Pituitary adenoma proliferative indices and risk of recurrence.

Abstract:

:Twenty unselected pituitary adenomas have been examined for proliferative indices (PIs), and anterior pituitary hormone expression. All but two of the tumours were non-functional with proliferative indices from less than 0.1 to 0.5%. Two tumours were null cell adenomas with PIs less than 0.1 and 0.2%. The PIs of the three recurrent tumours was less than 1.0%. Gonadotrophin and TSH immunoreactivity was heterogenous and was found in 12/20 (60%) of the tumours. There was no significant relationship between PI, hormone expression or any other measured parameter. The biological behaviour of pituitary adenomas with a PI of less than 0.1% is uncertain, but those with a PI of greater than 0.1% are more likely to recur although longer follow-up is needed to confirm this.

journal_name

Br J Neurosurg

authors

Carboni P Jr,Detta A,Hitchcock ER,Postans R

doi

10.3109/02688699209002899

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

33-40

issue

1

eissn

0268-8697

issn

1360-046X

journal_volume

6

pub_type

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