Cure of orthopaedic infection with Scedosporium prolificans, using voriconazole plus terbinafine, without the need for radical surgery.


:Scedosporium prolificans infections of normal hosts usually require extensive debridement and sometimes amputation to effect cure, due to the intrinsic resistance of this species to available antifungal agents. Newer agents have not tested favourably. Variable results are obtained with voriconazole, and 100% resistance is described with echinocandins. Itraconazole and terbinafine has offered synergy against various moulds including S. prolificans. In vivo success is reported with the azole/terbinafine combination in S. apiospermum pulmonary infection and Pythium insidiosum periorbital cellulitis. We report a case of orthopaedic infection in a non-immunocompromised host with S. prolificans, in which the combinations of itraconazole/terbinafine and voriconazole/terbinafine showed synergy in vitro, and success was achieved without radical surgery, using voriconazole and terbinafine.






Gosbell IB,Toumasatos V,Yong J,Kuo RS,Ellis DH,Perrie RC




Has Abstract


2003-06-01 00:00:00
















  • Hospitalisations for mycoses as an indicator of socio-environmental vulnerability in the Brazilian Amazon-Savanna transition region.

    abstract:BACKGROUND:The infections caused by fungi represent a global concern and an important cause of hospital admissions in endemic areas. The influence of socio-environmental factors in infectious diseases has been documented; however, this phenomenon remains unclear regarding mycoses. OBJECTIVES:This study aimed to analys...


    pub_type: 杂志文章


    authors: da Silva LC,de Oliveira LVN,Silva FB,Santos JRN,de Araújo MLS,Mendes AGG,Miranda RCM,Santos DA,Holanda RA,Santos JRA

    更新日期:2020-02-01 00:00:00

  • A novel dimorphic pathogen, Emergomyces orientalis (Onygenales), agent of disseminated infection.

    abstract::A novel dimorphic fungus, Emergomyces orientalis sp. nov. a close relative of systemic pathogens in the family Ajellomycetaceae (Blastomyces, Histoplasma). The fungus is reported in a 64-year-old male from Shanxi, China. The patient developed disseminated skin lesions, productive cough with fever and showed nodular op...


    pub_type: 杂志文章


    authors: Wang P,Kenyon C,de Hoog S,Guo L,Fan H,Liu H,Li Z,Sheng R,Yang Y,Jiang Y,Zhang L,Xu Y

    更新日期:2017-05-01 00:00:00

  • Invasive aspergillosis: epidemiology and environmental study in haematology patients (Sfax, Tunisia).

    abstract::Invasive aspergillosis (IA) is a major opportunistic infection in haematology patients. Preventive measures are important to control IA because diagnosis is difficult and the outcome of treatment is poor. We prospectively examined the environmental contamination by Aspergillus and other fungal species and evaluated th...


    pub_type: 杂志文章


    authors: Hadrich I,Makni F,Sellami H,Cheikhrouhou F,Sellami A,Bouaziz H,Hdiji S,Elloumi M,Ayadi A

    更新日期:2010-09-01 00:00:00

  • Case Report. Maxillary sinus infection due to Emericella nidulans.

    abstract::Fungal infections of the maxillary sinus are frequently caused by Aspergillus species, particularly A. fumigatus. In otherwise healthy persons there is an association with overfilling of dental root canals, when zinc-containing filling materials were used. Below, a maxillary sinus aspergilloma is reported in a young i...


    pub_type: 信件


    authors: Horré R,Schumacher G,Marklein G,Krömer B,Wardelmann E,Gilges S,De Hoog GS,Wahl G,Schaal KP

    更新日期:2002-11-01 00:00:00

  • Dermatophytosis in schoolchildren in Ekpoma, Nigeria.

    abstract::Of 1400 pupils from two public primary schools in Ekpoma, Edo State, Nigeria, who were screened for dermatophyte infection, 188 (13.4%) were infected. The causative agents isolated included Microsporum audouinii in 88 (46.8%), Trichophyton mentagrophytes in 48 (25.5%), T. rubrum in 40 (21.3%), T. tonsurans in four (2....


    pub_type: 杂志文章


    authors: Enweani IB,Ozan CC,Agbonlahor DE,Ndip RN

    更新日期:1996-07-01 00:00:00

  • The spectrum of opportunistic filamentous fungi present in the CBS culture collection.

    abstract::The mould collection of the Centraalbureau voor Schimmelcultures, Baarn, The Netherlands, was screened for isolates originating from warm-blooded animals. The range of species indicates that distribution of clinically relevant, pathogenic or opportunistic strains over the fungal kingdom is non-random. Some opportunist...


