In vivo dynamics of Swi6 in yeast: evidence for a stochastic model of heterochromatin.

abstract：:The regulatory subunits of cyclic AMP (cAMP)-dependent protein kinase from a dibutyryl cAMP-resistant S49 mouse lymphoma cell mutant, clone U200/65.1, and its revertants were visualized by two-dimensional polyacrylamide gel electrophoresis. Clone U200/65.1 co-expressed electrophoretically distinguishable mutant and wi...

journal_title：Molecular and cellular biology

authors： van Daalen Wetters T,Coffino P

更新日期：1983-02-01 00:00:00

abstract：:Cytochrome P450 oxidoreductase (POR) is the obligate electron donor for all microsomal cytochrome P450 enzymes, which catalyze the metabolism of a wide spectrum of xenobiotic and endobiotic compounds. Point mutations in POR have been found recently in patients with Antley-Bixler-like syndrome, which includes limb skel...

journal_title：Molecular and cellular biology

authors： Schmidt K,Hughes C,Chudek JA,Goodyear SR,Aspden RM,Talbot R,Gundersen TE,Blomhoff R,Henderson C,Wolf CR,Tickle C

更新日期：2009-05-01 00:00:00

abstract：:Homeodomain proteins are transcriptional regulatory factors that, in general, bind DNA with relatively low sequence specificity and affinity. One mechanism homeodomain proteins use to increase their biological specificity is through interactions with other DNA-binding proteins. We have examined how the yeast (Saccharo...

journal_title：Molecular and cellular biology

authors： Mead J,Zhong H,Acton TB,Vershon AK

更新日期：1996-05-01 00:00:00

abstract：:The K-fgf/hst oncogene encodes a secreted growth factor of the fibroblast growth factor (FGF) family. The ability of K-fgf-transformed cells to grow in soft agar and in serum-free medium is inhibited by anti-K-FGF neutralizing antibodies, consistent with an autocrine mechanism of transformation. The transformed proper...

journal_title：Molecular and cellular biology

authors： Talarico D,Basilico C

更新日期：1991-02-01 00:00:00

abstract：:In Drosophila melanogaster, achaete (ac) and m8 are model basic helix-loop-helix activator (bHLH A) and repressor genes, respectively, that have the opposite cell expression pattern in proneural clusters during Notch signaling. Previous studies have shown that activation of m8 transcription in specific cells within pr...

journal_title：Molecular and cellular biology

authors： Cave JW,Xia L,Caudy M

更新日期：2011-01-01 00:00:00

abstract：:Glucocorticoids are stress hormones that maintain homeostasis through gene regulation mediated by nuclear receptors. We have discovered that other cellular stressors are integrated with glucocorticoid signaling through a new hormone-independent phosphorylation site, Ser134, on the human glucocorticoid receptor (GR). S...

journal_title：Molecular and cellular biology

authors： Galliher-Beckley AJ,Williams JG,Cidlowski JA

更新日期：2011-12-01 00:00:00

abstract：:Welander distal myopathy (WDM) is a muscle dystrophy characterized by adult-onset distal muscle weakness, prevalently impacting the distal long extensors of the hands and feet. WDM is an autosomal dominant disorder caused by a missense mutation (c.1362G>A; p.E384K) in the TIA1 (T-cell intracellular antigen 1) gene, wh...

journal_title：Molecular and cellular biology

authors： Carrascoso I,Sánchez-Jiménez C,Silion E,Alcalde J,Izquierdo JM

更新日期：2018-12-11 00:00:00

abstract：:The Rex protein of human T-cell leukemia virus type 1, like the functionally equivalent Rev protein of human immunodeficiency virus type 1, contains a leucine-rich activation domain that specifically interacts with the human nucleoporin-like Rab/hRIP cofactor. Here, this Rex sequence is shown to function also as a pro...

journal_title：Molecular and cellular biology

authors： Bogerd HP,Fridell RA,Benson RE,Hua J,Cullen BR

更新日期：1996-08-01 00:00:00

abstract：:Nrdp1 is a RING finger-containing E3 ubiquitin ligase that physically interacts with and regulates steady-state cellular levels of the ErbB3 and ErbB4 receptor tyrosine kinases and has been implicated in the degradation of the inhibitor-of-apoptosis protein BRUCE. Here we demonstrate that the Nrdp1 protein undergoes e...

journal_title：Molecular and cellular biology

authors： Wu X,Yen L,Irwin L,Sweeney C,Carraway KL 3rd

更新日期：2004-09-01 00:00:00

abstract：:Polyamines critically regulate all mammalian cell growth and proliferation by mechanisms such as the repression of growth-inhibitory proteins, including JunD. Decreasing the levels of cellular polyamines stabilizes JunD mRNA without affecting its transcription, but the exact mechanism whereby polyamines regulate JunD ...

