Abstract:
:The aim of antiretroviral therapy in pregnancy is to deliver a healthy uninfected child to a healthy mother, without prejudicing the future treatment opportunities of the mother. The use of zidovudine monotherapy rapidly became standard practice once it had been shown to reduce by 67% mother to child transmission in women with CD4+ lymphocyte counts above 200 x 10(6)/l. High rates of transmission are seen when maternal disease is advanced (high viral load, low CD4+ lymphocyte counts) despite zidovudine. In these women highly active antiretroviral therapy gives the best prospect for prolonged health and it is anticipated that reducing plasma viral load below the limits of detection will further reduce transmission rates. However, safety data for antiretroviral therapy in pregnancy are limited and each additional treatment exposes a significant proportion of uninfected infants to potential long term hazards. Where maternal therapy is not indicated and the sole objective of treatment is to reduce mother to child transmission, recent data suggest that short course zidovudine (especially in conjunction with prelabour caesarean section) is a reasonable option. This may minimise the emergence of viruses with reduced sensitivity to zidovudine and preserve maternal options for later therapy.
journal_name
Sex Transm Infectjournal_title
Sexually transmitted infectionsauthors
Taylor GP,Lyall EG,Mercey D,Smith R,Chester T,Newell ML,Tudor-Williams Gdoi
10.1136/sti.75.2.90subject
Has Abstractpub_date
1999-04-01 00:00:00pages
90-7issue
2eissn
1368-4973issn
1472-3263journal_volume
75pub_type
杂志文章,评审abstract:OBJECTIVES:Biologically false positive (BFP) reactions are well described in early literature. However, only a few recent reports described the incidence and clinical characteristics of patients with BFP reactions. We reviewed the serological test results of patients tested for syphilis in our hospital in the past deca...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2020-054628
更新日期:2020-11-18 00:00:00
abstract:OBJECTIVE:To determine the characteristics of general practitioners (GPs) who test and patients who are tested for HIV in Australia. DESIGN AND SETTING:A secondary analysis of data from the Bettering the Evaluation and Care of Health programme; a cross-sectional, national survey of GP activity. METHODS:We identified ...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2011.049601
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVES:A community level randomised controlled trial of a Community Popular Opinion Leader (C-POL) intervention to reduce bacterial and viral sexually transmitted infections (STIs) and unprotected extramarital sex was carried out over 2 years in five countries. The main study results did not find significant interv...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/sti.2010.046243
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVES:To determine whether there is a link between age at first anal intercourse (AFAI) and gay men's HIV/sexually transmissible infection (STI) vulnerability, including tendencies to engage in higher risk sexual behaviour. METHODS:A nationwide cross-sectional survey was conducted online involving 845 Australian ...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2011-050253
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND AND HYPOTHESIS:Recently, the world has experienced a rapidly escalating outbreak of infectious syphilis primarily affecting men who have sex with men (MSM); many are taking highly active antiretroviral therapy (HAART) for HIV-1 infection. The prevailing hypothesis is that HAART availability and effectiveness...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,评审
doi:10.1136/sextrans-2016-052870
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVES:To measure prevalence of selected sexually transmitted infections (STI) and HIV among female sex workers (SWs) in the red light area of Surat, India, and to evaluate the performance of STI syndrome guidelines (for general population women in India) in this group against the standard aetiological diagnosis of...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.79.2.111
更新日期:2003-04-01 00:00:00
abstract:OBJECTIVES:Qualitative research suggests that young women's relationships with the biological fathers of their children (BFRs), known colloquially as 'baby daddy' relationships, enable risk for pregnancy and STI/HIV. Our study compared partner characteristics and sexual risk within dyads based on BFR, among a sample of...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2015-052157
更新日期:2016-06-01 00:00:00
abstract::In Asia Pacific, most countries have expanded HIV treatment guidelines to include all those with HIV infection and adopted antiretroviral treatment for prevention (TFP) as a blanket strategy for HIV control. Although the overall epidemic development associated with this focus is positive, the HIV epidemic in men who h...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,评审
doi:10.1136/sextrans-2016-052669
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:The Spectrum program is used to estimate key HIV indicators from the trends in incidence and prevalence estimated by the Estimation and Projection Package or the Workbook. These indicators include the number of people living with HIV, new infections, AIDS deaths, AIDS orphans, the number of adults and childr...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2010.044222
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVE:To evaluate sexual behaviour in 17 year old girls, using data from a national survey on adolescent sexuality. METHOD:The study was based on two samples of 17 year olds, comprising 2% of the population born in 1973 and carried out in 1990. A school sample and a sample of school non-attenders were recruited in...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.76.2.98
更新日期:2000-04-01 00:00:00
abstract:INTRODUCTION:In a systematic internet-based Chlamydia Screening Implementation Programme in The Netherlands, all chlamydia-positive participants automatically received a testkit after 6 months to facilitate early detection of repeat infections. The authors describe participation in repeat testing and prevalence and det...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2011-050455
更新日期:2013-02-01 00:00:00
abstract::The Indian Ocean provides a unique opportunity to curb the HIV epidemic in its nascent phase through strengthening STI control programmes. Making effective and appropriate health services available should be regarded as the first priority for STI control in the region and, whenever possible, core groups should be iden...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.78.suppl_1.i121
更新日期:2002-04-01 00:00:00
abstract:BACKGROUND:Vulvo-vaginal swabs (VVSs) are not validated for use by the manufacturers of two widely used nucleic acid amplification tests (NAAT) for the detection of Chlamydia trachomatis. However, there is evidence that this type of swab is suitable for diagnosis. OBJECTIVE:To validate the Cobas Taqman CT assay for th...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sti.2007.029587