    pub_type: 杂志文章,评审


    authors: de Hoog GS,Tan CS,Stalpers JA,Stegehuis G

    更新日期:1992-09-01 00:00:00

  • Clinical characteristics, rapid identification, molecular epidemiology and antifungal susceptibilities of Talaromyces marneffei infections in Shenzhen, China.

    abstract::Although case series of talaromycosis have been reported in China, their detailed clinical and microbiological characteristics have never been systematically profiled. In this study, we report the clinical characteristics, molecular epidemiology, rapid identification and antifungal susceptibilities of talaromycosis in...


    pub_type: 杂志文章


    authors: Lau SKP,Xing F,Tsang CC,Tang JYM,Tan YP,Ye H,Lau RWT,Chen JHK,Lo SKF,Woo PCY

    更新日期:2019-05-01 00:00:00

  • A rapid Candida albicans hyphal-form growth inhibition assay: determination of myelomonocytic-mediated antifungal activity.

    abstract::An in vitro microassay for the measurement of Candida albicans hyphal-form growth inhibition by myelomonocytic cells is described. The assay is rapid, easy-to-perform and objective. A Candida strain capable of in vitro dimorphic transition from yeast to hyphal form has been employed. The assay is based on the incorpor...


    pub_type: 杂志文章


    authors: Scaringi L,Blasi E,Cornacchione P,Bietta C,Bistoni F

    更新日期:1991-03-01 00:00:00

  • How can we optimise antifungal use in a solid organ transplant centre? Local epidemiology and antifungal stewardship implementation: A single-centre study.

    abstract:PURPOSE:We aimed to implement and to assess the impact of the antifungal stewardship programme (AFSp) on prescription appropriateness of antifungals, management and outcomes of candidaemia patients, and antifungal consumption and costs at our solid organ transplant (SOT) institute. METHODS:Local epidemiology of invasi...


    pub_type: 杂志文章


    authors: Mularoni A,Adamoli L,Polidori P,Ragonese B,Gioè SM,Pietrosi A,Tuzzolino F,Guadagnino G,Monaco F,Grossi PA,Conaldi PG,Luca A,Mikulska M

    更新日期:2020-07-01 00:00:00

  • Extracellular protease expression in Microsporum gypseum complex, its regulation and keratinolytic potential.

    abstract::Two soil isolates of Microsporum gypseum were studied for the production of extracellular proteases. Both the strains secreted protease on glucose-gelatin medium. The enzyme activity peaked on day 15 at 28 °C. Asparagine repressed protease yield. Sugars caused catabolite repression of protease formation. Protease acti...


    pub_type: 杂志文章


    authors: Singh CJ

    更新日期:2011-07-01 00:00:00

  • Unilateral renal phaeohyphomycosis due to Bipolaris spicifera in an immunocompetent child - rare case presentation and review of literature.

    abstract::Phaeohyphomycosis refers to infections caused by phaeoid fungi that can have an aggressive course in normal hosts. We report a case of left-sided renal phaeohyphomycosis due to Bipolaris spicifera in a 7-year-old immunocompetent male child. He presented with fever, dysuria, nausea, vomiting and flank pain. Examination...


    pub_type: 杂志文章,评审


    authors: Kaur R,Bala K

    更新日期:2015-07-01 00:00:00

  • Fungitoxicity of essential oils against dermatophytes.

    abstract::Sixteen essential oils were screened in vitro for their fungitoxicity against the two dermatophytes Trichophyton rubrum and Microsporum gypseum. Five oils (from Artemisia nelagrica, Caesulia axillaris, Chenopodium ambrosioides, Cymbopogon citratus and Mentha arvensis) showed strong activity and were assessed for their...


    pub_type: 杂志文章


    authors: Kishore N,Mishra AK,Chansouria JP

    更新日期:1993-05-01 00:00:00

  • A case of sporotrichosis treated successfully with oral fluconazole 200 mg once weekly.

    abstract::A case of fixed cutaneous sporotrichosis that developed on the extensor aspect of the left wrist of an 83-year-old woman was treated once a week with 200 mg of oral fluconazole. This dermatological lesion healed within 4 months, leaving a scar. No side-effects were seen. At the time of writing, 7 months after the end ...


    pub_type: 杂志文章


    authors: Yoshida M,Hiruma M,Tezuka T

    更新日期:1994-07-01 00:00:00

  • Candiduria in haematologic malignancy patients without a urinary catheter: nothing more than a frailty marker?

    abstract::There is scarcity of data regarding significance of candiduria in patients with haematologic malignancies and its association with invasive candidiasis. To that end, we retrospectively evaluated all hospitalised, non-intensive care unit patients with haematologic malignancies and candiduria during a 10-year period (20...


