当前位置： SCI文献检索 > EPILEPSY RESEARCH期刊下所有文献 > 18FDG-PET in epilepsies of infantile onset with pharmacoresistant generalised tonic-clonic seizures.

18FDG-PET in epilepsies of infantile onset with pharmacoresistant generalised tonic-clonic seizures.

Abstract：

AIMS:To investigate the pathophysiology of pharmacoresistant epilepsies with cryptogenic generalised tonic-clonic seizures (GTCS) from infancy. METHODS:18F-Deoxy-Glucose-Positron Emission Tomography 18FDG-PET) with statistical parametric mapping (SPM). Inclusion criteria were: pharmacoresistant chronic epilepsy with GTCS commencing in infancy, no focal seizures except alternating hemiconvulsions and no focal epileptic discharges in the EEG during the first year of the disease, no focal changes upon routine neuroradiological investigations, no indication of brain damage according to history and clinical examination. RESULTS:15 boys and 15 girls with a mean age of 6.4 years (range l-14 years) were included. All still suffered from seizures despite past treatment with a mean of five drugs. Nearly all were mentally retarded, 19 to a severe and 10 to a minor degree. Fifteen were ataxic and 11 hypotonic. The EEG in 23 showed irregular generalised spike-wave discharges. PET SPM analysis revealed bioccipital hypometabolism related to sedation. Pathological monofocal hypometabolic areas were found in three, multifocal hypometabolic areas in 22 and diffuse bilateral hypometabolism in three patients. Frontal hypometabolism correlated to the degree of mental retardation, hypotonia, and ataxia. Temporomesial hypometabolism correlated to the occurrence of obtunded states and prominent delta rhythms in the EEG. Central and parietal changes were associated with the occurrence of myoclonic seizures and spike-wave discharges. CONCLUSIONS:18FDG-PET in many of these children with cryptogenic generalised epilepsies showed multifocal hypometabolic areas of unknown aetiology. Primary cortical microdysgenesis and secondary changes due to the severe and long-standing epilepsy must be considered. Only a minority of patients showed restricted focal hypometabolism as a possible indication for surgical treatment.

journal_name

Epilepsy Res

journal_title

Epilepsy research

authors

Korinthenberg R,Bauer-Scheid C,Burkart P,Martens-Le Bouar H,Kassubek J,Juengling FD

doi

10.1016/j.eplepsyres.2004.05.006

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

53-61

issue

1

eissn

0920-1211

issn

1872-6844

pii

S0920121104000956

journal_volume

60

pub_type

杂志文章

相关文献

EPILEPSY RESEARCH文献大全
  • Introduction to zonisamide.

    abstract：:Zonisamide (Zonegran), a novel antiepileptic drug (AED) approved recently in Europe as adjunctive therapy for refractory partial seizures in adults, has been used extensively in Japan and the United States. A substantial body of clinical experience has accumulated over a 14-year period, allowing the properties and pha...

    journal_title：Epilepsy research

    pub_type： 杂志文章,评审

    doi：10.1016/j.eplepsyres.2005.11.004

    authors： Baulac M

    更新日期：2006-02-01 00:00:00

  • The electrophysiological effects of multiple subpial transection (MST) in an experimental model of epilepsy induced by cortical stimulation.

    abstract：:Multiple subpial transection (MST) is an effective surgical therapy for patients with intractable seizures whose epileptogenic lesions lie in the cortex and are unresectable. Morrell developed this procedure and reported clinical results obtained using it. However, only the disappearance of epileptiform discharges aft...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/0920-1211(95)00003-s

    authors： Sugiyama S,Fujii M,Ito H

    更新日期：1995-05-01 00:00:00

  • Topiramate as add-on drug in children, adolescents and young adults with Lennox-Gastaut syndrome: an Italian multicentric study.

    abstract：:The purpose of the study was to evaluate the efficacy and safety of topiramate (TPM) as adjunctive therapy in children, adolescents and young adults with Lennox-Gastaut syndrome (LGS). We performed a prospective open label add-on study in 45 patients (age 4-34 years, mean 15.9 years) with LGS and refractory seizures. ...

    journal_title：Epilepsy research

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0920-1211(02)00103-1

    authors： Coppola G,Caliendo G,Veggiotti P,Romeo A,Tortorella G,De Marco P,Pascotto A

