The pharmacology of ambenoxan (2-(3',6'-dioxaheptyl)-aminomethyl-1:4-benzodioxane), a centrally acting muscle relaxant.

abstract：:Injection of carrageenan 1% (50 microl) in the mouse paw causes a biphasic response: an early inflammatory response that lasts 6 h and a second late response that peaks at 72 h, declining at 96 h. Only mice 7- or 8-week old, weighing 32-34 g, displayed a consistent response in both phases. In 8-week-old mice, myeloper...

journal_title：British journal of pharmacology

authors： Posadas I,Bucci M,Roviezzo F,Rossi A,Parente L,Sautebin L,Cirino G

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cannabidiol (CBD) has emerged as an interesting compound with therapeutic potential in several CNS disorders. However, whether it can modulate synaptic activity in the CNS remains unclear. Here, we have investigated whether CBD modulates synaptic transmission in rat hippocampal cultures and acute...

journal_title：British journal of pharmacology

authors： Ledgerwood CJ,Greenwood SM,Brett RR,Pratt JA,Bushell TJ

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:This study examined the antinociceptive effects of sinomenine in a rat model of postoperative pain. EXPERIMENTAL APPROACH:Male and female rats were subjected to a surgical incision in the right hind paw, and the von Frey filament test was used to measure mechanical hypersensitivity after drug or...

journal_title：British journal of pharmacology

authors： Zhu Q,Sun Y,Mao L,Liu C,Jiang B,Zhang W,Li JX

更新日期：2016-05-01 00:00:00

abstract：:1. To elucidate the role of thapsigargin-induced Ca2+ entry in endothelial cells in the regulation of vascular tone, changes in Ca2+ and force of smooth muscle were simultaneously monitored in fura-2-loaded strips of porcine renal artery. 2. During phenylephrine-induced sustained contraction, thapsigargin caused an en...

journal_title：British journal of pharmacology

authors： Ihara E,Hirano K,Nishimura J,Nawata H,Kanaide H

更新日期：1999-10-01 00:00:00

abstract：:The variety of factors and events involved in neurodegeneration renders the subject a major challenge. Neurodegenerative disorders include a number of different pathological conditions, which share similar critical metabolic processes, such as protein aggregation and oxidative stress, both of which are associated with...

journal_title：British journal of pharmacology

authors： Gaeta A,Hider RC

更新日期：2005-12-01 00:00:00

abstract：:1. A murine macrophage cell line, J774, expressed nitric oxide (NO) synthase activity in response to interferon-gamma (IFN-gamma, 10 u ml-1) plus lipopolysaccharide (LPS, 10 ng ml-1). The enzyme activity was first detectable 6 h after incubation, peaked at 12 h and became undetectable after 48 h. 2. The decline in the...

journal_title：British journal of pharmacology

authors： Assreuy J,Cunha FQ,Liew FY,Moncada S

更新日期：1993-03-01 00:00:00

abstract：:1. The possible roles of endothelial and smooth muscle cell hyperpolarization and nitric oxide (NO) in endothelium-dependent relaxation were examined in isolated rings of pig right coronary artery. 2. The effects of hyperpolarization were prevented with high K+ (30-125 mM), isotonic Krebs solutions. Functional antagon...

journal_title：British journal of pharmacology

authors： Kilpatrick EV,Cocks TM

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Lithocholic acid (LCA), the most toxic bile acid, induces cholestatic liver injury in rodents. We previously showed that LCA activates the oxidative stress-responsive nuclear factor (erythroid-2 like), factor 2 (Nrf2) in cultured liver cells, triggering adaptive responses that reduce cell injury....

journal_title：British journal of pharmacology

authors： Tan KP,Wood GA,Yang M,Ito S

更新日期：2010-11-01 00:00:00

abstract：:1. Experiments were performed with peptidase inhibitors on rabbit aortic strip preparations, to determine whether endogenous peptidase activity can influence the potency estimates for angiotensin receptor agonists and antagonists in this tissue. 2. Angiotensin II (A II) and angiotensin III (A III) both induced concent...

journal_title：British journal of pharmacology

authors： Robertson MJ,Cunoosamy MP,Clark KL

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In terms of postjunctional alpha(2)-adrenoceptors in the pulmonary circulation, no evidence is available with regard to the receptor subtypes mediating vasoconstriction. Therefore, we characterized the alpha(2)-adrenoceptor subtypes mediating contraction in isolated porcine pulmonary veins. EXPE...

journal_title：British journal of pharmacology

authors： Görnemann T,von Wenckstern H,Kleuser B,Villalón CM,Centurión D,Jähnichen S,Pertz HH

