Abstract:
OBJECTIVES:To describe the seroepidemiology of herpes simplex virus (HSV) types 1 and 2 in the general populations of eight European countries to better understand recent reported changes in disease epidemiology. METHODS:Belgium, Bulgaria, Czech Republic, England and Wales, Finland, Germany, Netherlands, and Slovenia conducted national cross sectional serological surveys for HSV-1 and HSV-2 between 1989 and 2000. Survey sizes ranged from 3000 to 7166 sera. External quality control was ensured through reference panel testing. RESULTS:Large intercountry and intracountry differences in HSV-1 and HSV-2 seroprevalence were observed. Age standardised HSV-1 seroprevalence ranged from 52% in Finland, to 57% in the Netherlands, 67% in Belgium, 81% in Czech Republic, and 84% in Bulgaria. Age standardised (>12 years) HSV-2 seroprevalence ranged from 24% in Bulgaria, to 14% in Germany, 13% in Finland, 11% in Belgium, 9% in Netherlands, 6% in Czech Republic, and 4% in England and Wales. In all countries, probability of seropositivity for both infections increased with age. A large proportion of teenagers and young adults remain HSV-1 susceptible particularly in northern Europe. Women were significantly more likely to be HSV-2 seropositive in six of seven (p<0.05) countries and HSV-1 seropositive in four of seven (p<0.05) countries, particularly in northern Europe. No significant evidence of a protective role of HSV-1 for HSV-2 infection was found adjusting for age and sex (p<0.05). CONCLUSIONS:There is large variation in the seroepidemiology of HSV-1 and HSV-2 across Europe. The observation that a significant proportion of adolescents are now HSV-1 susceptible may have implications for transmission and clinical presentation of HSV-1 and HSV-2.
journal_name
Sex Transm Infectjournal_title
Sexually transmitted infectionsauthors
Pebody RG,Andrews N,Brown D,Gopal R,De Melker H,François G,Gatcheva N,Hellenbrand W,Jokinen S,Klavs I,Kojouharova M,Kortbeek T,Kriz B,Prosenc K,Roubalova K,Teocharov P,Thierfelder W,Valle M,Van Damme P,Vranckx Rdoi
10.1136/sti.2003.005850subject
Has Abstractpub_date
2004-06-01 00:00:00pages
185-91issue
3eissn
1368-4973issn
1472-3263journal_volume
80pub_type
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journal_title:Sexually transmitted infections
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doi:10.1136/sextrans-2018-053583
更新日期:2019-12-01 00:00:00
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journal_title:Sexually transmitted infections
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pub_type: 杂志文章,评审
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更新日期:2007-02-01 00:00:00
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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更新日期:2014-06-01 00:00:00
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更新日期:2011-03-01 00:00:00
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更新日期:2013-09-01 00:00:00
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更新日期:2015-03-01 00:00:00
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更新日期:2012-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-12-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2002-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-11-01 00:00:00
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journal_title:Sexually transmitted infections
pub_type: 杂志文章
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更新日期:2018-02-01 00:00:00
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journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2009.040766
更新日期:2010-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-02-01 00:00:00