当前位置： SCI文献检索 > AMERICAN HEART JOURNAL期刊下所有文献 > A randomized, placebo-controlled trial of early eptifibatide for non-ST-segment elevation acute coronary syndromes.

A randomized, placebo-controlled trial of early eptifibatide for non-ST-segment elevation acute coronary syndromes.

Abstract：

BACKGROUND:The acute benefits of platelet glycoprotein IIb/IIIa inhibitors for non-ST-segment elevation acute coronary syndromes (NSTE ACS) remain unclear. METHODS:In this pilot trial, 311 patients with NSTE ACS were randomly assigned in the emergency department to double-blinded therapy with eptifibatide or placebo for 12 to 24 hours before crossover to open-label eptifibatide. Serial creatine-kinase MB (CK-MB) and quantitative cardiac troponin T levels were collected during the first 24 hours to assess the impact of early platelet glycoprotein IIb/IIIa blockade on infarct size as measured by cardiac markers. RESULTS:Median peak CK-MB (10.3 vs 11.8 ng/mL; P =.71) and peak quantitative cardiac troponin T levels (0.2 vs 0.3 ng/mL; P =.95) were similar between treatment groups, respectively. Median calculated peak CK-MB values (41 vs 40 ng/mL; P =.72) and area under the CK-MB curve measurements (980 vs 764 microg/min/L; P =.68) from curve-fitting analyses that could be performed in 106 of 311 patients were also similar. CONCLUSIONS:In this pilot trial, early administration of eptifibatide in the emergency department did not modulate serologic measurements of infarct size in patients with NSTE ACS.

journal_name

Am Heart J

journal_title

American heart journal

authors

Roe MT,Christenson RH,Ohman EM,Bahr R,Fesmire FM,Storrow A,Mollod M,Peacock WF,Rosenblatt JA,Yang H,Fraulo ES,Hoekstra JW,Gibler WB,EARLY Investigators.,Emergency Medicine Cardiac Research and Education Group.

doi

10.1016/S0002-8703(03)00517-9

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

993-8

issue

6

eissn

0002-8703

issn

1097-6744

pii

S0002870303005179

journal_volume

146

pub_type

临床试验,杂志文章,随机对照试验

相关文献

AMERICAN HEART JOURNAL文献大全
  • Hemodynamic, electrocardiographic, and metabolic effects of fructose diphosphate on acute myocardial ischemia.

    abstract：:The hemodynamic, electrocardiographic, and metabolic responses of dogs with acute myocardial ischemia to intravenous administration of fructose-1,6-diphosphate (FDP) were assessed. Analysis of the results (compared to dextrose control) revealed evidence of major improvement of LVEDP and cardiac output, significant dec...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(80)90228-8

    authors： Markov AK,Oglethorpe NC,Blake TM,Lehan PH,Hellems HK

    更新日期：1980-11-01 00:00:00

  • Adaptation to myocardial ischemia during repeated dynamic exercise in relation to findings at cardiac catheterization.

    abstract：:It has been suggested that the myocardium is able to recruit endogenous protective mechanisms in response to repeated ischemia and reperfusion. We set out to study whether this is manifested in patients with coronary artery disease in the form of fewer signs of myocardial ischemia during the second of two successive e...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(96)90272-0

    authors： Ylitalo K,Jama L,Raatikainen P,Peuhkurinen K

    更新日期：1996-04-01 00:00:00

  • Identification of the ischemic etiology of heart failure by cardiovascular magnetic resonance imaging: diagnostic accuracy of late gadolinium enhancement.

    abstract：BACKGROUND:A large proportion of patients with heart failure (HF) have a large and poorly contracting left ventricle. The noninvasive recognition of the ischemic etiology of such patients is difficult, and for this purpose, usually patients undergo coronary angiography. It has been shown that cardiovascular magnetic re...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2005.03.068

    authors： Casolo G,Minneci S,Manta R,Sulla A,Del Meglio J,Rega L,Gensini G

    更新日期：2006-01-01 00:00:00

  • Tachyarrhythmias associated with programmable automatic atrial antitachycardia pacemakers.

