Clinical effects of botulinum toxin A and phenol block on gait in children with cerebral palsy.

Abstract:

OBJECTIVE:To compare the treatment effectiveness of botulinum toxin type A (BTX-A) and phenol blocks in managing lower limb spasticity and gait dysfunction in children with cerebral palsy. DESIGN:This is a case-controlled study that took place in a tertiary center's gait laboratory. A total of 27 ambulatory children with cerebral palsy spastic diplegia, aged from 3 to 7 yrs, and 20 normal children were recruited into this study. Sixteen children with cerebral palsy received BTX-A injections, and 11 received phenol motor point blocks. Gait analyses were assessed by a portable computer-assisted system (Computer DynoGraphy, Infotronic, The Netherlands). Both the BTX-A and phenol groups received gait analysis at 1 wk before and 2 mos after injection treatments. RESULTS:Significant improvements in gait variables of velocity and cadence were noted in children with cerebral palsy after BTX-A injections as compared with the phenol block group. Gaitline and cyclogram patterns also improved significantly in the BTX-A group. The adverse clinical effects of BTX-A injections were less severe as compared with phenol injections. CONCLUSIONS:BTX-A injections demonstrated superior treatment effects in improving gait variables and patterns in children with spastic diplegia as compared with phenol blocks. BTX-A injections also revealed fewer clinical side effects and were well tolerated by children with cerebral palsies.

journal_name

Am J Phys Med Rehabil

authors

Wong AM,Chen CL,Chen CP,Chou SW,Chung CY,Chen MJ

doi

10.1097/01.phm.0000118038.02326.ca

subject

Has Abstract

pub_date

2004-04-01 00:00:00

pages

284-91

issue

4

eissn

0894-9115

issn

1537-7385

pii

00002060-200404000-00008

journal_volume

83

pub_type

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