Effects of phosphodiesterase inhibitors on interleukin-4 and interleukin-13 generation from human basophils.

abstract：:1. The effect of bradykinin on the Na+-K+ pump of airway smooth muscle was investigated by measuring ouabain-sensitive (86)Rb(+) uptake in cultured guinea-pig tracheal smooth muscle cells. 2. Bradykinin induced a concentration-dependent increase in ouabain-sensitive (86)Rb(+) uptake, with an EC(50) of 3 nM (pD(2) = 8....

journal_title：British journal of pharmacology

authors： Dodson AM,Rhoden KJ

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Two of the most relevant unmet needs in epilepsy are represented by the development of disease-modifying drugs able to affect epileptogenesis and/or the study of related neuropsychiatric comorbidities. No systematic study has investigated the effects of chronic treatment with antipsychotics or an...

journal_title：British journal of pharmacology

authors： Citraro R,Leo A,De Fazio P,De Sarro G,Russo E

更新日期：2015-06-01 00:00:00

abstract：:1. General anaesthetics disrupt normal cell receptivity and responsiveness while sparing vital respiratory processes. Ultimate elucidation of the molecular basis of general anaesthesia presumes the identification of one or more subcellular components with appropriate sensitivity to the entire array of anaesthetics. 2....

journal_title：British journal of pharmacology

authors： LaBella FS,Chen QM,Stein D,Queen G

更新日期：1997-03-01 00:00:00

abstract：:1 The influence of the external calcium concentration on the effect of harmine 2 x 10(-5) M upon the guinea-pig atrial muscle was analysed. Transmembrane potentials of contractile fibres were measured during exposure to the drug at 30 degrees C. 2 In preparations superfused with 1.35 mM Ca2+-Tyrode solution and driven...

journal_title：British journal of pharmacology

authors： Carpentier RG

更新日期：1981-10-01 00:00:00

abstract：:1. We have previously shown that 11-keto boswellic acids (11-keto-BAs), the active principles of Boswellia serrata gum resins, activate p38 MAPK and p42/44(MAPK) and stimulate Ca(2+) mobilisation in human polymorphonuclear leucocytes (PMNL). 2. In this study, we attempted to connect the activation of MAPK and mobilisa...

journal_title：British journal of pharmacology

authors： Altmann A,Poeckel D,Fischer L,Schubert-Zsilavecz M,Steinhilber D,Werz O

更新日期：2004-01-01 00:00:00

abstract：:We compared the modulation of synaptic transmission by adenosine A(1) receptors in the hippocampus of aged (24 months) and young adult rats (6 weeks). The adenosine A(1) receptor agonist, N(6)-cyclopentyladenosine, was less potent (P:<0.05) to inhibit synaptic transmission in aged (EC(50)=53 nM) than young adult (EC(5...

journal_title：British journal of pharmacology

authors： Sebastião AM,Cunha RA,de Mendonça A,Ribeiro JA

更新日期：2000-12-01 00:00:00

abstract：:1. The in vitro hemisected spinal cord from young rat was used to investigate the mechanism of serotoninergic modulation of primary afferent-mediated synaptic transmission in the dorsal horn through activation of the 5-HT3 receptor. 2. Dorsal root-evoked excitatory post-synaptic potentials (DR-EPSPs) were recorded int...

journal_title：British journal of pharmacology

authors： Khasabov SG,Lopez-Garcia JA,Asghar AU,King AE

更新日期：1999-06-01 00:00:00

abstract：:The effects of 15-hydroperoxy metabolites of arachidonic acid on vascular tone were evaluated in the perfused mesenteric preparation, the isolated perfused lung and segments of pulmonary arteries of the rat. In the mesenteric preparation, precontracted with phenylephrine, both 15-hydroperoxy-5,8,11,13-eicosatetraenoic...

journal_title：British journal of pharmacology

authors： d'Alarcao M,Corey EJ,Cunard C,Ramwell P,Uotila P,Vargas R,Wroblewska B

更新日期：1987-07-01 00:00:00

abstract：:This work investigates the receptor acted upon by imidazoline compounds in the modulation of morphine analgesia. The effects of highly selective imidazoline ligands on the supraspinal antinociception induced by morphine in mice were determined. 2. Intracerebroventricular (i.c.v.) or subcutaneous (s.c.) administration ...

journal_title：British journal of pharmacology

authors： Sánchez-Blázquez P,Boronat MA,Olmos G,García-Sevilla JA,Garzón J

更新日期：2000-05-01 00:00:00

abstract：:1 The venom of the green mamba, Dendroaspis angusticeps, was tested for effects on neuromuscular transmission and skeletal muscle contractility in isolated phrenic nerve-hemidiaphragm preparations of the rat and mouse, chick biventer cervicis muscle preparations and in aneural cultures of embryonic chick skeletal musc...