    abstract：:A multiprogrammable automatic antitachycardia pacemaker (Cybertach-60), connected to a tined "J" wire electrode, was positioned in the right atrial appendage in three patients with recurrent supraventricular tachycardia (SVT). Mechanisms of SVT included atrioventricular (AV) nodal reentry (two patients) and reciprocat...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(83)90648-8

    authors： Lerman BB,Waxman HL,Buxton AE,Sweeney M,Josephson ME

    更新日期：1983-11-01 00:00:00

  • The prognostic value of the changes in the mode of ventricular tachycardia induction noted during therapy with a marked reduction of ventricular ectopic activity.

    abstract：:The prognostic significance of changes in the mode of induction of ventricular tachycardia (VT) noted during therapy was studied in 49 patients with sustained VT or ventricular fibrillation. Before treatment, all patients had inducible sustained VT by programmed stimulation (one to three extrastimuli) and frequent (gr...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(87)90189-x

    authors： Kim SG,Felder SD,Seiden SW,Waspe LE,Fisher JD

    更新日期：1987-11-01 00:00:00

  • Propranolol therapy alters estimation of potential cardiovascular risk derived from submaximal postinfarction exercise testing.

    abstract：:We studied the effect of propranolol administration on risk assessment based on submaximal exercise testing performed early after myocardial infarction. A total of 70 patients with recent infarction underwent modified Bruce treadmill testing with simultaneous measurement of expired gases in the absence of antianginal ...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0002-8703(91)90009-7

    authors： Curtis JL,Houghton JL,Patterson JH,Koch G,Bradley DA,Adams KF Jr

    更新日期：1991-06-01 00:00:00

  • Hemodynamic evaluation of the Ionescu-Shiley pericardial xenograft in the mitral position.

    abstract：:Hemodynamic studies were performed in 27 patients at a mean interval of 40.3 (range 24 to 59) months following mitral valve replacement with pericardial xenografts. Six patients had sequential studies, one before operation and two separate investigations at mean intervals of 11.2 and 42.8 months following valve replac...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(78)90301-0

    authors： Tandon AP,Smith DR,Ionescu MI

    更新日期：1978-05-01 00:00:00

  • Long-term outcomes of arrhythmia and distinct electrophysiological features in congenitally corrected transposition of the great arteries in an Asian cohort.

    abstract：:Congenitally corrected transposition of the great arteries (ccTGA) is associated with various types of arrhythmia, including supraventricular tachycardia (SVT) and complete atrioventricular block (cAVB). Our study aims to characterize the arrhythmia burden, associated risk factors, arrhythmia mechanisms, and the long-...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2020.10.057

    authors： Tseng WC,Huang CN,Chiu SN,Lu CW,Wang JK,Lin MT,Chen CA,Wu MH

    更新日期：2021-01-01 00:00:00

  • Evaluation of plasma natriuretic peptides as markers for left ventricular dysfunction.

    abstract：:To test the hypothesis that elevated plasma levels of natriuretic peptides may serve to identify patients with left ventricular (LV) dysfunction, we assessed the predictive diagnostic value of natriuretic peptide levels, in addition to clinical and electro-cardiographic risk factors, as noninvasive indicators of cardi...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(97)70079-6

    authors： Muders F,Kromer EP,Griese DP,Pfeifer M,Hense HW,Riegger GA,Elsner D

    更新日期：1997-09-01 00:00:00

  • Impact of cardioversion strategy on functional capacity in patients with atrial fibrillation: the Assessment of Cardioversion Using Transesophageal Echocardiography (ACUTE) study.

    abstract：BACKGROUND:The ACUTE Trial studied a transesophageal echocardiography (TEE)-guided strategy compared with a conventional strategy for management of patients with atrial fibrillation undergoing direct current cardioversion. The primary aim was to determine if patient functional capacity, measured by the Duke Activity St...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2004.08.014

    authors： Jasper SE,Lieber EA,Murray RD,Apperson-Hansen C,Black IW,Grimm RA,Pape LA,Klein AL,ACUTE Investigators.