    更新日期：2002-09-01 00:00:00

  • Convulsant action of systemically administered glutamate and bicuculline methiodide in immature rats.

    abstract：:Developmental changes of transport of drugs into the brain play an important role in ontogenetic neuropharmacology. Two convulsant drugs with different mechanisms of action (glutamate and bicuculline methiodide) were chosen to demonstrate these changes in developing rats. High dose of glutamate (4 g/kg i.p.) induced b...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/s0920-1211(00)00179-0

    authors： Mares P,Chino M,Kubová H,Mathern P,Veliký M

    更新日期：2000-12-01 00:00:00

  • Association of anticonvulsant hypersensitivity syndrome with Herpesvirus 6, 7.

    abstract：BACKGROUND:Anticonvulsant hypersensitivity syndrome (AHS) is one of the most severe forms of drug eruption with potentially lethal, and multiorgan involvement. Recently, it has been suggested that Human Herpesvirus (HHV) infection has been involved in this syndrome, although the pathogenesis of this syndrome remains st...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2006.02.006

    authors： Oskay T,Karademir A,Ertürk OI

    更新日期：2006-07-01 00:00:00

  • Levetiracetam effect on behavioral and electrophysiological parameters in rat model of global brain ischemia.

    abstract：:Post-stroke paroxysmal activity is a neurophysiological indicator of epileptogenesis and increase of seizure susceptibility, so treatments with neuroprotective activity and anti-paroxysmal activity can be more beneficial during post-ischemic period. The goal of this study was evaluation of levetiracetam (100 mg/kg, 7 ...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2020.106466

    authors： Litvinova SA,Kutepova IS,Voronina TA,Petrunina АА

    更新日期：2020-11-01 00:00:00

  • The incidence of seizures in patients undergoing therapeutic hypothermia after resuscitation from cardiac arrest.

    abstract：STUDY OBJECTIVE:Non-convulsive seizures/status epilepticus occur in approximately 20% of comatose, non-cardiac arrest intensive care unit (ICU) patients, and are associated with increased mortality. The prevalence and clinical significance of seizures in comatose survivors of cardiac arrest undergoing therapeutic hypot...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2013.06.018

    authors： Knight WA,Hart KW,Adeoye OM,Bonomo JB,Keegan SP,Ficker DM,Szaflarski JP,Privitera MD,Lindsell CJ

    更新日期：2013-10-01 00:00:00

  • Preclinical characterization of MDL 27,192 as a potential broad spectrum anticonvulsant agent with neuroprotective properties.

    abstract：:The compound 5-(4-chlorophenyl)-2,4-dihydro-4-ethyl-3H-1,2,4-triazol-3-one (MDL 27,192) was evaluated in a variety of rodent models to assess its anticonvulsant profile and its potential neuroprotective activity. MDL 27,192 demonstrated anticonvulsant activity in a wide range of epilepsy models that are genetically-ba...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/s0920-1211(96)01020-0

    authors： Kehne JH,Kane JM,Chaney SF,Hurst G,McCloskey TC,Petty MA,Senyah Y,Wolf HH,Zobrist R,White HS

    更新日期：1997-04-01 00:00:00

  • Effects of levetiracetam as a monotherapy on bone mineral density and biochemical markers of bone metabolism in patients with epilepsy.

    abstract：PURPOSE:Antiepileptic drugs (AEDs) may have adverse effects on bone metabolism and bone mineral density (BMD). The aim of this study is to determine the changes of bone metabolism and BMD in epilepsy patients who are undergoing levetiracetam (LEV) monotherapy. METHODS:Drug-naïve, sixty-one patients with recent onset e...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2012.09.002

    authors： Koo DL,Joo EY,Kim D,Hong SB

    更新日期：2013-03-01 00:00:00

  • Association of nonsense mutation in GABRG2 with abnormal trafficking of GABAA receptors in severe epilepsy.

    abstract：:Mutations in GABRG2, which encodes the γ2 subunit of GABAA receptors, can cause both genetic epilepsy with febrile seizures plus (GEFS+) and Dravet syndrome. Most GABRG2 truncating mutations associated with Dravet syndrome result in premature termination codons (PTCs) and are stably translated into mutant proteins wit...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2013.12.005

    authors： Ishii A,Kanaumi T,Sohda M,Misumi Y,Zhang B,Kakinuma N,Haga Y,Watanabe K,Takeda S,Okada M,Ueno S,Kaneko S,Takashima S,Hirose S