journal_title：Molecular and cellular biology

authors： Zou T,Rao JN,Liu L,Xiao L,Yu TX,Jiang P,Gorospe M,Wang JY

更新日期：2010-11-01 00:00:00

abstract：:The Eph receptors are the largest known family of receptor tyrosine kinases and are notable for distinctive expression patterns in the nervous system and in early vertebrate development. However, all were identified as orphan receptors, and only recently have there been descriptions of a corresponding family of ligand...

journal_title：Molecular and cellular biology

authors： Bergemann AD,Cheng HJ,Brambilla R,Klein R,Flanagan JG

更新日期：1995-09-01 00:00:00

abstract：:SLC5A8 is a putative tumor suppressor that is inactivated in more than 10 different types of cancer, but neither the oncogenic signaling responsible for SLC5A8 inactivation nor the functional relevance of SLC5A8 loss to tumor growth has been elucidated. Here, we identify oncogenic HRAS (HRAS(G12V)) as a potent mediato...

journal_title：Molecular and cellular biology

authors： Elangovan S,Pathania R,Ramachandran S,Ananth S,Padia RN,Srinivas SR,Babu E,Hawthorn L,Schoenlein PV,Boettger T,Smith SB,Prasad PD,Ganapathy V,Thangaraju M

更新日期：2013-10-01 00:00:00

abstract：:The growth suppressor activities of the RB and p107 products are believed to be mediated by the reversible binding of a heterogeneous family of cellular proteins to a conserved T/E1A pocket domain that is present within both proteins. To study the functional role of these interactions, we examined the properties of ce...

journal_title：Molecular and cellular biology

authors： Kim YW,Otterson GA,Kratzke RA,Coxon AB,Kaye FJ

更新日期：1994-11-01 00:00:00

abstract：:The CYC1-239-O mutation in the yeast Saccharomyces cerevisiae produces a -His-Leu- replacement of the normal -Ala-Gly- sequence at amino acid positions 5 and 6, which lie within a dispensable region of iso-1-cytochrome c; this mutation can accommodate the formation of a hairpin structure at the corresponding site in t...

journal_title：Molecular and cellular biology

authors： Baim SB,Pietras DF,Eustice DC,Sherman F

更新日期：1985-08-01 00:00:00

abstract：:The catalytic function of Src-related tyrosine protein kinases is repressed by phosphorylation of a conserved carboxy-terminal tyrosine residue. Recent studies suggest that this inhibitory event is not the result of autophosphorylation but that it is mediated by another cytoplasmic tyrosine protein kinase, termed p50c...

journal_title：Molecular and cellular biology

authors： Gervais FG,Chow LM,Lee JM,Branton PE,Veillette A

更新日期：1993-11-01 00:00:00

abstract：:Ribosome biogenesis is a highly regulated process ensuring that cell growth (increase in biomass) is coordinated with cell proliferation. The formation of eukaryotic ribosomes is a multistep process initiated by the transcription and processing of rRNA in the nucleolus. Concomitant with this, several preribosomal part...

journal_title：Molecular and cellular biology

authors： Castle CD,Cassimere EK,Lee J,Denicourt C

更新日期：2010-09-01 00:00:00

abstract：:Toxoplasma gondii is an obligate intracellular pathogen within the phylum Apicomplexa. Invasion and egress by this protozoan parasite are rapid events that are dependent upon parasite motility and appear to be directed by fluctuations in intracellular [Ca(2+)]. Treatment of infected host cells with the calcium ionopho...

journal_title：Molecular and cellular biology

authors： Black MW,Arrizabalaga G,Boothroyd JC

更新日期：2000-12-01 00:00:00

abstract：:Fragments of 5'-flanking and noncoding exon I sequences of the human gastrin gene were analyzed in transient expression assays after transfection of a variety of cell lines with the pSVCAT vector system. In the presence of the simian virus 40 (SV40) enhancer, the gastrin gene fragment from nucleotides -250 to +57, rel...

journal_title：Molecular and cellular biology

authors： Theill LE,Wiborg O,Vuust J

更新日期：1987-12-01 00:00:00

abstract：:Drosophila hsp70 genes have an RNA polymerase II molecule paused at their 5' ends in uninduced cells. In this study we have shown that this pausing also occurs on other heat shock and constitutively expressed genes. We propose that a rate-limiting step in early elongation occurs in many Drosophila genes and may be a t...

journal_title：Molecular and cellular biology

authors： Rougvie AE,Lis JT

更新日期：1990-11-01 00:00:00

abstract：:The use of small-molecule inhibitors to study molecular components of cellular signal transduction pathways provides a means of analysis complementary to currently used techniques, such as antisense, dominant-negative (interfering) mutants and constitutively activated mutants. We have identified and characterized a sm...