journal_title：British journal of pharmacology

authors： Barrett JC,Harvey AL

更新日期：1979-10-01 00:00:00

abstract：:C-C chemokine receptor-1 (CCR1) has been implicated in mediating a variety of inflammatory conditions including multiple sclerosis and organ rejection. Although originally referred to as the MIP-1alpha/RANTES receptor, CCR1 is quite promiscuous and can be activated by numerous chemokines. We used radioligand binding a...

journal_title：British journal of pharmacology

authors： Chou CC,Fine JS,Pugliese-Sivo C,Gonsiorek W,Davies L,Deno G,Petro M,Schwarz M,Zavodny PJ,Hipkin RW

更新日期：2002-11-01 00:00:00

abstract：:1. The putative alpha 1-adrenoceptor subtypes of rat cerebral cortex membranes were characterized in binding. 2. Specific binding of [3H]-prazosin was saturable between 20-5000 pm. Scatchard plots of the binding data were non-linear, indicating the presence of two distinct affinity sites for prazosin (pKD, high = 10.1...

journal_title：British journal of pharmacology

authors： Oshita M,Kigoshi S,Muramatsu I

更新日期：1991-12-01 00:00:00

abstract：:1. The intravenous, subcutaneous and oral toxicity of ambenoxan in mice is reported.2. Ambenoxan is a centrally acting skeletal muscle relaxant shown to be effective in mice, rats, rabbits, dogs and monkeys without loss of the righting reflex.3. It had no peripheral neuromuscular blocking properties.4. Decerebrate rig...

journal_title：British journal of pharmacology

authors： Shapero M,Southgate PJ

更新日期：1970-02-01 00:00:00

abstract：:The basis of the maternal to foetal serum concentration gradient of dexamethasone was investigated in the rat on day 20 of gestation. The pregnant rat was assumed to behave as a two-compartment open model with one maternal and one foetal pool exchanging with each other and each to outside. Bolus injections of unlabell...

journal_title：British journal of pharmacology

authors： Varma DR

更新日期：1986-08-01 00:00:00

abstract：:1. In guinea-pigs previously sensitized with ovalbumin, the intra-plantar administration of the antigen induced dose-dependent and sustained oedema. An intense infiltrate of neutrophils and eosinophils was observed at the peak of the oedema (4 h). 2. Oedema induced by ovalbumin at the doses of 50 or 200 micrograms/paw...

journal_title：British journal of pharmacology

authors： da Motta JI,Cunha FQ,Vargaftig BB,Ferreira SH

更新日期：1994-05-01 00:00:00

abstract：:Association between staphylococcal infection and pathogenesis of upper airways disease has been reported. This study aimed to investigate the mechanisms underlying the rat pulmonary inflammation induced by airway exposure to staphylococcal enterotoxin A (SEA). SEA (0.3-10 ng trachea(-1)) caused dose-dependent neutroph...

journal_title：British journal of pharmacology

authors： Desouza IA,Franco-Penteado CF,Camargo EA,Lima CS,Teixeira SA,Muscará MN,De Nucci G,Antunes E

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:5-HT (serotonin) regulates various physiological functions, both directly and via enteric neurons. The present study investigated the role of endogenous 5-HT and 5-HT3 receptors in the pathogenic mechanisms involved in colonic inflammation, especially in relation to substance P (SP) and the neuro...

journal_title：British journal of pharmacology

authors： Utsumi D,Matsumoto K,Amagase K,Horie S,Kato S

更新日期：2016-06-01 00:00:00

abstract：:1. In urethane-anaesthetized guinea-pigs, under spontaneous respiration, indomethacin (1 mg kg-1 i.v., 10-45 min) approximately doubled the bronchoconstrictor effect (increase in airways resistance, R(aw)) of equieffective doses of histamine and 5-hydroxytryptamine (5-HT), but not that of acetylcholine or leukotriene ...

journal_title：British journal of pharmacology

authors： Mitchell HW,Adcock J

更新日期：1988-06-01 00:00:00

abstract：:1. We compared the relaxant effect of pituitary adenylate cyclase activating peptide (PACAP) 1-27 with that of a newly developed PACAP 1-27 analogue, [Arg15,20,21Leu17]-PACAP-Gly-Lys-Arg-NH2, in the guinea-pig trachea and primate bronchi in vitro (n = 4-5). 2. In the guinea-pig trachea precontracted by a submaximally ...

journal_title：British journal of pharmacology

authors： Yoshihara S,Lindén A,Kashimoto K,Nagano Y,Ichimura T,Nadel JA

更新日期：1997-08-01 00:00:00

abstract：:1. ICI D7114 is a novel, beta-adrenoceptor agonist which stimulates whole body oxygen consumption in conscious rats, cats and dogs and brown adipose tissue (BAT) activity in conscious rats. Treatment of rats with ICI D7114 stimulated oxygen consumption (ED50, 0.04 mg kg-1, p.o.) and BAT mitochondrial guanosine diphosp...