    更新日期：2005-02-01 00:00:00

  • Risk factors and noncontraceptive estrogen use in women with and without coronary disease.

    abstract：:To evaluate the risk factors for coronary disease, 345 women, aged 35 to 59 years, who had undergone coronary arteriography for suspected coronary disease completed a mail questionnaire, telephone interview, or both. Two hundred eight women with angiographically normal coronary arteries constituted the control group, ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(89)90398-0

    authors： McFarland KF,Boniface ME,Hornung CA,Earnhardt W,Humphries JO

    更新日期：1989-06-01 00:00:00

  • Training cardiovascular outcomes researchers: A survey of mentees and mentors to identify critical training gaps and needs.

    abstract：BACKGROUND:Many young investigators are interested in cardiovascular (CV) outcomes research; however, the current training experience of early investigators across the United States is uncertain. METHODS:From April to November 2014, we surveyed mentees and mentors of early-stage CV outcomes investigators across the Un...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2017.07.022

    authors： Khazanie P,Al-Khatib SM,Wang TY,Crowley MJ,Kressin NR,Krumholz HM,Kiefe CI,Wells BL,O'Brien SM,Peterson ED,Sanders GD

    更新日期：2018-02-01 00:00:00

  • Pathobiology of atherosclerosis and plaque complications.

    abstract：:To understand the process of atherosclerosis, the homeostatic and protective functions of the endothelium must be considered. The endothelium serves as the interface between blood flow and the vascular tissues. It normally regulates vascular tone and structure through the release of vasoactive substances and maintenan...

    journal_title：American heart journal

    pub_type： 杂志文章,评审

    doi：10.1016/0002-8703(94)90251-8

    authors： Dzau VJ

    更新日期：1994-12-01 00:00:00

  • Arrhythmia inducibility and ventricular vulnerability in a chronic feline infarction model.

    abstract：:Ventricular tachyarrhythmias are the cause of sudden cardiac death in ischemic heart disease. Reliable animal models are necessary to study techniques for identifying individuals at risk and to develop effective modes of therapy. The purpose of the present study was to evaluate the inducibility of ventricular tachyarr...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(85)90191-7

    authors： Wetstein L,Mark R,Kelliher GJ,Friehling T,O'Connor KM,Kowey PR

    更新日期：1985-11-01 00:00:00

  • Usefulness of magnetic resonance imaging for evaluating great-vessel anatomy after arterial switch operation for D-transposition of the great arteries.

    abstract：:Magnetic resonance imaging (MRI) produces high-resolution images of great-vessel anatomy in pediatric patients. In this study seven patients, aged 6 to 27 months were evaluated by using gated MRI and two-dimensional echocardiography 4 to 26 months after arterial switch operation for D-transposition of the great arteri...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(94)90486-3

    authors： Hardy CE,Helton GJ,Kondo C,Higgins SS,Young NJ,Higgins CB

    更新日期：1994-08-01 00:00:00

  • The relationship between gender and clinical management after exercise stress testing.

    abstract：BACKGROUND:Controversy remains regarding whether gender differences exist in clinical management after exercise treadmill testing (ETT). METHODS:We studied 7,506 patients (49.8% women) without documented coronary heart disease referred for ETT from July 2001 to June 2004 in a community-based setting. We assessed the r...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2008.03.022

    authors： Daugherty SL,Peterson PN,Magid DJ,Ho PM,Bondy J,Hokanson JE,Ross CA,Rumsfeld JS,Masoudi FA

    更新日期：2008-08-01 00:00:00

  • Factors associated with development of atrial septal restriction in patients with tricuspid atresia involving the right-sided atrioventricular valve.

    abstract：BACKGROUND:Clinical practice is discrepant regarding routine enlargement of the interatrial communication (IAC) in patients with right-sided atrioventricular valve atresia. We determined the percentage and risk factors of those who develop a restrictive IAC. METHODS:Medical records were reviewed for patients treated f...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2007.07.037

    authors： Tzifa A,Gauvreau K,Geggel RL

    更新日期：2007-12-01 00:00:00

  • Can the same edge-detection algorithm be applied to on-line and off-line analysis systems? Validation of a new cinefilm-based geometric coronary measurement software.

