当前位置： SCI文献检索 > ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA期刊下所有文献 > Prediction of postpartum hemorrhage in women with gestational hypertension or mild preeclampsia at term.

Prediction of postpartum hemorrhage in women with gestational hypertension or mild preeclampsia at term.

Abstract：

OBJECTIVE:To assess whether postpartum hemorrhage can be predicted in women with gestational hypertension or mild preeclampsia at term. DESIGN:A cohort study in which we used data from our multicentre randomized controlled trial (HYPITAT trial). SETTING:The study was conducted in 38 hospitals in the Netherlands between 2005 and 2008. POPULATION:Women with gestational hypertension or mild preeclampsia at term (n = 1132). METHODS:An antepartum model (model A) and an antepartum/intrapartum model (model B) were created using logistic regression. The predictive capacity of the models was assessed with receiver operating characteristic analysis and calibration. MAIN OUTCOME MEASURE:Postpartum hemorrhage, defined as blood loss >1000 mL within 24 h after delivery. RESULTS:Postpartum hemorrhage occurred in 118 (10.4%) women. Maternal age (odds ratio 1.03), prepregnancy body mass index (odds ratio 0.96), and women with preeclampsia (odds ratio 1.5) were independent antepartum prognostic variables of postpartum hemorrhage. Intrapartum variables incorporated in the model were gestational age at delivery (odds ratio 1.2), duration of dilatation stage (odds ratio 1.1), and episiotomy (odds ratio 1.5). Model A and model B showed moderate discrimination, with areas under the receiver operating characteristic curve of 0.59 (95% confidence interval 0.53-0.64) and 0.64 (95% confidence interval 0.59-0.70), respectively. Calibration was moderate for model A (Hosmer-Lemeshow p = 0.26) but better for model B (Hosmer-Lemeshow p = 0.36). The rates of postpartum hemorrhage ranged from 4% (lowest 10%) to 22% (highest 10%). CONCLUSION:In the assessment of performance of a prediction model, calibration is more important than discriminative capacity. Our prediction model shows that for women with gestational hypertension or mild preeclampsia at term, distinction between low and high risk of developing postpartum hemorrhage is possible when antepartum and intrapartum variables are combined.

journal_name

Acta Obstet Gynecol Scand

journal_title

Acta obstetricia et gynecologica Scandinavica

authors

Koopmans CM,van der Tuuk K,Groen H,Doornbos JP,de Graaf IM,van der Salm PC,Porath MM,Kuppens SM,Wijnen EJ,Aardenburg R,van Loon AJ,Akerboom BM,van der Lans PJ,Mol BW,van Pampus MG,HYPITAT study group.

doi

10.1111/aogs.12352

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

399-407

issue

eissn

0001-6349

issn

1600-0412

journal_volume

pub_type

杂志文章

在线工具

Prediction of postpartum hemorrhage in women with gestational hypertension or mild preeclampsia at term.