Effects of hormones on uPA, PAI-1 and suPAR from cultured endometrial and ovarian endometriotic stromal cells.

Abstract:

PROBLEM:To investigate whether endometriotic stromal cells release the urokinase plasminogen activator, soluble urokinase plasminogen activator receptor and plasminogen activator inhibitor-1. If so, to establish if there are any differences between endometrial stromal cells from women with and without endometriosis, and whether the release is hormonally regulated. METHOD:Biopsies were obtained from endometriotic tissue and from endometrium from women with and without endometriosis. Stromal cells were isolated, incubated and treated with estradiol-17beta, progesterone or raloxifen. Incubation media collected at 0, 24, 48 and 72 h were analyzed by enzyme-linked immunosorbent assay. RESULTS:All these types of stromal cells released the urokinase plasminogen activator, soluble urokinase plasminogen activator receptor and urokinase plasminogen inhibitor-1. There was a significantly higher release of urokinase plasminogen inhibitor-1 and lower release of urokinase plasminogen activator and soluble urokinase plasminogen activator receptor in endometriotic cells. The release of urokinase plasminogen activator from endometrial stromal cells decreased during the study period both in control cultures and in cultures treated with progesterone or estradiol-17beta, but not in cultures treated with raloxifen nor in endometriotic cultures. The given hormones did not influence the release of the soluble urokinase plasminogen activator receptor. Progesterone significantly increased the urokinase plasminogen inhibitor-1 release in endometrial cells from both patient categories, and raloxifen significantly reduced the urokinase plasminogen inhibitor-1 release from stromal cells from both tissue categories from endometriotic patients. Estradiol-17beta had no effect. CONCLUSIONS:This study shows that stromal cells from endometrium and endometriotic tissues release the urokinase plasminogen activator, soluble urokinase plasminogen activator receptor and urokinase plasminogen inhibitor-1. The release is partly hormonally regulated, but differently in endometriotic than in endometrial cells.

authors

Guan YM,Carlberg M,Bruse C,Carlström K,Bergqvist A

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

389-97

issue

5

eissn

0001-6349

issn

1600-0412

pii

aog810503

journal_volume

81

pub_type

杂志文章
  • A prospective randomized trial to compare immediate and 24-hour delayed catheter removal following total abdominal hysterectomy.

    abstract:OBJECTIVE:To assess whether early or immediate removal of a 12F in-dwelling Foley catheter after total abdominal hysterectomy affects the level of subjective pain assessment postoperatively. DESIGN:Randomized controlled trial. SETTING:University Hospital. POPULATION:Seventy women underwent total abdominal hysterecto...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1600-0412.2011.01104.x

    authors: Chai J,Pun TC

    更新日期:2011-05-01 00:00:00

  • Prospective counselling after prenatal diagnosis of fetal malformations: interventions and parental reactions.

    abstract::A model of prospective counselling and intervention after prenatal diagnosis of fetal malformation is presented. 13 patients/couples with severe malformations were fully counselled, 3 patients/couples interviewed post-termination. Objectives of the counselling strategy were to support patient autonomy, facilitate mour...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016348909028667

    authors: Langer M,Ringler M

    更新日期:1989-01-01 00:00:00

  • Repeated antenatal corticosteroid treatment: a systematic review and meta-analysis.

    abstract:OBJECTIVE:To systematically review the efficacy and safety of repeated antenatal corticosteroid on neonatal morbidity, growth and later development. DESIGN:MEDLINE, Cochrane database and a bibliography of identified articles were searched for English language studies. Design. Meta-analysis of randomized controlled tri...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/j.1600-0412.2011.01132.x

    authors: Peltoniemi OM,Kari MA,Hallman M

    更新日期:2011-07-01 00:00:00

  • Prolactin receptor in human endometriotic tissues.

    abstract:BACKGROUND:Augmented serum prolactin (PRL) levels have been implicated as a cause for infertility in patients with endometriosis. However, it has not been established whether this lactogenic hormone or its receptor (PRLR) have specific effects on the development of human endometriosis. In the present study we assessed ...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0412.2002.810102.x

    authors: Martinez LB,Leyva MZ,Romero IC

    更新日期:2002-01-01 00:00:00

  • Does group training during pregnancy prevent lumbopelvic pain? A randomized clinical trial.

    abstract:BACKGROUND:Prevention of lumbopelvic pain in pregnancy has been sparsely studied. One aim of this study was to assess if a 12-week training program during pregnancy can prevent and/or treat lumbopelvic pain. A randomized controlled trial was conducted at Trondheim University Hospital and three outpatient physiotherapy ...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/00016340601089651

    authors: Mørkved S,Salvesen KA,Schei B,Lydersen S,Bø K

    更新日期:2007-01-01 00:00:00

  • Elevated plasma levels of oxytocin in women taking low-dose oral contraceptives. Identification of the plasma oxytocin with high performance liquid chromatography.