    更新日期：2014-03-01 00:00:00

  • Cortical somatosensory evoked potentials of seizure-sensitive and seizure-resistant gerbils.

    abstract：:The Mongolian gerbil is known as an animal model that often exhibits spontaneous seizures that are characteristic of human epilepsy. Whereas there is much more information available relating this phenomenon to anatomical and electrophysiological characteristics of the hippocampal formation, the somatosensory cortex ha...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/s0920-1211(00)00116-9

    authors： Kato M,Ito M,Seto-Ohshima A

    更新日期：2000-07-01 00:00:00

  • Acute vagus nerve stimulation does not suppress spike and wave discharges in genetic absence epilepsy rats from Strasbourg.

    abstract：:We evaluated the efficacy of vagus nerve stimulation (VNS) in Genetic Absence Epilepsy Rats from Strasbourg (GAERS), a validated model for absence epilepsy. In the first experiment, we investigated whether VNS applied at seizure onset can interrupt spike and wave discharges (SWD). In the second experiment, we investig...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2004.04.005

    authors： Dedeurwaerdere S,Vonck K,Claeys P,Van Hese P,D'Havé M,Grisar T,Naritoku D,Boon P

    更新日期：2004-04-01 00:00:00

  • Increased membrane shedding--indicated by an elevation of CD133-enriched membrane particles--into the CSF in partial epilepsy.

    abstract：PURPOSE:Recent analyses provided evidence that human adult cerebrospinal fluid (CSF) in addition to soluble proteins also contains membrane particles that moreover carry the somatic stem cell marker CD133. The significance of CD133 as a potential marker of cellular proliferation, including neurogenesis, remains unresol...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2011.10.029

    authors： Huttner HB,Corbeil D,Thirmeyer C,Coras R,Köhrmann M,Mauer C,Kuramatsu JB,Kloska SP,Doerfler A,Weigel D,Klucken J,Winkler J,Pauli E,Schwab S,Hamer HM,Kasper BS

    更新日期：2012-03-01 00:00:00

  • Effects of valproate on glutamate metabolism in rat brain slices: a (13)C NMR study.

    abstract：:Sodium valproate is a drug widely used for the treatment of epilepsy and mood disorders. We studied the effect of valproate on cerebral energy metabolism by incubating rat brain slices with 5 mM [3-(13)C]glutamate in the absence and the presence of 1 mM valproate. Substrate removal and product formation were measured ...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2011.10.028

    authors： El Hage M,Baverel G,Martin G

    更新日期：2012-03-01 00:00:00

  • Risk factors for post-stroke seizures: a systematic review and meta-analysis.

    abstract：PURPOSE:To perform a systematic review and meta-analysis to identify risk factors associated with early seizure (ES) or late seizure (LS) onset in adults following stroke. DATA SOURCES:Electronic databases (MEDLINE and EMBASE), archives of stroke or epilepsy patients, and bibliographies of relevant articles, which wer...

    journal_title：Epilepsy research

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.eplepsyres.2014.09.030

    authors： Zhang C,Wang X,Wang Y,Zhang JG,Hu W,Ge M,Zhang K,Shao X

    更新日期：2014-12-01 00:00:00

  • Emergent network topology at seizure onset in humans.

    abstract：:Epilepsy - the world's most common serious brain disorder - is defined by recurrent unprovoked seizures that result from complex interactions between distributed neural populations. We explore some macroscopic characteristics of emergent ictal networks by considering intracranial recordings from human subjects with in...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2008.02.002

    authors： Kramer MA,Kolaczyk ED,Kirsch HE

    更新日期：2008-05-01 00:00:00

  • Seletracetam enhances short term depression in vitro.

