Abstract:
:Myeloperoxidase (MPO) catalyses the formation of hypochlorous acid and is involved in many (patho)physiological processes. The present study was designed to determine the effect of two MPO promoter polymorphisms (463G/A and 129G/A) on enzyme activity. In 243 healthy controls, genotypes were determined and MPO activity was measured on a single-cell level using a haematological analyser. The 129G/A polymorphism reduces MPO activity in neutrophils, whereas for the 463G/A polymorphism, only gender-dependent differences in MPO activity in older age groups could be found. When studying these polymorphisms in disease, therefore, age and gender should be included in the analysis.
journal_name
Br J Haematoljournal_title
British journal of haematologyauthors
Rutgers A,Heeringa P,Giesen JE,Theunissen RT,Jacobs H,Tervaert JWdoi
10.1046/j.1365-2141.2003.04602.xsubject
Has Abstractpub_date
2003-11-01 00:00:00pages
536-8issue
3eissn
0007-1048issn
1365-2141pii
4602journal_volume
123pub_type
杂志文章abstract::β- thalassaemia is a disorder of globin gene synthesis resulting in reduced or absent production of the β-globin chain in red blood cells. In this study, haematopoietic stem cells were isolated from the peripheral blood of six transfusion dependent β-thalassaemia patients and six healthy controls. Following 7 and 14 d...
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journal_title:British journal of haematology
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journal_title:British journal of haematology
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journal_title:British journal of haematology
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