    abstract::The aim of the present study was to investigate whether low-dose oral contraceptives affect oxytocin concentrations in plasma. Twenty women participated in an open cross-over study. Six consecutive blood samples were drawn twice, with a 4-week interval, in the luteal phase of the menstrual cycle when the women were/we...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.3109/00016348909087694

    authors: Stock S,Silber M,Uvnäs-Moberg K

    更新日期:1989-01-01 00:00:00

  • Is home-based pelvic floor muscle training effective in treatment of urinary incontinence after birth in primiparous women? A randomized controlled trial.

    abstract:OBJECTIVE:To assess the effect of pelvic floor muscle training (PFMT) on pelvic floor muscle strength and urinary incontinence (UI) in primiparous women who underwent a home training program between three and 9 months after delivery. DESIGN:Randomized controlled trial. POPULATION:One hundred primiparous women were co...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/aogs.12173

    authors: Ahlund S,Nordgren B,Wilander EL,Wiklund I,Fridén C

    更新日期:2013-08-01 00:00:00

  • Women's experiences and attitudes towards expectant management and induction of labor for post-term pregnancy.

    abstract:BACKGROUND:Clinical guidelines for post-term management differ, and studies on women's attitudes are lacking. We aimed to assess the experiences and attitudes among women managed with serial antenatal monitoring or induction of labor, and the effects of post-term pregnancy on self-reports of quality of life. METHODS:W...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/00016340701416929

    authors: Heimstad R,Romundstad PR,Hyett J,Mattsson LA,Salvesen KA

    更新日期:2007-01-01 00:00:00

  • Estimation of blood loss after cesarean section and vaginal delivery has low validity with a tendency to exaggeration.

    abstract:BACKGROUND:Excessive bleeding is one of the major threats to women at childbirth. The aim of this study was to validate estimation of blood loss during delivery. METHODS:Bleeding was estimated after 29 elective cesarean sections and 26 vaginal deliveries and compared to blood loss measured by extraction of hemoglobin ...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1080/00016340600985032

    authors: Larsson C,Saltvedt S,Wiklund I,Pahlen S,Andolf E

    更新日期:2006-01-01 00:00:00

  • Diagnostic accuracy of outpatient endocervical curettage using conventional and Vabra curettage of the cervix.

    abstract::With the object of examining the diagnostic accuracy of and pain reaction to endocervical curettage (ECC) either by using a new instrument, Vabra mc cervix, or with a conventional 3 mm metal curette, 298 patients with histologically verified cervical intraepithelial neoplasia (CIN) or cytological suspicion have been i...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00016348809004171

    authors: Hald F,Kristoffersen SE,Hairi J,Hansen MK

    更新日期:1988-01-01 00:00:00

  • Rupture of rudimentary horn pregnancy.

    abstract::A rare case of rupture of an noncommunicating rudimentary horn pregnancy is reported. The pregnancy proceeded to 25 gestational weeks, when the rudimentary horn ruptured. The patient had signs and symptoms of massive hemoperitoneum. An emergency exploratory laparotomy revealed rupture of the gravid rudimentary horn an...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016349209009926

    authors: Chang JC,Lin YC

    更新日期:1992-04-01 00:00:00

  • Amniotic fluid epidermal growth factor concentrations. The effect of intra-amniotic thyroxine for acceleration of fetal maturation.

    abstract::Intra-amniotic thyroxine (200-500 ug) was administered weekly to 29 women in the third trimester to enhance fetal maturation. Lecithin-sphingomyelin ratio (L/S) and epidermal growth factor (EGF) were measured in amniotic fluid (AF) before (n = 58) and after (n = 92) administration of thyroxine. The AF L/S ratio and EG...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016349309068033

    authors: Hofmann GE,Romaguera J,Williams RF,Adamsons K,Norfolk VA,San Juan PR

    更新日期:1993-05-01 00:00:00

  • Ovarian metastatic carcinoma presenting as a primary cervical carcinoma.

    abstract::A case of an ovarian carcinoma presenting as a primary cervical carcinoma is described. Although a rare event, this must be considered whenever the clinical or histological findings are unusual. The importance of careful histological review of all specimens in cases such as this is emphasized. ...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016349009028691

    authors: Danielian PJ

    更新日期:1990-01-01 00:00:00

  • Rupture of the uterus in labor. A review of 96 cases.

