Vasorelaxation by red blood cells and impairment in diabetes: reduced nitric oxide and oxygen delivery by glycated hemoglobin.

abstract：:The microelectrode technique of intracellular constant current application and intracellular transmembrane voltage recording was used to study the effects of procaine amide (PA) on cardiac excitability. We measured the effect of PA in a concentration equivalent to clinically effective antiarrhythmic plasma levels (5 m...

journal_title：Circulation research

authors： Arnsdorf MF,Bigger JT Jr

更新日期：1976-02-01 00:00:00

abstract：:Gene therapy, aimed at the correction of key pathologies being out of reach for conventional drugs, bears the potential to alter the treatment of cardiovascular diseases radically and thereby of heart failure. Heart failure gene therapy refers to a therapeutic system of targeted drug delivery to the heart that uses fo...

journal_title：Circulation research

authors： Pleger ST,Brinks H,Ritterhoff J,Raake P,Koch WJ,Katus HA,Most P

更新日期：2013-08-30 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) expression is upregulated by hypoxia-inducible factor-1 (HIF-1) in ischemic tissues and growing tumors. Normally, HIF-1 activity depends on the amount of HIF-1alpha subunit, which is tightly regulated by the oxygen tension. In the myocardium, VEGF expression has been shown to ...

journal_title：Circulation research

authors： Kim CH,Cho YS,Chun YS,Park JW,Kim MS

更新日期：2002-02-08 00:00:00

abstract：:Phospholamban is a key regulatory protein that defines diastolic function. Proinflammatory cytokines interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) can depress contractility and intracellular Ca2+ currents and transients. An alteration in phospholamban expression is a possible pathway by wh...

journal_title：Circulation research

authors： McTiernan CF,Lemster BH,Frye C,Brooks S,Combes A,Feldman AM

更新日期：1997-10-01 00:00:00

abstract：:Vasoactive drugs are known to affect impedance (pressure/flow) and vessel wall motion in arteries. The nonlinear theory of oscillatory flow in straight elastic vessels indicates that wall shear rate is affected by changes in impedance phase angle and wall motion. To test whether wall shear rate depends on impedance ph...

journal_title：Circulation research

authors： White KC,Kavanaugh JF,Wang DM,Tarbell JM

更新日期：1994-10-01 00:00:00

abstract：:The hypothesis that neurally mediated coronary vasodilation occurs as part of the carotid baroreceptor reflex was investigated. The left main coronary artery was cannulated and perfused at constant pressure (100 mm Hg) in closed-chest, chloralose-anesthetized dogs. The heart was paced at a constant rate between 60 and...

journal_title：Circulation research

authors： Ito BR,Feigl EO

更新日期：1985-04-01 00:00:00

abstract：:We examined the role of endogenous NO in the autonomic regulation of atrioventricular (AV) nodal function by studying spontaneous action potentials (SAPs) and L-type Ca2+ current (ICa-L) in isolated single AV nodal cells from adult rabbit hearts. Both the perforated and the membrane-ruptured patch-clamp techniques in ...

journal_title：Circulation research

authors： Han X,Kobzik L,Balligand JL,Kelly RA,Smith TW

更新日期：1996-06-01 00:00:00

abstract：:Effects of concentrations of intracellular calcium, [Ca2+]i, on the voltage-dependent Ca2+ current (ICa) recorded from dispersed single smooth muscle cells of the rabbit portal vein were studied, using a whole cell voltage clamp method combined with an intracellular perfusion technique. Outward currents were minimized...

journal_title：Circulation research

authors： Ohya Y,Kitamura K,Kuriyama H

更新日期：1988-02-01 00:00:00

abstract：RATIONALE:Allogeneic mesenchymal precursor cells (MPCs) have been effective in large animal models of ischemic and nonischemic heart failure (HF). OBJECTIVE:To evaluate the feasibility and safety of 3 doses (25, 75, or 150 million cells) of immunoselected allogeneic MPCs in chronic HF patients in a phase 2 trial. MET...

journal_title：Circulation research

authors： Perin EC,Borow KM,Silva GV,DeMaria AN,Marroquin OC,Huang PP,Traverse JH,Krum H,Skerrett D,Zheng Y,Willerson JT,Itescu S,Henry TD

更新日期：2015-08-28 00:00:00

abstract：RATIONALE:Lipoprotein(a) [Lp(a)] is a highly atherogenic low-density lipoprotein-like particle characterized by the presence of apoprotein(a) [apo(a)] bound to apolipoprotein B. Proprotein convertase subtilisin/kexin type 9 (PCSK9) selectively binds low-density lipoprotein; we hypothesized that it can also be associate...

