Abstract：
:Reactive oxygen species are produced during exercise. The antioxidants prevent or limit tissue damages by these species in physiological conditions. In particular, ascorbate and urate scavenge peroxynitrite, which can alter the function of many molecules, including the lecithin-cholesterol acyltransferase (LCAT) enzyme involved in reverse cholesterol transport. The aims of the present study were to compare the plasma antioxidant response to an ergometric test (ET) in hypertensive and healthy subjects, evaluate the exercise-dependent nitrosative stress in plasma, and assess whether the LCAT activity is altered by the exercise. Plasma samples, prepared before and after ET from hypertensive or healthy volunteers, were analysed for their levels of ascorbate, urate, alpha-tocopherol, retinol, nitrotyrosine, and LCAT activity. The alpha-tocopherol and retinol levels did not significantly change in both groups during exercise, while the ascorbate level changed displaying higher increase in controls (+38.8%) than in hypertensives (+17.2%). In these patients, during ET, the urate and nitrotyrosine levels changed more than in normotensives (+13.5 and +40.6% vs -3.1 and +25.2%, respectively). The antioxidants effectively prevented loss or reduction of LCAT activity, as it was similar in hypertensives and normotensives, and did not change after ET. The results demonstrate that exercise is associated with enhanced protein nitrosation, and suggest that the ascorbate or urate levels increase to limit oxidative damage.
journal_name
J Hum Hypertensjournal_title
Journal of human hypertensionauthors
Santangelo L,Cigliano L,Montefusco A,Spagnuolo MS,Nigro G,Golino P,Abrescia Pdoi
10.1038/sj.jhh.1001617subject
Has Abstractpub_date
2003-11-01 00:00:00pages
791-8issue
11eissn
0950-9240issn
1476-5527pii
1001617journal_volume
17pub_type
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journal_title：Journal of human hypertension
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journal_title：Journal of human hypertension
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journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1995-05-01 00:00:00
abstract：:Adiponectin is a hormone involved in energy homeostasis by regulating glucose and lipid metabolism. In addition, the adiponectin gene (ADIPOQ) has polymorphisms that can modulate the circulating concentration of adiponectin. Abnormal adiponectin levels have been associated with pre-eclampsia (PE); however, the influen...
journal_title：Journal of human hypertension
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doi：10.1038/jhh.2013.53
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journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：
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journal_title：Journal of human hypertension
pub_type： 杂志文章
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1000726
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journal_title：Journal of human hypertension
pub_type： 杂志文章
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journal_title：Journal of human hypertension
pub_type： 杂志文章
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更新日期：2017-05-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1989-04-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/jhh.2014.99
更新日期：2015-08-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
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journal_title：Journal of human hypertension
pub_type： 杂志文章
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journal_title：Journal of human hypertension
pub_type： 杂志文章
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001484
更新日期：2002-11-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2015.58
更新日期：2016-03-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,多中心研究
doi：
更新日期：1995-07-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1000555
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
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pub_type： 杂志文章
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journal_title：Journal of human hypertension
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journal_title：Journal of human hypertension
pub_type： 杂志文章
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journal_title：Journal of human hypertension
pub_type： 杂志文章
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journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1990-12-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
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更新日期：2017-11-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
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