    abstract：:Seletracetam (SEL), an analog of the antiepileptic drug levetiracetam (LEV), decreases seizure activity in a number of epilepsy models and binds to the synaptic vesicle protein SV2A with a higher affinity than LEV. Experiments were performed to determine if SEL, like LEV, reduces the later EPSPs in long trains of stim...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2015.08.006

    authors： Yang X,Meehan AL,Rothman SM,Dubinsky JM

    更新日期：2015-11-01 00:00:00

  • 30 years of vagus nerve stimulation trials in epilepsy: Do we need neuromodulation-specific trial designs?

    abstract：:Neuromodulation therapies represent an important treatment arm for patients with drug-resistant epilepsy (DRE) who are not candidates for resective surgery. Vagus nerve stimulation (VNS) - the neurostimulation modality in focus in this review - was the first available neuromodulatory therapy for DRE and was followed b...

    journal_title：Epilepsy research

    pub_type： 历史文章,杂志文章,评审

    doi：10.1016/j.eplepsyres.2019.02.004

    authors： Dibué-Adjei M,Kamp MA,Vonck K

    更新日期：2019-07-01 00:00:00

  • The long-term retention of pregabalin in a large cohort of patients with epilepsy at a tertiary referral centre.

    abstract：:Pregabalin (PGB) is a new antiepileptic drug (AED) which is a structural, non-functional analogue of gamma-aminobutyric acid. It acts at presynaptic calcium channels to modulate neurotransmitter release in the CNS. While the efficacy and tolerability of PGB have been demonstrated in several randomised controlled trial...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2009.08.001

    authors： Yuen AW,Singh R,Bell GS,Bhattacharjee A,Neligan A,Heaney DC,Duncan JS,Sander JW

    更新日期：2009-12-01 00:00:00

  • Selective amygdalohippocampectomy versus standard temporal lobectomy in patients with mesiotemporal lobe epilepsy and unilateral hippocampal sclerosis: post-operative facial emotion recognition abilities.

    abstract：:Surgical treatment of mesial temporal lobe epilepsy (mTLE) patients involves the removal either of the left or the right hippocampus. Since the mesial temporal lobe is responsible for emotion recognition abilities, we aimed to assess facial emotion recognition (FER) in two homogeneous patient cohorts that differed onl...

    journal_title：Epilepsy research

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.eplepsyres.2015.01.002

    authors： Wendling AS,Steinhoff BJ,Bodin F,Staack AM,Zentner J,Scholly J,Valenti MP,Schulze-Bonhage A,Hirsch E

    更新日期：2015-03-01 00:00:00

  • Transition to seizure in photosensitive epilepsy.

    abstract：:Photosensitive epilepsy (PSE) offers a highly reproducible model to investigate whether changes in neuronal activity preceding the transition to an epileptic photoparoxysmal response (PPR) may be detected. We investigated this possibility in patients with idiopathic PSE using MEG, as well as normal controls and non-ph...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2011.10.022

    authors： Lopes da Silva FH,Harding GF

    更新日期：2011-12-01 00:00:00

  • Urolithiasis on the ketogenic diet with concurrent topiramate or zonisamide therapy.

    abstract：:Children with refractory epilepsy who are co-treated with the ketogenic diet (KD) and carbonic anhydrase inhibitor (CA-I) anti-epileptic medications including topiramate (TPM) and zonisamide (ZNS) are at risk for urolithiasis. Retrospective chart review of all children treated with ketogenic therapy at our institution...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2010.04.005

    authors： Paul E,Conant KD,Dunne IE,Pfeifer HH,Lyczkowski DA,Linshaw MA,Thiele EA

    更新日期：2010-06-01 00:00:00

  • Genetic heterogeneity in infantile spasms.

    abstract：:Infantile spasms (IS) is a developmental and epileptic encephalopathy with heterogeneous etiologies including many genetic causes. Genetic studies have identified pathogenic variants in over 30 genes as causes of IS. Many of these genetic causes are extremely rare, with only one reported incidence in an individual wit...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2019.106181

    authors： Muir AM,Myers CT,Nguyen NT,Saykally J,Craiu D,De Jonghe P,Helbig I,Hoffman-Zacharska D,Guerrini R,Lehesjoki AE,Marini C,Møller RS,Serratosa J,Štěrbová K,Striano P,von Spiczak S,Weckhuysen S,Mefford HC,EuroEPINOMICS-RE

    更新日期：2019-10-01 00:00:00

  • Self-limited epilepsy with centro-temporal spikes: A study of 46 patients with unusual clinical manifestations.