journal_title：Circulation research

authors： Tavori H,Christian D,Minnier J,Plubell D,Shapiro MD,Yeang C,Giunzioni I,Croyal M,Duell PB,Lambert G,Tsimikas S,Fazio S

更新日期：2016-06-24 00:00:00

abstract：:Although peroxisome proliferator-activated receptor gamma (PPARgamma) ligands have an antihypertensive effect in vivo, the precise mechanism has not been fully elucidated. We examined their effects on Rho/Rho kinase pathway, a key regulator of vascular tone. In cultured rat aortic smooth muscle cells (RASMC), Rho kina...

journal_title：Circulation research

authors： Wakino S,Hayashi K,Kanda T,Tatematsu S,Homma K,Yoshioka K,Takamatsu I,Saruta T

更新日期：2004-09-03 00:00:00

abstract：:We recently showed that the transient expression of a hemagglutinin (HA) epitope-tagged, constitutively active mutant of the G protein alpha(q) subunit (HAalpha(q)*) in the hearts of transgenic mice is sufficient to induce cardiac hypertrophy and dilatation that continue to progress after HAalpha(q)* protein becomes u...

journal_title：Circulation research

authors： Mende U,Kagen A,Meister M,Neer EJ

更新日期：1999-11-26 00:00:00

abstract：:3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) can exert beneficial effects independently of serum cholesterol reduction by increasing the bioavailability of nitric oxide. However, it is unclear whether statins can exert such effects directly on cardiac myocytes and whether mitochondria...

journal_title：Circulation research

authors： Jones SP,Teshima Y,Akao M,Marbán E

更新日期：2003-10-17 00:00:00

abstract：:Bradykinin relaxes arterioles on the brain's surface. This response is endothelium-dependent. The data presented here confirm the hypothesis that hydroxyl free radical mediates this response and may be the endothelium-dependent relaxing factor for bradykinin in this microvascular bed. The response to a locally applied...

journal_title：Circulation research

authors： Rosenblum WI

更新日期：1987-10-01 00:00:00

abstract：RATIONALE:7-Ketocholesterol (7-KC), a form of cholesterol oxidation product, plays an essential role in the atherogenesis in animal models. OBJECTIVE:We sought to determine the association of circulating 7-KC with clinical cardiovascular outcomes and total mortality in patients with stable coronary artery disease. ME...

journal_title：Circulation research

authors： Song J,Wang D,Chen H,Huang X,Zhong Y,Jiang N,Chen C,Xia M

更新日期：2017-05-12 00:00:00

abstract：:Epidermal fatty acid-binding protein (E-FABP), previously characterized in human keratinocytes, is a cytoplasmic protein of 15 kD that specifically binds fatty acids (FAs). Previous PAGE-immunoblotting studies indicated that several human tissues display an immunoreactive band with an electrophoretic mobility identica...

journal_title：Circulation research

authors： Masouyé I,Hagens G,Van Kuppevelt TH,Madsen P,Saurat JH,Veerkamp JH,Pepper MS,Siegenthaler G

更新日期：1997-09-01 00:00:00

abstract：RATIONALE:The recent discovery of meningeal lymphatics in mammals is reshaping our understanding of fluid homeostasis and cellular waste management in the brain, but visualization and experimental analysis of these vessels is challenging in mammals. Although the optical clarity and experimental advantages of zebrafish ...

journal_title：Circulation research

authors： Castranova D,Samasa B,Venero Galanternik M,Jung HM,Pham VN,Weinstein BM

更新日期：2021-01-08 00:00:00

abstract：:Thrombin stimulates synthesis and secretion of endothelin-1 (ET-1), a vasoactive peptide that triggers responses in the vascular endothelium and smooth muscle. We investigated the signal transduction pathways by which thrombin stimulates preproET-1 gene expression and ET-1 peptide secretion in macrovascular cells (hum...

journal_title：Circulation research

authors： Marsen TA,Simonson MS,Dunn MJ

更新日期：1995-06-01 00:00:00

abstract：:Abnormal mechanical forces can trigger aberrant proliferation of endothelial and smooth muscle cells, as observed in the progression of vascular diseases such as atherosclerosis. It has been previously shown that cells can sense physical forces such as stretch through adhesions to the extracellular matrix. Here, we se...

journal_title：Circulation research

authors： Liu WF,Nelson CM,Tan JL,Chen CS

更新日期：2007-08-31 00:00:00

abstract：:The present study was undertaken to determine the mechanism of neointima formation in rabbit arteries subjected to extensive endothelial desquamation. Endothelial cells were selectively removed from the abdominal aorta by passing an inflated balloon catheter through the vessel. The healing response was then studied se...

