Doping control from a global and national perspective.

Abstract:

:The practice of enhancing athletic performance through foreign substances was known from the earliest Olympic games. In 1967, the International Olympic Committee (IOC) established a Medical Commission responsible for developing a list of prohibited substances and methods. Drug tests were first introduced at the Olympic winter games in Grenoble and at the summer games in Mexico City in 1968. In February 1999, the IOC convened the World Conference on Doping in Sport in Lausanne, Switzerland. The Lausanne Declaration on Doping in Sport recommended creation of an International Anti-Doping Agency. The World Anti-Doping Agency (WADA) was formed in Lausanne, Switzerland on the basis of equal representation from the Olympic movement and public authorities. One of the mandates of WADA was to harmonize the Olympic antidoping code and develop a single code applicable and acceptable for all stakeholders. The world antidoping code developed by WADA included creation of several international standards (IS). The purpose of each IS was harmonization among antidoping organizations. The ISs were developed for laboratories, testing, the prohibited list, and for therapeutic use exemptions (TUE). The objective of this manuscript is to present a brief history of doping in sport and describe creation of WADA in 1999. The components of the World Anti-Doping code (in particular, the Therapeutic Use Exclusion program or TUE) is described. The WADA code defines a TUE as "permission to use, for therapeutic purposes, a drug or drugs which are otherwise prohibited in sporting competition." Experiences of the Canadian Centre for Ethics in Sport Doping Control Review Board are presented because this national TUE committee has been operational for over 12 years. The challenge of developing a rigorous global antidoping program requires acceptance of doping as a problem by sport organizations, athletes, and public authorities. Individual stakeholders must be prepared to preserve the values of sport, which means free from doping. This will require vigilance by all interested parties for the benefit of elite athletes and society overall.

journal_name

Ther Drug Monit

authors

Fraser AD

doi

10.1097/00007691-200404000-00015

subject

Has Abstract

pub_date

2004-04-01 00:00:00

pages

171-4

issue

2

eissn

0163-4356

issn

1536-3694

journal_volume

26

pub_type

历史文章,杂志文章
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    doi:10.1097/FTD.0000000000000542

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  • Effect of ofloxacin on the pharmacokinetics of a single intravenous theophylline dose.

    abstract::The effect of ofloxacin taken for 8 days (200 mg twice daily) on the pharmacokinetics of a single intravenous dose of theophylline (4.3 mg/kg over 15 min) was studied in a crossover procedure among seven healthy male volunteers. Theophylline concentrations were measured serially for 10 h by the immunofluorescence pola...

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    更新日期:1988-01-01 00:00:00

  • Possible interaction between acyclovir and antiepileptic treatment.

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    pub_type: 杂志文章

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    authors: Parmeggiani A,Riva R,Posar A,Rossi PG

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    更新日期:2005-04-01 00:00:00

  • Therapeutic drug monitoring for drugs used in the treatment of substance-related disorders: literature review using a therapeutic drug monitoring appropriateness rating scale.

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    pub_type: 杂志文章,评审

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    journal_title:Therapeutic drug monitoring

    pub_type: 杂志文章

    doi:10.1097/00007691-198512000-00007

    authors: Bourgeois BF,Wad N

    更新日期:1985-01-01 00:00:00

  • Mixed-effect modeling for detection and evaluation of drug interactions: digoxin-quinidine and digoxin-verapamil combinations.

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    pub_type: 临床试验,杂志文章

    doi:10.1097/00007691-199602000-00008

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    更新日期:1996-02-01 00:00:00

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    journal_title:Therapeutic drug monitoring

    pub_type: 杂志文章

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    更新日期:1994-08-01 00:00:00

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    pub_type: 杂志文章

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    authors: Datta P,Dasgupta A

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    pub_type: 杂志文章

    doi:

    authors: Höglund P,Nilsson LG

    更新日期:1989-09-01 00:00:00

  • Valproic acid binding to human serum and human placenta in vitro.

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    pub_type: 历史文章,杂志文章

    doi:10.1097/00007691-199512000-00002

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    更新日期:1995-12-01 00:00:00

  • Interaction of tricyclic antidepressants with cholestyramine in vitro.

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    pub_type: 杂志文章

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    更新日期:1992-08-01 00:00:00

  • A rapid and simple microassay for lidocaine in human blood plasma using gas-liquid chromatography with nitrogen detection.

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    journal_title:Therapeutic drug monitoring

    pub_type: 杂志文章

    doi:10.1097/00007691-198102000-00010

    authors: Gal J,Freedman MD,Kumar E,Freed CR

    更新日期:1981-01-01 00:00:00

  • Safe management of tacrolimus together with posaconazole in lung transplant patients with cystic fibrosis.

