Abstract:
OBJECTIVE:To assess the effect of interleukin (IL)-2 combined with highly active antiretroviral therapy (HAART) on HIV-1 pro-viral DNA quantification in HIV-1-infected patients with CD4<200/mm3. PATIENTS AND METHODS:Seventy patients with CD4<200 cells/mm3 and CV<1000 copies/ml were enrolled in a 6-month randomized controlled study to evaluate the subcutaneous injection of IL-2 in addition to HAART versus HAART alone. Then, in a non-comparative phase from week 28 to week 80, IL-2 was proposed to patients from both groups. The HIV-1 pro-viral DNA was quantified at baseline, week 24 and week 50 by a real-time polymerase chain reaction (PCR) assay in peripheral blood mononuclear cells (PBMC). Analysis of resistance mutations was performed at baseline and after 6-months of IL-2. RESULTS:HIV-1 DNA level in PBMC increased significantly in patients treated with 6 months of HAART combined to IL-2 (+0.24 log10, P=0.009) compared to a slight decrease in patients treated with HAART alone (-0.05 log10). Moreover, a DNA increase was observed in control group patients when receiving 6 months of IL-2 (+0.34 log10). No increase of HIV-1 DNA was seen when this measure was expressed per million CD4 cells; it was probably hidden by the intense increase of CD4 lymphocytes after 6 months of IL-2 administration. No evolution of resistance mutations in pro-viral DNA was observed during 6 months of IL-2, despite the increase of pro-viral DNA and the occurrence of transient increase of viraemia. CONCLUSION:Administration of IL-2 combined with HAART in HIV-1 infected-patients with advanced disease led to an increase of HIV-1 pro-viral DNA per million PBMC without virological failure or emergence of resistance.
journal_name
Antivir Therjournal_title
Antiviral therapyauthors
Delaugerre C,Gourlain K,Tubiana R,Carcelain G,Marcelin AG,Chouquet C,Mouroux M,Duvivier C,Autran B,Costagliola D,Katlama C,Calvez Vsubject
Has Abstractpub_date
2003-06-01 00:00:00pages
233-7issue
3eissn
1359-6535issn
2040-2058journal_volume
8pub_type
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journal_title:Antiviral therapy
pub_type: 杂志文章
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journal_title:Antiviral therapy
pub_type: 杂志文章,多中心研究
doi:
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journal_title:Antiviral therapy
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journal_title:Antiviral therapy
pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
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journal_title:Antiviral therapy
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journal_title:Antiviral therapy
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Antiviral therapy
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pub_type: 临床试验,杂志文章
doi:
更新日期:2005-01-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2018-01-01 00:00:00
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doi:
更新日期:2007-01-01 00:00:00
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更新日期:2013-01-01 00:00:00
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journal_title:Antiviral therapy
pub_type: 杂志文章,评审
doi:
更新日期:2001-01-01 00:00:00
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journal_title:Antiviral therapy
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更新日期:2011-01-01 00:00:00
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更新日期:2014-01-01 00:00:00
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