    pub_type: 杂志文章


    authors: Georgiadou SP,Tarrand J,Sipsas NV,Kontoyiannis DP

    更新日期:2013-05-01 00:00:00

  • A rescue therapy with a combination of caspofungin and liposomal amphotericin B or voriconazole in children with haematological malignancy and refractory invasive fungal infections.

    abstract::Combination treatment of paediatric invasive fungal infections (IFIs) has rarely been reported. A total of 17 children with 19 IFI episodes were enrolled in the study. The median age of the patients was 5.3 (range 0.5-17) years. IFI was classified as proven in 4, probable in 12 and possible in 3 episodes. These patien...


    pub_type: 杂志文章


    authors: Yilmaz D,Balkan C,Ay Y,Akin M,Karapinar B,Kavakli K

    更新日期:2011-05-01 00:00:00

  • Cost-effectiveness of amphotericin B formulations in the treatment of systemic fungal infections.

    abstract::Amphotericin formulations, indicated for invasive fungal infections (IFIs), vary in effectiveness, safety and costs. In Brazil, only the conventional formulation is provided by the Public Health System. The aim of this study was to perform a cost-effectiveness analysis comparing conventional amphotericin B (CAB), lipo...


    pub_type: 杂志文章


    authors: Borba HHL,Steimbach LM,Riveros BS,Tonin FS,Ferreira VL,Bagatim BAQ,Balan G,Pontarolo R,Wiens A

    更新日期:2018-10-01 00:00:00

  • Adherence of Malassezia furfur to human stratum corneum cells in vitro: a study of healthy individuals and patients with seborrhoeic dermatitis.

    abstract::The role of Malassezia furfur adherence to human stratum corneum cells in vitro was studied. The adherence assay was performed with one strain of M. furfur and stratum corneum cells from 30 healthy individuals and from 28 patients with seborrhoeic dermatitis. Stratum corneum cells from patients with seborrhoeic dermat...


    pub_type: 杂志文章


    authors: Bergbrant IM,Faergemann J

    更新日期:1994-06-01 00:00:00

  • Ocular tolerance of sertaconazole gel.

    abstract::The in vitro and in vivo tolerance of sertaconazole gel, a new topical azole antifungal, was studied. Ketoconazole gel (Panfungol) was used as a reference substance. The methods applied for tolerance assessment were the bovine corneal opacity and permeability test for the in vitro assay and a modified Draize test for ...


    pub_type: 杂志文章


    authors: Romero A,Grau MT,Villamayor F,Zapatero J,Mayordomo L,Tortajada A,Sacristán A,Ortiz JA

    更新日期:1996-01-01 00:00:00

  • Confocal laser scanning microscopy as a new valuable tool in the diagnosis of onychomycosis - comparison of six diagnostic methods.

    abstract::Onychomycosis is common and can mimic several different nail disorders. Accurate diagnosis is essential to choose the optimum antifungal therapy. The aim of this study was to evaluate the use of confocal laser scanning microscopy (CLSM) and optical coherence tomography (OCT) as new non-invasive diagnostic tools in ony...


    pub_type: 杂志文章


    authors: Rothmund G,Sattler EC,Kaestle R,Fischer C,Haas CJ,Starz H,Welzel J

    更新日期:2013-01-01 00:00:00

  • Effect of reducing agents on proteolytic and keratinolytic activity of enzymes of Microsporum gypseum.

    abstract::The effect of sodium sulphite, cysteine, glutathione, mercaptoethanol and dithioerythritol (0.1-10 mmol l-1) on the activity of proteases of Microsporum gypseum was studied using azocasein, cross-linked bovine serum albumin and keratin as substrates. With the substrate without disulphide bonds (casein) no stimulation ...


    pub_type: 杂志文章


    authors: Kunert J

    更新日期:1992-11-01 00:00:00

  • Inhibitory effect of nicotinamide on enzymatic activity of selected fungal strains causing skin infection.

    abstract::Pathogenicity of fungi is connected with their ability to easily penetrate the host tissues, survive in the infected host organism and use the elements of the host tissues as nutrients. Hence, the co-occurrence of pathogenic properties with the high enzymatic activity, which is manifested through the production of var...


    pub_type: 杂志文章


    authors: Ciebiada-Adamiec A,Małafiej E,Ciebiada I

    更新日期:2010-05-01 00:00:00

  • Cryptococcosis in cirrhotic patients.