更新日期：2007-05-01 00:00:00

abstract：:1. Bradykinin (BK) and Lys-BK are peptides which are released at high nanomolar concentrations into the tear-film of ocular allergic patients. We hypothesized that these peptides may activate specific receptors on the ocular surface, especially the corneal epithelium (CE) and thus the CE cells may represent a potentia...

journal_title：British journal of pharmacology

authors： Wiernas TK,Griffin BW,Sharif NA

更新日期：1997-06-01 00:00:00

abstract：:1. Previous studies demonstrated that elevation of the extracellular calcium concentration during a prolonged exposure to a high concentration of carbachol reverses the staurosporine-induced decrease in the extent of endplate resensitization in voltage-clamped snake twitch fibres. The present studies were designed to ...

journal_title：British journal of pharmacology

authors： Hardwick JC,Parsons RL

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Non-invasive in vivo imaging of cannabinoid CB2 receptors using PET is pursued to study neuroinflammation. The purpose of this study is to evaluate the in vivo binding specificity of [18 F]MA3, a CB2 receptor agonist, in a rat model with local overexpression of human (h) CB2 receptors. METHODS:[...

journal_title：British journal of pharmacology

authors： Attili B,Celen S,Ahamed M,Koole M,Haute CVD,Vanduffel W,Bormans G

更新日期：2019-05-01 00:00:00

abstract：:In this study, the mechanism of nicotine-induced hippocampal acetylcholine (ACh) release in awake, freely moving rats was examined using in vivo microdialysis. Systemic administration of nicotine (0.4 mg kg(-1), s.c.) increased the levels of ACh in hippocampal dialysates. The nicotine-induced hippocampal ACh release w...

journal_title：British journal of pharmacology

authors： Reid RT,Lloyd GK,Rao TS

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Pancreatic islet transplantation is a promising therapeutic approach for Type 1 diabetes. A major prerequisite for the survival of grafted islets is a rapid revascularization after transplantation. Erythropoietin (EPO), the primary regulator of erythropoiesis, has been shown to promote angiogenes...

journal_title：British journal of pharmacology

authors： Menger MM,Nalbach L,Roma LP,Körbel C,Wrublewsky S,Glanemann M,Laschke MW,Menger MD,Ampofo E

更新日期：2020-04-01 00:00:00

abstract：:1. Intravenous administration of leukotriene C4 (LTC4) and LTD4 (1-10 nmol kg-1) caused a dose-dependent increase in secretion of glandular-kallikrein in the bronchial washings of guinea-pigs, as measured by cleavage of a synthetic substrate and the formation of kinin. LTC4 was more potent than LTD4 and pilocarpine wa...

journal_title：British journal of pharmacology

authors： Jin HY,Katori M,Majima M,Sunahara N

更新日期：1992-03-01 00:00:00

abstract：:The molecular mechanisms involved in veratridine-induced chromaffin cell death have been explored. We have found that exposure to veratridine (30 microM, 1 h) produces a delayed cellular death that reaches 55% of the cells 24 h after veratridine exposure. This death has the features of apoptosis as DNA fragmentation c...

journal_title：British journal of pharmacology

authors： Jordán J,Galindo MF,Calvo S,González-García C,Ceña V

更新日期：2000-08-01 00:00:00

abstract：:BACKGROUND AND PURPOSE The transepithelial absorption of Na(+) in the lungs is crucial for the maintenance of the volume and composition of epithelial lining fluid. The regulation of Na(+) transport is essential, because hypo- or hyperabsorption of Na(+) is associated with lung diseases such as pulmonary oedema or cys...

journal_title：British journal of pharmacology

authors： Althaus M,Urness KD,Clauss WG,Baines DL,Fronius M

更新日期：2012-07-01 00:00:00

abstract：:Some 865 genes in man encode G-protein-coupled receptors (GPCRs). The heterotrimeric guanine nucleotide-binding proteins (G-proteins) function to transduce signals from this vast panoply of receptors to effector systems including ion channels and enzymes that alter the rate of production, release or degradation of int...

journal_title：British journal of pharmacology

authors： Milligan G,Kostenis E

更新日期：2006-01-01 00:00:00

abstract：:1. The present study was designed to characterize the positive inotropic response to DPI 201-106 in isolated papillary muscle strips obtained from heart failure patients undergoing surgery. 2. The positive inotropic responses to isoprenaline and milrinone and cardiac beta-adrenoceptor density were also determined. 3. ...

journal_title：British journal of pharmacology

authors： Böhm M,Diet F,Kemkes B,Wankerl M,Erdmann E

更新日期：1989-09-01 00:00:00

abstract：:1 Tegaserod (Zelnorm) is a potent 5-hydroxytryptamine4 (5-HT4) receptor agonist with clinical efficacy in disorders associated with reduced gastrointestinal motility and transit. The present study investigated the interaction of tegaserod with 5-HT2 receptors, and compared its potency in this respect to its 5-HT4 rece...