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    journal_title:Therapeutic drug monitoring

    pub_type: 杂志文章

    doi:10.1097/FTD.0b013e31819de6fd

    authors: Berge M,Chevalier P,Benammar M,Guillemain R,Amrein C,Lefeuvre S,Boussaud V,Billaud EM

    更新日期:2009-06-01 00:00:00

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    journal_title:Therapeutic drug monitoring

    pub_type: 临床试验,杂志文章,随机对照试验

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  • The role of proton pump inhibitors on early mycophenolic acid exposure in kidney transplantation: evidence from the CLEAR study.

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    journal_title:Therapeutic drug monitoring

    pub_type: 杂志文章,多中心研究,随机对照试验

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    更新日期:2011-02-01 00:00:00

  • Low oral bioavailability and pharmacokinetics of senkyunolide a, a major bioactive component in Rhizoma Chuanxiong, in the rat.

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    journal_title:Therapeutic drug monitoring

    pub_type: 杂志文章

    doi:10.1097/FTD.0b013e31802c5862

    authors: Yan R,Lin G,Ko NL,Tam YK

    更新日期:2007-02-01 00:00:00

  • Reliable and Easy-To-Use Liquid Chromatography-Tandem Mass Spectrometry Method for Simultaneous Analysis of Fluconazole, Isavuconazole, Itraconazole, Hydroxy-Itraconazole, Posaconazole, and Voriconazole in Human Plasma and Serum.

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    journal_title:Therapeutic drug monitoring

    pub_type: 杂志文章

    doi:10.1097/FTD.0000000000000438

    authors: Müller C,Gehlen D,Blaich C,Prozeller D,Liss B,Streichert T,Wiesen MHJ

    更新日期:2017-10-01 00:00:00

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    journal_title:Therapeutic drug monitoring

    pub_type: 杂志文章

    doi:10.1097/00007691-199706000-00019

    authors: Laizure SC,Madlock L,Cyr M,Self T

    更新日期:1997-06-01 00:00:00

  • Overview of sotrastaurin clinical pharmacokinetics.

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    journal_title:Therapeutic drug monitoring

    pub_type: 杂志文章,评审

    doi:10.1097/FTD.0b013e3181ee9e26

    authors: Kovarik JM,Slade A

    更新日期:2010-10-01 00:00:00

  • Possible interaction between cyclosporine and glibenclamide in posttransplant diabetic patients.

    abstract::The possible occurrence of a kinetic interaction between cyclosporine A and glibenclamide was assessed by reviewing data of six posttransplant diabetic patients who received the two drugs concurrently. Coadministration of the two drugs resulted in a 57% increase in the steady-state plasma cyclosporine levels despite n...

    journal_title:Therapeutic drug monitoring

    pub_type: 杂志文章

    doi:10.1097/00007691-199610000-00017

    authors: Islam SI,Masuda QN,Bolaji OO,Shaheen FM,Sheikh IA

    更新日期:1996-10-01 00:00:00

  • Haloperidol plasma level monitoring in pediatric patients.

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    journal_title:Therapeutic drug monitoring

    pub_type: 杂志文章

    doi:10.1097/00007691-197901000-00004

    authors: Morselli PL,Bianchetti G,Durand G,Le Heuzey MF,Zarifian E,Dugas M

    更新日期:1979-01-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1097/00007691-200302000-00013

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    更新日期:2003-02-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1097/FTD.0000000000000157

    authors: Du S,Harenberg J,Krämer S,Krämer R,Wehling M,Weiss C

    更新日期:2015-06-01 00:00:00

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    journal_title:Therapeutic drug monitoring

    pub_type: 杂志文章

    doi:10.1097/00007691-199608000-00007

    authors: Pirsch JD,Sollinger HW

    更新日期:1996-08-01 00:00:00

  • Sources of Variability and Accuracy of Performance Assessment in the Clinical Pharmacology Quality Assurance Proficiency Testing Program for Antiretrovirals.

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    journal_title:Therapeutic drug monitoring

    pub_type: 杂志文章

    doi:10.1097/FTD.0000000000000612

    authors: Browne RW,Rosenkranz SL,Wang Y,Taylor CR,DiFrancesco R,Morse GD

    更新日期:2019-08-01 00:00:00

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    journal_title:Therapeutic drug monitoring

    pub_type: 杂志文章

    doi:10.1097/00007691-199404000-00016

    authors: Wright AW,Watt JA,Kennedy M,Cramond T,Smith MT

    更新日期:1994-04-01 00:00:00

  • Effect of associated antiepileptic treatment on valproate-induced hyperammonemia.

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    pub_type: 杂志文章

    doi:10.1097/00007691-198506000-00008

    authors: Zaccara G,Paganini M,Campostrini R,Moroni F,Valenza T,Messori A,Bartelli M,Arnetoli G,Zappoli R

    更新日期:1985-01-01 00:00:00