In vitro elution characteristics of commercially and noncommercially prepared antibiotic PMMA beads.

Abstract:

:The successful treatment of osteomyelitis with commercially prepared gentamicin-polymethylmethacrylate (PMMA) (Septopal) beads and surgical debridement has led to the use of this technique in the United States. However, commercially prepared gentamicin-PMMA beads are not currently available to orthopedic surgeons in the United States. Therefore, these surgeons commonly manufacture their own antibiotic-containing cement beads in the operating room at the time of surgery. There is little data that compare the antibiotic elution characteristics of such preparations to commercially prepared gentamicin-PMMA beads. This study compares the measured amount of antibiotic elution of either gentamicin or tobramycin from laboratory manufactured Zimmer, Simplex, or Palacos beads to commercially prepared gentamicin-PMMA (Septopal) beads. During a 30-day study period, commercially prepared gentamicin-PMMA beads eluted more total antibiotic and maintain higher concentrations than did antibiotic acrylic composites manufactured in the authors' laboratory.

journal_name

Clin Orthop Relat Res

authors

Nelson CL,Griffin FM,Harrison BH,Cooper RE

subject

Has Abstract

pub_date

1992-11-01 00:00:00

pages

303-9

issue

284

eissn

0009-921X

issn

1528-1132

pub_type

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