effects of the enantiomers of 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]-sulfinyl ]- 1H-benzimidazole (lansoprazole, AG-1749) on acid formation in isolated canine parietal cells and (H+ + K+)-ATPase activity in canine gastric microsomes were investigated. Both the (+)-and the (-)-enantiomer of lanso...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Nagaya H,Inatomi N,Nohara A,Satoh H

    更新日期:1991-10-24 00:00:00

  • Reduction and transport of lipoic acid by human erythrocytes.

    abstract::Reduction of exogenous lipoic acid to dihydrolipoate is known to occur in several mammalian cells and tissues. Dihydrolipoate is a potent radical scavenger, and may provide significant antioxidant protection. Because lipoic acid appears in the bloodstream after oral administration, we have examined the reduction of ex...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Constantinescu A,Pick U,Handelman GJ,Haramaki N,Han D,Podda M,Tritschler HJ,Packer L

    更新日期:1995-07-17 00:00:00

  • Inhibition of glycosaminoglycan synthesis in anatomically intact rat patellar cartilage by paracetamol-induced serum sulfate depletion.

    abstract::We have studied the effect of low sulfate concentrations on the glycosaminoglycan synthesis in rat patellar cartilage in vivo as well as in vitro. The oral administration of 200 mg/kg paracetamol to male Wistar rats resulted in a significant reduction of the serum sulfate concentration. Reduced serum sulfate availabil...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: van der Kraan PM,de Vries BJ,Vitters EL,van den Berg WB,van de Putte LB

    更新日期:1988-10-01 00:00:00

  • Valproate-induced hyperammonemia of renal origin. Effects of valproate on glutamine transport in rat kidney mitochondria.

    abstract::The antiepileptic sodium valproate (VPA) systematically induces an asymptomatic hyperammonemia of renal origin in fasting normal human volunteers and in fasting rats, accompanied by an increased renal glutamine uptake. Fasting rats were injected with VPA and their mitochondria isolated, or isolated mitochondria of fas...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Rumbach L,Cremel G,Marescaux C,Warter JM,Waksman A

    更新日期:1989-11-15 00:00:00

  • Stress-induced premature senescence and replicative senescence are different phenotypes, proteomic evidence.

    abstract::In this paper, we illustrate how a proteomic analysis can be useful to approach complex biological problems, in this case the concept of stress-induced premature senescence (SIPS). According to the stochastic theories of ageing, damage that accumulate with time in the cellular components are responsible for cellular a...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章,评审


    authors: Dierick JF,Eliaers F,Remacle J,Raes M,Fey SJ,Larsen PM,Toussaint O

    更新日期:2002-09-01 00:00:00