    abstract：:In the Cardiovascular Measurement System (CMS) the edge-detection algorithm, which was primarily designed for the Philips digital cardiac imaging system (DCI), is applied to cinefilms. Comparative validation of CMS and DCI was performed in vitro and in vivo with intracoronary insertion of stenosis phantoms in anesthet...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(93)91045-g

    authors： Haase J,van der Linden MM,Di Mario C,van der Giessen WJ,Foley DP,Serruys PW

    更新日期：1993-08-01 00:00:00

  • Oxidative stress is related to exercise intolerance in patients with heart failure.

    abstract：:To assess the role of oxidative stress in exercise intolerance in patients with heart failure, a symptom-limited exercise test was performed with a bicycle ergometer in 12 patients with heart failure and in 7 members of a healthy control group. Level of plasma malondialdehyde, a marker of lipid peroxidation, at rest w...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(98)70351-5

    authors： Nishiyama Y,Ikeda H,Haramaki N,Yoshida N,Imaizumi T

    更新日期：1998-01-01 00:00:00

  • Impairment of cardiac autonomic function in patients with Duchenne muscular dystrophy: relationship to myocardial and respiratory function.

    abstract：BACKGROUND:Previous studies reported an impairment of nervous autonomic activity in patients with Duchenne muscular dystrophy (DMD). However, the relationship of the autonomic dysfunction to the impairment of cardiac mechanical function and of respiratory failure is not completely understood. METHODS:We evaluated card...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1067/mhj.2001.114804

    authors： Lanza GA,Dello Russo A,Giglio V,De Luca L,Messano L,Santini C,Ricci E,Damiani A,Fumagalli G,De Martino G,Mangiola F,Bellocci F

    更新日期：2001-05-01 00:00:00

  • Atrial septal aneurysms in infants and children.

    abstract：:Interatrial septal aneurysm (IASA) has been detected with increasing frequency since the advent of two-dimensional echocardiography (2DE). In this study, we investigated the prevalence, characteristics, and predisposing factors in IASA formation in 724 infants, children, and adolescents undergoing 2DE. Among this grou...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(87)90927-6

    authors： Wolf WJ,Casta A,Sapire DW

    更新日期：1987-05-01 00:00:00

  • Relation between cardiac troponin I and mortality in acute decompensated heart failure.

    abstract：BACKGROUND:Troponin level elevations are common in patients with acute decompensated heart failure (ADHF), yet their prognostic value above and beyond traditional predictors of outcomes in heart failure is uncertain. METHODS:In the EFFECT study, we determined the association between cardiac troponin I and all-cause mo...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2007.01.027

    authors： You JJ,Austin PC,Alter DA,Ko DT,Tu JV

    更新日期：2007-04-01 00:00:00

  • Pathophysiologic mechanisms underlying dobutamine- and exercise-induced wall motion abnormalities.

    abstract：BACKGROUND:Dobutamine and exercise echocardiography are accepted as tests of comparable efficacy for the diagnosis of coronary artery disease. Although dobutamine has been classified as "exercise simulating," the mechanisms of ischemia with dobutamine and exercise have not been well studied. This study sought to compar...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(98)70183-8

    authors： Mairesse GH,Vanoverschelde JL,Robert A,Climov D,Detry JM,Marwick TH

    更新日期：1998-07-01 00:00:00

  • Long-term outcome of unsuccessful percutaneous transluminal coronary angioplasty.

    abstract：:We analyzed the long-term outcome of 198 patients after unsuccessful percutaneous transluminal coronary angioplasty. Forty-nine percent underwent emergency coronary artery bypass grafting surgery, 17% had elective bypass surgery, and 34% were treated medically. The in-hospital mortality rate was 4%, and myocardial inf...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(05)80313-8

    authors： Tuzcu M,Simpfendorfer C,Dorosti K,Franco I,Golding L,Hollman J,Whitlow P