journal_title：Circulation research

authors： Spaet TH,Stemerman MB,Veith FJ,Lejnieks I

更新日期：1975-01-01 00:00:00

abstract：:Leptin, a protein encoded by the obese gene, is produced by adipocytes and released into the bloodstream. In obese humans, serum leptin levels are increased and correlate with the individual's body mass index and blood pressure. Elevated serum concentrations of endothelin-1 (ET-1), a potent vasoconstrictor and mitogen...

journal_title：Circulation research

authors： Quehenberger P,Exner M,Sunder-Plassmann R,Ruzicka K,Bieglmayer C,Endler G,Muellner C,Speiser W,Wagner O

更新日期：2002-04-05 00:00:00

abstract：:Despite improvements in the therapy of underlying heart disease, sudden cardiac death is a major cause of death worldwide. Disturbed Na and Ca handling is known to be a major predisposing factor for life-threatening tachyarrhythmias. In cardiomyocytes, many ion channels and transporters, including voltage-gated Na and...

journal_title：Circulation research

authors： Wagner S,Maier LS,Bers DM

更新日期：2015-06-05 00:00:00

abstract：:The mechanism of propranolol-inhibited sarcolemmal membrane lipid peroxidation was investigated by electron spin resonance spin-trapping technique using 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) and 2-methyl-2-nitrosopropane (MNP). Highly purified canine myocytic sarcolemma were peroxidized by a superoxide-driven (from ...

journal_title：Circulation research

authors： Mak IT,Arroyo CM,Weglicki WB

更新日期：1989-10-01 00:00:00

abstract：:Alternans in heart is important as pulsus alternans in cardiac failure and electrophysiological alternans in myocardial ischemia. The explanation of this phenomenon is still unclear. We attempted to investigate the cellular mechanisms of alternans by measuring intracellular free calcium concentration [( Ca2+]i) with t...

journal_title：Circulation research

authors： Lab MJ,Lee JA

更新日期：1990-03-01 00:00:00

abstract：RATIONALE:Senescence of pulmonary artery smooth muscle cells (PA-SMCs) caused by telomere shortening or oxidative stress may contribute to pulmonary hypertension associated with chronic lung diseases. OBJECTIVE:To investigate whether cell senescence contributes to pulmonary vessel remodeling and pulmonary hypertension...

journal_title：Circulation research

authors： Noureddine H,Gary-Bobo G,Alifano M,Marcos E,Saker M,Vienney N,Amsellem V,Maitre B,Chaouat A,Chouaid C,Dubois-Rande JL,Damotte D,Adnot S

更新日期：2011-08-19 00:00:00

abstract：:The introduction of statins ≈ 30 years ago ushered in the era of lipid lowering as the most effective way to reduce risk of atherosclerotic cardiovascular disease. Nonetheless, residual risk remains high, and statin intolerance is frequently encountered in clinical practice. After a long dry period, the field of thera...

journal_title：Circulation research

authors： Shapiro MD,Fazio S

更新日期：2016-02-19 00:00:00

abstract：:The cardiac high molecular weight proteins/ryanodine receptors were purified to homogeneity from junctional sarcoplasmic reticulum membranes and shown to exhibit large conductance calcium channel activity. High molecular weight proteins were solubilized from junctional sarcoplasmic reticulum in zwitterionic detergent ...

journal_title：Circulation research

authors： Rardon DP,Cefali DC,Mitchell RD,Seiler SM,Jones LR

更新日期：1989-04-01 00:00:00

abstract：RATIONALE:In ventricular myocytes of large mammals with low T-tubule density, a significant number of ryanodine receptors (RyRs) are not coupled to the sarcolemma; cardiac remodeling increases noncoupled RyRs. OBJECTIVE:Our aim was to test the hypothesis that coupled and noncoupled RyRs have distinct microdomain-depen...

journal_title：Circulation research

authors： Dries E,Bito V,Lenaerts I,Antoons G,Sipido KR,Macquaide N

更新日期：2013-11-08 00:00:00

abstract：:Cardiac alpha-adrenergic receptors mediate cellular responses to norepinephrine through an undefined series of molecular events. We examined the possibility that phosphoinositide hydrolysis was stimulated through alpha-adrenergic receptors in cardiomyocytes purified from adult rat ventricle. Phosphoinositide stores we...

journal_title：Circulation research

authors： Brown JH,Buxton IL,Brunton LL

更新日期：1985-10-01 00:00:00

abstract：:In adult mammals, massive sudden loss of cardiomyocytes after infarction overwhelms the limited regenerative capacity of the myocardium, resulting in the formation of a collagen-based scar. Necrotic cells release danger signals, activating innate immune pathways and triggering an intense inflammatory response. Stimula...

journal_title：Circulation research

authors： Prabhu SD,Frangogiannis NG

更新日期：2016-06-24 00:00:00