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVE:To date, the epidemic of HIV infection in Scotland has been primarily associated with injecting drug use. However, the epidemiology of HIV in Scotland changed in the late 1980s, with homosexual men becoming the largest group at risk of HIV infection and AIDS. Our aim was to describe homosexual men's sexual ri...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.75.4.242
更新日期:1999-08-01 00:00:00
abstract:OBJECTIVES:Partner notification (PN) following sexually transmitted disease (STI) diagnosis is a key strategy for controlling HIV/STI transmission. Anonymous partnerships are an important barrier to PN and often associated with high-risk sexual behaviour. Limited research has examined the profile of men who have sex wi...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2015-052310
更新日期:2016-11-01 00:00:00
abstract::Qualitative methods have gained support in health sciences research and have a role to play in STI studies. This article reviews the main techniques used by qualitative researchers, with illustrations taken from the field of STIs. ...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,评审
doi:10.1136/sti.78.2.87
更新日期:2002-04-01 00:00:00
abstract:OBJECTIVES:HIV/AIDS risk is embodied within multiple levels including structural and social levels. The aim of this study was to assess the effects of neighbourhood characteristics on HIV prevalence among injection drug users (IDU) residing in the area of Tallinn, Estonia in 2007. METHODS:A cross-sectional, multilevel...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2009.040212
更新日期:2010-12-01 00:00:00
abstract::This review will delineate performance characteristics and limitations, as far as they are known, of the new glycoprotein G based, type specific HSV serologies. Several of these tests have been FDA approved in the United States for use in adults. With the departure of Gull/Meridian from the HSV serology market, it is ...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,评审
doi:10.1136/sti.77.4.232
更新日期:2001-08-01 00:00:00
abstract::Core groups contain individuals who are regularly infected with Neisseria gonorrhoeae and are able to transmit their infection to a large number of sexual partners. Classical core groups, such as sex workers and their male partners, or men who have sex with men (MSM), have contributed to the emergence and spread of an...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,评审
doi:10.1136/sextrans-2013-051020
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:The Sydney Sexual Health Centre in Australia uses a proforma tool to screen all new female clients for recent physical intimate partner violence (IPV). This study describes the prevalence and associations of recent physical IPV among women attending a sexual health clinic. METHOD:The clinic database was use...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2010.043109
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:To describe the impact of a repeating behavioural intervention focused on preventive education and provision of STD testing and treatment services to female sex workers. METHODS:A prospective cohort study of 966 sex workers (first of its kind in China) was conducted in Guangzhou from March 1998 to October 19...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.78.2.110
更新日期:2002-04-01 00:00:00
abstract:BACKGROUND:Poor knowledge regarding STI and HIV transmission, testing and treatment among men who have sex with men (MSM) may be contributing to their disproportionate burden of STIs. However, factors which predispose MSM to having this low knowledge are less understood. AIM:The aim of this study was to identify facto...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2020-054469
更新日期:2020-10-26 00:00:00
abstract:OBJECTIVE:To determine whether Mycoplasma genitalium is associated with balanitis and/or posthitis in a previous study of the role of M genitalium in men with acute non-gonococcal urethritis (NGU). METHODS:In a previous study of men with acute NGU, the existence of balanitis and/or posthitis was recorded. Chlamydia tr...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2010.044487
更新日期:2011-02-01 00:00:00
abstract::Forces at work are described which encourage professionalisation and a reliance on one on one HIV prevention interventions among gay men. Community involvement is intrinsically linked to epidemic phases; when the threat diminishes, so does the community's ability to sustain community level interventions. The area of s...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.78.suppl_1.i176
更新日期:2002-04-01 00:00:00
abstract:OBJECTIVES:During the last decades, a changing epidemiological pattern of genital herpes simplex virus (HSV) infection has emerged. Primary infection is now caused as often by HSV-1 as by HSV-2. Once established, HSV can be reactivated leading to recurrent mucocutaneous lesions as well as meningitis. Why some otherwise...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2016-052811
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVES:Oropharyngeal squamous cell carcinoma is the most common human papillomavirus (HPV)-associated cancer in the UK, but little is known about the prevalence of oropharyngeal HPV in sexually active teenagers. We investigated reported HPV vaccination coverage (in females) and prevalence of oropharyngeal HPV in se...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2020-054428
更新日期:2020-09-03 00:00:00
abstract:OBJECTIVES:To understand the factors associated with knowledge of non-occupational post-exposure prophylaxis (nPEP) and pre-exposure prophylaxis (PrEP), bathhouse patrons in New York City (NYC) were surveyed. METHODS:554 men who have sex with men (MSM) at two NYC bathhouses were given a standardised survey focused on ...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2010.046284
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:In England, people of black minority ethnicities are at elevated risk of STI diagnosis, especially those of black Caribbean (BC) heritage. Understanding the factors that predict STI acquisition in this population is key to inform prevention measures. We examined the differences in predictors of incident STI d...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2020-054784
更新日期:2021-01-29 00:00:00
abstract:OBJECTIVES:To link local proinflammatory cytokines with HIV related nucleic acids in cervico-vaginal secretions and the factors associated with them. METHODS:An observational study on 60 HIV positive women attending the department of obstetrics and gynaecology, University of Pavia, Italy. HIV-1 RNA in plasma, proviral...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2003.005157
更新日期:2004-04-01 00:00:00
abstract:OBJECTIVES:To identify the changes in sexual behaviour that led to the dramatic reduction in the prevalence of HIV in Uganda in the early 1990s. METHODS:Seven different types of evidence were examined: (1) models of HIV prevalence and incidence in Kampala and other sentinel sites in Uganda; (2) reports of behaviour ch...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sti.2008.029892
更新日期:2008-10-01 00:00:00