    更新日期：1990-04-01 00:00:00

  • A randomized controlled trial of low-dose hormone therapy on myocardial ischemia in postmenopausal women with no obstructive coronary artery disease: results from the National Institutes of Health/National Heart, Lung, and Blood Institute-sponsored Women'

    abstract：BACKGROUND:Compared with men, women have more evidence of myocardial ischemia with no obstructive coronary artery disease. Although low endogenous estrogen levels are associated with endothelial dysfunction, the role of low-dose hormone therapy has not been fully evaluated. We postulate that a 12-week duration of low-d...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ahj.2010.03.024

    authors： Merz CN,Olson MB,McClure C,Yang YC,Symons J,Sopko G,Kelsey SF,Handberg E,Johnson BD,Cooper-DeHoff RM,Sharaf B,Rogers WJ,Pepine CJ

    更新日期：2010-06-01 00:00:00

  • Bleeding and outcome in acute coronary syndrome: insights from continuous electrocardiogram monitoring in the Integrilin and Enoxaparin Randomized Assessment of Acute Coronary Syndrome Treatment (INTERACT) Trial.

    abstract：BACKGROUND:Bleeding is associated with adverse outcome in acute coronary syndromes. However, the precise pathophysiologic mechanisms have not been elucidated. We sought to determine the relationship between bleeding and myocardial ischemia detected by concurrent continuous electrocardiogram (ECG) monitoring and their i...

    journal_title：American heart journal

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ahj.2008.05.022

    authors： Yan AT,Yan RT,Huynh T,DeYoung P,Weeks A,Fitchett DH,Langer A,Goodman SG,INTERACT Investigators.

    更新日期：2008-10-01 00:00:00

  • Conduction disturbances of the bundle branches produced by lesions in the nonbranching portion of His bundle.

    abstract：:The present experiments were conducted on isolated dog hearts to demonstrate that conduction disturbances can be induced in the bundle branches by transection of about 50 per cent of the cross-sectional area of the His bundle on the right or left side. The His bundle, the posterior and anterior divisions of left bundl...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(76)80117-2

    authors： Fabregas RA,Tse WW,Han J

    更新日期：1976-09-01 00:00:00

  • Improved internal defibrillation efficacy with a biphasic waveform.

    abstract：:Clinically available automatic implantable defibrillators use a monophasic truncated exponential waveform shock; after delivery the charge remaining on the device's capacitors is "dumped" internally and wasted. The efficacy of a monophasic and biphasic truncated exponential defibrillation waveform produced by a single...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(89)90779-5

    authors： Fain ES,Sweeney MB,Franz MR

    更新日期：1989-02-01 00:00:00

  • Revival of transcatheter PFO closure: A meta-analysis of randomized controlled trials - impact of shunt size and age.

    abstract：BACKGROUND:Transcatheter foramen ovale closure (TPC) has emerged as a potential treatment option for patients with cryptogenic strokes and persistent foramen ovale (PFO). However, previous randomized controlled trials could hardly demonstrate any benefit compared to medical treatment (Med-Tx). Recently new data have be...

    journal_title：American heart journal

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.ahj.2018.03.025

    authors： Reinthaler M,Ozga AK,Sinning D,Curio J,Al-Hindwan HS,Bäckemo Johansson J,Jung F,Lendlein A,Rauch G,Landmesser U

    更新日期：2018-07-01 00:00:00

  • Vitamin D deficiency and coronary artery disease: a review of the evidence.

    abstract：:Coronary artery disease remains the leading cause of death in developed countries despite significant progress in primary prevention and treatment strategies. Older patients are at particularly high risk of poor outcomes following acute coronary syndrome and impaired nutrition, including low vitamin D levels, may play...

    journal_title：American heart journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.ahj.2013.11.012

    authors： Kunadian V,Ford GA,Bawamia B,Qiu W,Manson JE

    更新日期：2014-03-01 00:00:00