    abstract：PURPOSE:We retrospectively analyzed the seizure characteristics, EEG pattern, treatment, and outcome in a series of patients with self-limited epilepsy with centrotemporal spikes (SLECTS) who presented with unusual clinical manifestations. METHOD:A retrospective, descriptive, multicenter study was conducted evaluating...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2020.106507

    authors： Galicchio S,Espeche A,Cersosimo R,Chacon S,Gamboni B,Adi J,Fasulo L,Semprino M,Fortini S,Cachia P,Caraballo RH

    更新日期：2021-01-01 00:00:00

  • Pharmacokinetics, exposure-cognition, and exposure-efficacy relationships of perampanel in adolescents with inadequately controlled partial-onset seizures.

    abstract：OBJECTIVE:To characterize, in adolescents aged 12-17, the pharmacokinetic (PK) profile of perampanel, the impact of intrinsic and extrinsic factors on PK, and the relationships between perampanel exposure and cognitive function, seizure frequency, and responder status. METHODS:Population PK analysis used plasma concen...

    journal_title：Epilepsy research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.eplepsyres.2016.08.025

    authors： Villanueva V,Majid O,Nabangchang C,Yang H,Laurenza A,Ferry J,Hussein Z

    更新日期：2016-11-01 00:00:00

  • The role of SLC2A1 in early onset and childhood absence epilepsies.

    abstract：:Early Onset Absence Epilepsy constitutes an Idiopathic Generalized Epilepsy with absences starting before the age of four years. Mutations in SLC2A1, encoding the glucose transporter, account for approximately 10% of EOAE cases. The role of SLC2A1 mutations in absence epilepsies with a later onset has not been assesse...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2012.11.004

    authors： Muhle H,Helbig I,Frøslev TG,Suls A,von Spiczak S,Klitten LL,Dahl HA,Brusgaard K,Neubauer B,De Jonghe P,Tommerup N,Stephani U,Hjalgrim H,Møller RS

    更新日期：2013-07-01 00:00:00

  • Validity of health insurance data to identify people with epilepsy.

    abstract：BACKGROUND:Large administrative databases may prove useful to assess epilepsy-related comorbidity and mortality. Despite their increased use, their validity as data source in epilepsy is yet under-ascertained. METHODS:Achmea is a large Dutch health insurance company covering about 25% of the population. We performed a...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2017.11.019

    authors： Wassenaar M,Carpay JA,Sander JW,Thijs RD

    更新日期：2018-01-01 00:00:00

  • Progress report on new antiepileptic drugs: a summary of the fourth Eilat conference (EILAT IV).

    abstract：:The Fourth Eilat Conference on New Antiepileptic Drugs (AEDs) was held at the Royal Beach Hotel, Eilat, Israel, from 6th to 10th September 1998. Epileptologists and scientists from 20 countries attended the conference, which was held to discuss a number of issues in drug development, including outcome assessment in ep...

    journal_title：Epilepsy research

    pub_type：

    doi：10.1016/s0920-1211(98)00108-9

    authors： Bialer M,Johannessen SI,Kupferberg HJ,Levy RH,Loiseau P,Perucca E

    更新日期：1999-03-01 00:00:00

  • Triheptanoin in acute mouse seizure models.

    abstract：:Triheptanoin, the triglyceride of heptanoate, is used to treat certain hereditary metabolic diseases in USA because of its anaplerotic potential. In two chronic mouse seizure models this clear tasteless oil was found to be reproducibly anticonvulsant. Here we investigated the effects of triheptanoin feeding in C3H and...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2011.12.013

    authors： Thomas NK,Willis S,Sweetman L,Borges K

    更新日期：2012-05-01 00:00:00

  • Brief asymmetric tonic posturing with diffuse low-voltage fast activity in seizures arising from the mesial parietal region.

    abstract：AIM:Seizures originating from the parietal lobe can demonstrate variable semiology. Our aim was to describe the electroclinical features of seizures originating from the mesial parietal lobe. METHOD:We identified four patients through the Comprehensive Epilepsy Program at our institution, who had strong evidence of a ...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2014.09.011

    authors： Khan SA,Carney PW,Archer JS

    更新日期：2014-12-01 00:00:00