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Midtrimester triple test levels in women with severe preeclampsia and HELLP syndrome.

Abstract：

BACKGROUND:The levels of midtrimester triple test constituents are known to be altered in hypertensive disorders of pregnancy. OBJECTIVE:Our aim was to determine whether midtrimester triple test constituent levels differ in women with severe preeclampsia and those who also develop HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome. METHODS:A retrospective chart analysis of 106 women with severe preeclampsia for whom midtrimester triple test data were available was made. None of these patients had fetuses with abnormal karyotype, nor did they deliver infants with malformations. The levels of midtrimester maternal serum alpha-fetoprotein (MSAFP), human chorionic gonadotropin (MShCG) and unconjugated estriol (MSuE3) of 74 patients with severe preeclampsia were compared with those of 32 patients who also developed HELLP syndrome. RESULTS:The mean MShCG was significantly higher and the mean MSuE3 was significantly lower in patients with HELLP syndrome than in those with only severe preeclampsia [1.78 multiple of the medians (MoM), standard error (SE) 0.18 vs. 1.27 MoM, SE 0.07, p=0.015 and 0.86 MoM, SE 0.05 vs. 1.04 MoM, SE 0.07; p = 0.03, respectively]. The two groups did not differ significantly with regard to MSAFP levels. CONCLUSION:Unexplained high levels of midtrimester MShCG and low levels of MSuE3 may be associated with the development of HELLP syndrome in women with severe preeclampsia.

journal_name

Acta Obstet Gynecol Scand

journal_title

Acta obstetricia et gynecologica Scandinavica

authors

Shenhav S,Gemer O,Volodarsky M,Zohav E,Segal S

doi

10.1034/j.1600-0412.2003.00250.x

subject

Has Abstract

pub_date

2003-10-01 00:00:00

pages

912-5

issue

10

eissn

0001-6349

issn

1600-0412

pii

250

journal_volume

82

pub_type

杂志文章

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