journal_title：Molecular and cellular biology

authors： Blake RA,Broome MA,Liu X,Wu J,Gishizky M,Sun L,Courtneidge SA

更新日期：2000-12-01 00:00:00

abstract：:Unlike other eukaryotes, the protein-coding genes of Trypanosoma cruzi are arranged in large polycistronic gene clusters transcribed by polymerase II (Pol II). Thus, it is thought that trypanosomes rely solely on posttranscriptional processes to regulate gene expression. Here, we show that the glucosylated thymine DNA...

journal_title：Molecular and cellular biology

authors： Ekanayake DK,Minning T,Weatherly B,Gunasekera K,Nilsson D,Tarleton R,Ochsenreiter T,Sabatini R

更新日期：2011-04-01 00:00:00

abstract：:Furin is a subtilisin-related endoprotease which processes a wide range of bioactive proteins. Furin is concentrated in the trans-Golgi network (TGN), where proteolytic activation of many precursor proteins takes place. A significant fraction of furin, however, cycles among the TGN, the plasma membrane, and endosomes,...

journal_title：Molecular and cellular biology

authors： Simmen T,Nobile M,Bonifacino JS,Hunziker W

更新日期：1999-04-01 00:00:00

abstract：:The minimal muscle-specific dystrophin promoter contains the consensus sequence CC(A/T)6GG, or the CArG element, which can be found in serum-inducible or muscle-specific promoters. The serum response factor (SRF), which mediates the transcriptional activation of the c-fos gene in response to serum stimulation, can bin...

journal_title：Molecular and cellular biology

authors： Galvagni F,Lestingi M,Cartocci E,Oliviero S

更新日期：1997-03-01 00:00:00

abstract：:Human neuroblastoma cells often carry amplified DNA encompassing the gene N-myc. Amplified N-myc has been found localized in "double minutes" in direct tumor cell preparations. In contrast, later passages carried amplified N-myc almost exclusively within a single homogeneously staining chromosomal region located at a ...

journal_title：Molecular and cellular biology

authors： Amler LC,Schwab M

更新日期：1989-11-01 00:00:00

abstract：:The lck proto-oncogene encodes a lymphocyte-specific member of the src family of protein tyrosine kinases. Here we demonstrate that pp56lck is phosphorylated in vivo at a carboxy-terminal tyrosine residue (Tyr-505) analogous to Tyr-527 of pp60c-src. Substitution of phenylalanine for tyrosine at this position resulted ...

journal_title：Molecular and cellular biology

authors： Marth JD,Cooper JA,King CS,Ziegler SF,Tinker DA,Overell RW,Krebs EG,Perlmutter RM

更新日期：1988-02-01 00:00:00

abstract：:The upstream activating sequence of the adjacent and divergently transcribed GAL1 and GAL10 genes of Saccharomyces cerevisiae (UASG) contains at least three distinct classes of overlapping transcriptional control sites. The transcription activator GAL4 binds to four related sites in UASG and induces expression of GAL1...

journal_title：Molecular and cellular biology

authors： Finley RL Jr,West RW Jr

更新日期：1989-10-01 00:00:00

abstract：:Nuclear migration and positioning within cells are critical for many developmental processes and are governed by the cytoskeletal network. Although mechanisms of nuclear-cytoskeletal attachment are unclear, growing evidence links a novel family of nuclear envelope (NE) proteins that share a conserved C-terminal SUN (S...

journal_title：Molecular and cellular biology

authors： Haque F,Lloyd DJ,Smallwood DT,Dent CL,Shanahan CM,Fry AM,Trembath RC,Shackleton S

更新日期：2006-05-01 00:00:00

abstract：:Protein phosphatase 2A (PP2A) is a multimeric serine/threonine phosphatase that carries out multiple functions. Although numerous observations suggest that PP2A plays a major role in downregulation of the mitogen-activated protein (MAP) kinase pathway, the precise mechanisms are unknown. To clarify the role of PP2A in...

journal_title：Molecular and cellular biology

authors： Ugi S,Imamura T,Ricketts W,Olefsky JM

更新日期：2002-04-01 00:00:00

abstract：:Bcl10 is a critical regulator of NF-kappa B activity in T and B cells, coupling antigen receptor signaling to NF-kappa B activation via protein kinase C (PKC). Here we show that PKC or T-cell receptor (TCR)/CD28 signaling results in downregulation of Bcl10 protein levels, thereby attenuating NF-kappa B transcriptional...

journal_title：Molecular and cellular biology

authors： Scharschmidt E,Wegener E,Heissmeyer V,Rao A,Krappmann D

更新日期：2004-05-01 00:00:00

abstract：:We have analyzed the interleukin-4 (IL-4)-triggered mechanisms implicated in cell survival and show here that IL-4 deprivation induces apoptotic cell death but does not modulate Bcl-2 or Bcl-x expression. Since Bcl-x expression is insufficient to ensure cell survival in the absence of IL-4, we speculate that additiona...

journal_title：Molecular and cellular biology

authors： Rebollo A,Dumoutier L,Renauld JC,Zaballos A,Ayllón V,Martínez-A C

更新日期：2000-05-01 00:00:00