journal_title：British journal of pharmacology

authors： Holloway BR,Howe R,Rao BS,Stribling D,Mayers RM,Briscoe MG,Jackson JM

更新日期：1991-09-01 00:00:00

abstract：:The present study examined the ability of the selective imidazoline I(2)-site ligands 2-(-2-benzofuranyl)-2-imidazoline (2-BFI) and 2-[4,5-dihydroimidaz-2-yl]-quinoline (BU224) and selected monoamine oxidase (MAO) inhibitors to evoke locomotor activity in rats bearing a lesion of the nigrostriatal pathway. Male Spragu...

journal_title：British journal of pharmacology

authors： Macinnes N,Duty S

更新日期：2004-12-01 00:00:00

abstract：:The effects of intravenous sufentanil and pre-administration of N-methyl-D-aspartate (NMDA) receptor antagonists were tested on a reflex triggered by C-fibre activation. The reflex was elicited by electrical stimulation of the sural nerve and recorded from the ipsilateral biceps femoris muscle in halothane anaesthetiz...

journal_title：British journal of pharmacology

authors： Adam F,Gairard AC,Chauvin M,Le Bars D,Guirimand F

更新日期：2001-08-01 00:00:00

abstract：:1 The cardiovascular effects of the anthelmintic drug diethylcarbamazine citrate (DECC) were examined in cats anaesthetized with pentobarbitone. There were two quite distinct haemodynamic responses, an initial transient hypotension (occurring within 10 s of an intravenous injection) and a pronounced secondary hyperten...

journal_title：British journal of pharmacology

authors： Abaitey AK,Parratt JR

更新日期：1976-02-01 00:00:00

abstract：:1. Voltage-operated calcium channel (VOCC) antagonists are effective antihypertensive and antianginal agents but they also depress myocardial contractility. 2. We compared four L-type calcium channel antagonists, felodipine, nifedipine, amlodipine and verapamil and a relatively T-type selective calcium channel antagon...

journal_title：British journal of pharmacology

authors： Sarsero D,Fujiwara T,Molenaar P,Angus JA

更新日期：1998-09-01 00:00:00

abstract：:It has been hypothesized that in patients with benign prostatic hyperplasia, selective antagonism of the alpha1A-adrenoceptor-mediated contraction of lower urinary tract tissues may, via a selective relief of outlet obstruction, lead to an improvement in symptoms. The present study describes the alpha1-adrenoceptor (a...

journal_title：British journal of pharmacology

authors： Williams TJ,Blue DR,Daniels DV,Davis B,Elworthy T,Gever JR,Kava MS,Morgans D,Padilla F,Tassa S,Vimont RL,Chapple CR,Chess-Williams R,Eglen RM,Clarke DE,Ford AP

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Exposure to an acute stress inhibits gastric emptying and stimulates colonic transit via central neuropeptide Y (NPY) pathways; however, peripheral involvement is uncertain. The anxiogenic phenotype of NPY(-/-) mice is gender-dependent, raising the possibility that stress-induced gastrointestinal...

journal_title：British journal of pharmacology

authors： Forbes S,Herzog H,Cox HM

更新日期：2012-08-01 00:00:00

abstract：:1. We have taken advantage of our recent development of highly potent and specific phosphinic inhibitors of endopeptidase 3.4.24.15 to examine the putative contribution of the enzyme in the secretion of A beta by HK293 transfected cells overexpressing the wild type and the Swedish (Sw) double mutated form of beta APP7...

journal_title：British journal of pharmacology

authors： Chevallier N,Jiracek J,Vincent B,Baur CP,Spillantini MG,Goedert M,Dive V,Checler F

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Inhalation of the superantigen,staphylococcal enterotoxin B (SEB), leads to the activation of the host T and invariant natural killer (iNK) T cells, thereby resulting in acute lung inflammation and respiratory failure but the underlying mechanism(s) of disease remain elusive, with limited treatme...

journal_title：British journal of pharmacology

authors： Rieder SA,Nagarkatti P,Nagarkatti M

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Small conductance calcium-activated potassium (KCa 2.x) channels have a widely accepted canonical function in regulating cellular excitability. In this study, we address a potential non-canonical function of KCa 2.x channels in breast cancer cell survival, using in vitro models. EXPERIMENTAL APP...

journal_title：British journal of pharmacology

authors： Abdulkareem ZA,Gee JM,Cox CD,Wann KT

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Hydrogen sulphide (H2 S) is an endogenous gaseous signalling molecule with putative functions in gastrointestinal motility regulation. Characterization of H2 S effects on colonic motility is crucial to establish its potential use as therapeutic agent in the treatment of colonic disorders. EXPERI...

journal_title：British journal of pharmacology

authors： Gil V,Parsons S,Gallego D,Huizinga J,Jimenez M

更新日期：2013-05-01 00:00:00