journal_title：British journal of pharmacology

authors： Beattie DT,Smith JA,Marquess D,Vickery RG,Armstrong SR,Pulido-Rios T,McCullough JL,Sandlund C,Richardson C,Mai N,Humphrey PP

更新日期：2004-11-01 00:00:00

abstract：:1. Acute moderate hypoxia modifies the catalytic activity and expression of certain isoenzymes of hepatic cytochrome P450 (P450). The aim of this study was to document whether hypoxia affects hepatic P450 directly or through the release of serum mediators. 2. Rabbits were subjected to a FiO(2) of 8% for 48 h, sacrific...

journal_title：British journal of pharmacology

authors： Fradette C,Bleau AM,Pichette V,Chauret N,Du Souich P

更新日期：2002-11-01 00:00:00

abstract：:1. The potencies of some beta-adrenoreceptor blocking drugs in reducing noradrenaline uptake by the isolated heart were compared with their potencies in reducing the release of noradrenaline from the heart by tyramine.2. Of the drugs tested, propranolol, pronethalol and dichloroisoprenaline were the most potent in blo...

journal_title：British journal of pharmacology

authors： Foo JW,Jowett A,Stafford A

更新日期：1968-09-01 00:00:00

abstract：:1. Taxanes are antineoplastic drugs which have cardiovascular side effects of unknown mechanism. We investigated their influence on blood viscosity and erythrocyte morphology. 2. Whole blood was incubated in vitro with increasing concentrations of Taxol, Taxotere, paclitaxel (0-100 microM) and the vehicles Cremophor-E...

journal_title：British journal of pharmacology

authors： Mark M,Walter R,Meredith DO,Reinhart WH

更新日期：2001-11-01 00:00:00

abstract：:1. Rat spinal cord neurones grown in tissue culture were used to examine the electrophysiological effects of the neurokin in (NK)-selective agonists (pGlu6, Pro9) substance P(6-11) (septide; NK1, 10(-6)M) and (pGlu5, MePhe8, MeGly9)SP(1-7) (DiMe-C7; NK3, 10(-6)M). In addition, the effect of the neurokinin antagonist (...

journal_title：British journal of pharmacology

authors： Wienrich M,Reuss K,Harting J

更新日期：1989-11-01 00:00:00

abstract：:1. First developed as an antiallergic drug, tranilast inhibits chemical mediator release from mast cells. In the present study, we examine the effects of tranilast on angiogenesis in vitro and in vivo and discuss the application of tranilast for angiogenic diseases. 2. Tranilast inhibited significantly the proliferati...

journal_title：British journal of pharmacology

authors： Isaji M,Miyata H,Ajisawa Y,Takehana Y,Yoshimura N

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Botulinum toxin type A (BoNT/A) injections into hyperactive muscles provide effective treatment for spasticity and dystonias, presumably due to its local effects on extrafusal and intrafusal motor fibres. A recent discovery of toxin's retrograde axonal transport to CNS might suggest additional ac...

journal_title：British journal of pharmacology

authors： Matak I

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Glucagon-like peptide-1 (GLP-1) is an incretin hormone that regulates insulin biosynthesis and secretion in a glucose-dependent manner and has been reported to induce vasodilatation. Here, we examined the possible vasorelaxant effect of GLP-1 and its underlying mechanisms. EXPERIMENTAL APPROACH:...

journal_title：British journal of pharmacology

authors： Bangshaab M,Gutierrez A,Huynh KD,Knudsen JS,Arcanjo DDR,Petersen AG,Rungby J,Gejl M,Simonsen U

更新日期：2019-02-01 00:00:00

abstract：:1. To determine how pretreatment with sulphonylureas alters the beta cell function, mouse islets were cultured (18 - 20 h) without (controls) or with (test) 0.01 microM glibenclamide. Acute responses to glucose were then determined in the absence of glibenclamide. 2. Test islets were insensitive to drugs (sulphonylure...

journal_title：British journal of pharmacology

authors： Anello M,Gilon P,Henquin JC

更新日期：1999-08-01 00:00:00

abstract：:1. Gastric acid secretory responses to pentagastrin were characterized in the rat isolated gastric mucosa. In particular, the mechanisms underlying fade, declining response upon continued stimulation, and tachyphylaxis, progressively reduced responses upon repeated stimulation, were investigated. 2. Pentagastrin, 10(-...

journal_title：British journal of pharmacology

authors： Hirst BH,Holland J,Parsons ME,Price CA

更新日期：1988-12-01 00:00:00