    abstract::Ninety-six cases of ruptured uterus in labor treated in the University Teaching Hospitals, Benghazi, Libya between 1977 and 1980 are reported. An incidence of 1 in 585 deliveries remained unchanged during the period of study. Twenty uterine ruptures occurred in a previously scarred uterus. Rupture of the unscarred ute...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016348509155137

    authors: Rahman J,Al-Sibai MH,Rahman MS

    更新日期:1985-01-01 00:00:00

  • A prospective study of women and girls undergoing fertility preservation due to oncologic and non-oncologic indications in Sweden-Trends in patients' choices and benefit of the chosen methods after long-term follow up.

    abstract:INTRODUCTION:In Scandinavian countries, programs for fertility preservation are offered free of charge at tertiary-care university hospitals to all patients facing treatments with risk of subsequent sterility. In this prospective study we aimed to investigate trends in female patients' choices after counseling and fert...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aogs.13559

    authors: Rodriguez-Wallberg KA,Marklund A,Lundberg F,Wikander I,Milenkovic M,Anastacio A,Sergouniotis F,Wånggren K,Ekengren J,Lind T,Borgström B

    更新日期:2019-05-01 00:00:00

  • A case of hepatocellular carcinoma in pregnancy detected by routine screening of maternal alpha-feto-protein.

    abstract::A rare case of hepatocellular carcinoma in a 31-year-old woman is reported. The diagnosis was made at 16 weeks of pregnancy when very high levels of alpha-feto-protein were found upon routine examination. The pregnancy was terminated and cytostatic therapy was given. The patient died one year later. ...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016349109006217

    authors: Goldberg I,Hod M,Katz I,Friedman S,Ovadia J

    更新日期:1991-01-01 00:00:00

  • Oral misoprostol vs. vaginal gemeprost prior to surgical termination of pregnancy in nulliparae.

    abstract:BACKGROUND:To compare the efficacy and side-effects of intravaginal gemeprost with those of oral misoprostol for cervical ripening prior to first-trimester pregnancy termination in nulliparous women. METHODS:Retrospective analysis of surgical terminations of pregnancy performed before 90 days of gestation. Intravagina...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.0001-6349.2004.00441.x

    authors: Celentano C,Prefumo F,Di Andrea O,Presti F,Di Nisio Q,Rotmensch S

    更新日期:2004-08-01 00:00:00

  • Treatment of vulvovaginal erosive and stenosing lichen planus by surgical dilatation and methotrexate.

    abstract::We treated five patients with stenosing lichen planus [LP] of the vulvovaginal region with methotrexate supplemented with ultrapotent corticosteroid cream and tacrolimus, in combination with surgical dilatation. All patients experienced long-term symptom relief, and there was only minimal or moderate re-stenosing of t...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1080/00016340601110721

    authors: Kortekangas-Savolainen O,Kiilholma P

    更新日期:2007-01-01 00:00:00

  • The performance of a simple scoring system screening for low birthweight infants for gestation in an unselected pregnant population.

    abstract::Identification of poor fetal growth is an important objective of antenatal care. We evaluated the validity of the Wennergren score to predict small for gestational age and/or underweight for length infants (low ponderal index). To 405 randomly chosen pregnant women from our university hospital population, this numeric...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016348909006141

    authors: Sijmons EA,Vervest HA,Kerkhof M,Reuwer PJ,Bruinse HW

    更新日期:1989-01-01 00:00:00

  • 11C-methionine kinetics in pregnant rhesus monkeys studied by positron emission tomography: a new approach to feto-maternal metabolism.

    abstract::By use of Positron Emission Tomography (PET), dynamic studies of the metabolism within the feto-maternal unit can be performed using various tracers. Many compounds like amino acids, carbohydrates, fatty acids and drugs can be performed using various tracers. Many compounds like amino acids, carbohydrates, fatty acids...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016348409155554

    authors: Berglund L,Halldin C,Lilja A,Lindberg BS,Lundqvist H,Långström B,Malmborg P,Någren K,Stålnacke CG

    更新日期:1984-01-01 00:00:00

  • Classification of cesarean sections among immigrants in Belgium.

    abstract:OBJECTIVE:To provide insight into the differential effect of immigration on cesarean section (CS) rates, using the Robson classification. DESIGN:A population-based study using birth certificates from the birth registry of 2009. SETTING:All births in two of the three Belgian regions excluding Flanders. POPULATION:37 ...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aogs.12003

    authors: Minsart AF,De Spiegelaere M,Englert Y,Buekens P

    更新日期:2013-02-01 00:00:00

  • INTRAMUSCULAR 15(S)15 METHYL PGF2α FOR PREOPERATIVE CERVICAL DILATATION DURING FIRST TRIMESTER.

    abstract::The effect of single intramuscular injection of 15(S)15 methyl PGF2α . (Prostin 15M, Upjohn) on cervical dilatation was tried in women during first trimester pregnancy. Prostin 15M was given at a dose of 250 µg. Three hours later the cervical dilatation and uterine consistency were assessed and recorded, prior to vacu...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aogs.1988.67.s145.55

    authors: Devi PK,Jain S,Cr K,Ks R

    更新日期:1988-01-01 00:00:00

  • Frequency of anal sphincter rupture at delivery in Sweden and Finland--result of difference in manual help to the baby's head.

    abstract:BACKGROUND:Anal sphincter rupture is a serious complication of vaginal delivery and almost half the affected women have persistent defecatory symptoms despite adequate primary repair. During the past decade, the incidence of anal sphincter ruptures has been increasing in Sweden and is currently estimated to occur in 2....