    abstract::The objective of the present study was to report on three distinct forms of presentation of Cryptococcus neoformans infection in three cirrhotic patients. One patient had disseminated cryptococcosis with detection of the fungus in ascitic fluid, cerebrospinal fluid and blood; the second patient had pleural involvement...


    pub_type: 杂志文章


    authors: França AV,Carneiro M,dal Sasso K,Souza Cda S,Martinelli A

    更新日期:2005-01-01 00:00:00

  • Fluconazole susceptibility of Candida isolates from oropharyngeal candidosis.

    abstract::Fifty strains of Candida isolated from 38 patients with oropharyngeal candidosis were tested in vitro for fluconazole susceptibility with a disk diffusion test and for determination of minimal inhibitory concentrations (MICs). For 25 patients treated with fluconazole, the relationship between in vitro susceptibility a...


    pub_type: 杂志文章


    authors: Dannaoui E,Lacoste V,Prat C,Piens MA

    更新日期:1997-11-01 00:00:00

  • Effects of recombinant human granulocyte-colony stimulating factor on neutropenic mice infected with Candida albicans: acceleration of recovery from neutropenia and potentiation of anti-C. albicans resistance.

    abstract::The treatment of systemic candidal infection in neutropenic patients continues to be a major problem, and only 20% of patients survive despite treatment with amphotericin B (Amph B). Granulocyte colony-stimulating factor (G-CSF) is a haemopoietic glycoprotein that appears to control the survival, cycle, activation, pr...


    pub_type: 杂志文章


    authors: Hamood M,Bluche PF,De Vroey C,Corazza F,Bujan W,Fondu P

    更新日期:1994-03-01 00:00:00

  • [Controversies in the standardization of susceptibility testing on yeasts to azole antimycotics].

    abstract::Due to the different physical-chemical conditions of the therapeutical azoles it is necessary to choose an adequate testing procedure. In the group of azoles caused by its hydrophilia fluconazole susceptibility testing can be handled easily. However it is not possible to take the same test conditions for itraconazole ...


    pub_type: 杂志文章


    authors: Tintelnot K,Seibold M

    更新日期:1996-01-01 00:00:00

  • Posaconazole: clinical pharmacokinetics and drug interactions.

    abstract::Posaconazole represents an antifungal extended-spectrum triazole whose absolute bioavailability following oral drug administration is considerably variable. Special conditions including increased gastric pH values, malabsorption syndrome, diarrhoea, intake on an empty stomach and some concomitantly administered potent...


    pub_type: 杂志文章


    authors: Lipp HP

    更新日期:2011-01-01 00:00:00

  • Antifungal combinations in Mucorales: A microbiological perspective.

    abstract::Mucormycosis mostly affects immunocompromised patients and is associated with a high morbidity and mortality despite currently available treatments. In that context, combination therapy might be the key to a better outcome for these patients. Purpose of this review is to summarise and to discuss the current combinatio...


    pub_type: 杂志文章,评审


    authors: Schwarz P,Cornely OA,Dannaoui E

    更新日期:2019-09-01 00:00:00

  • Histopathologic and histochemical characterization of calcified structures in hamsters inoculated with Paracoccidioides brasiliensis.

    abstract::In pathogenicity studies of 31 Paracoccidioides brasiliensis isolates preserved using Castellani's method we intraperitoneally inoculated 104 young adult hamsters and found laminated concentric structures and calcified appearance that resembled Schaumann bodies, in 43 of them, especially in animals with apparently goo...


    pub_type: 杂志文章


    authors: Essayag SM,Landaeta ME,Hartung C,Magaldi S,Spencer L,Suárez R,García F,Pérez E

    更新日期:2002-11-01 00:00:00

  • Tinea faciei incognito due to Trichophyton rubrum as a result of autoinoculation from onychomycosis.

    abstract::The localisation of a dermatophytosis on the face is rare. Differential diagnoses include a broad range of dermatological disorders, e. g. contact dermatitis, psoriasis vulgaris, seborrhoeic dermatitis, demodicosis, and polymorphic photo eruptions. Two patients suffering from tinea faciei incognito caused by Trichophy...


    pub_type: 杂志文章


    authors: Nenoff P,Mügge C,Herrmann J,Keller U

    更新日期:2007-01-01 00:00:00

  • A 7-year survey of dermatophytoses in Crete, Greece.

    abstract::Dermatophytoses are of worldwide distribution. Epidemiological studies concerning dermatophyte infections have been performed in many countries and differences in the incidence and the aetiological agents have been reported in different geographical locations. This study was undertaken to investigate the prevailing sp...


    pub_type: 杂志文章


    authors: Maraki S,Nioti E,Mantadakis E,Tselentis Y

    更新日期:2007-11-01 00:00:00