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:

    authors: Pirhonen JP,Grenman SE,Haadem K,Gudmundsson S,Lindqvist P,Siihola S,Erkkola RU,Marsal K

    更新日期:1998-11-01 00:00:00

  • Vaginal erotic sensitivity by sexological examination.

    abstract::We studied vaginal erotic sensitivity by vaginal sexological examinations as part of the evaluation and treatment process of couples complaining of female coital anorgasmia but readily orgasmic at female self--or partner-performed external genital stimulation. The existence on the anterior vaginal wall of an anatomica...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016348609161498

    authors: Hoch Z

    更新日期:1986-01-01 00:00:00

  • Pain evoked by distension of the uterine cervix in women with dysmenorrhea: evidence for central sensitization.

    abstract:OBJECTIVE:To study sensitization in women with dysmenorrhea using a standardized experimental model. Women with dysmenorrhea experience intense visceral pain during menstruation. The dysmenorrhea pain mechanisms are not known but sensitization may play a role. DESIGN:Prospective experimental study. SAMPLE:Ten women w...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1111/aogs.12403

    authors: Arendt-Nielsen L,Madsen H,Jarrell J,Gregersen H,Drewes AM

    更新日期:2014-08-01 00:00:00

  • Diclofenac pyrrolidine versus Ketoprofen for the relief of pain from episiotomy: a randomized controlled trial.

    abstract:BACKGROUND:The treatment of pain from episiotomy or from tearing of perineal tissues during childbirth is often unapplied, although discomfort may be severe. We performed a randomized double-blind controlled trial to compare the effectiveness and side-effects of two analgesics in the management of postpartum perineal p...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.0001-6349.2005.00758.x

    authors: Facchinetti F,Casini ML,Costabile L,Malavasi B,Unfer V

    更新日期:2005-10-01 00:00:00

  • Soluble fibrin in plasma as a sign of activated coagulation in patients with pregnancy complications.

    abstract:BACKGROUND:Disseminated intravascular coagulation (DIC) is a frequently observed complication in pregnant women. The laboratory diagnosis of DIC is difficult but the development in the detection of circulating soluble fibrin has improved the possibility. METHODS:A number of pregnant women (n= 175) with obstetric compl...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:

    authors: Ostlund E,Bremme K,Wiman B

    更新日期:1998-02-01 00:00:00

  • The clinical impact of fetal magnetic resonance imaging on management of CNS anomalies in the second trimester of pregnancy.

    abstract:OBJECTIVES:to evaluate the additional information of second trimester magnetic resonance imaging (MRI) compared to ultrasound in fetuses with identified or suspected central nervous system (CNS) anomalies and to study the clinical impact of the information on pregnancy management. DESIGN:prospective study during 2004-...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016349.2010.526184

    authors: Amini H,Axelsson O,Raiend M,Wikström J

    更新日期:2010-12-01 00:00:00

  • Maternal, fetal and amniotic fluid prolactin levels in term and post-term pregnancies.

    abstract::Prolactin (PRL) levels in maternal serum, amniotic fluid and mixed cord blood from 11 women with post-term pregnancies and 64 women with normal term pregnancies were measured by immunoenzymetric assay in order to investigate their possible role in the onset of labor. No differences were found between term and post-ter...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016349309013376

    authors: Demir N,Celiloglu M,Thomassen PA,Onvural A,Erten O

    更新日期:1993-04-01 00:00:00

  • Excessive hypertriglyceridemia and pancreatitis in pregnancy. Association with deficiency of lipoprotein lipase.

    abstract::Acute pancreatitis verified at laparotomy occurred in the 37th week in 1 of 4 women who developed excessive hypertriglyceridemia (type V hyperlipoproteinemia) during pregnancy. The hypertriglyceridemia was associated with and possibly caused by deficiency of lipoprotein lipase, measured as the NaCl sensitive component...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016348109154115

    authors: Lykkesfeldt G,Bock JE,Pedersen FD,Meinertz H,Faergeman O

    更新日期:1981-01-01 00:00:00