Abstract:
:Scedosporium prolificans infections of normal hosts usually require extensive debridement and sometimes amputation to effect cure, due to the intrinsic resistance of this species to available antifungal agents. Newer agents have not tested favourably. Variable results are obtained with voriconazole, and 100% resistance is described with echinocandins. Itraconazole and terbinafine has offered synergy against various moulds including S. prolificans. In vivo success is reported with the azole/terbinafine combination in S. apiospermum pulmonary infection and Pythium insidiosum periorbital cellulitis. We report a case of orthopaedic infection in a non-immunocompromised host with S. prolificans, in which the combinations of itraconazole/terbinafine and voriconazole/terbinafine showed synergy in vitro, and success was achieved without radical surgery, using voriconazole and terbinafine.
journal_name
Mycosesjournal_title
Mycosesauthors
Gosbell IB,Toumasatos V,Yong J,Kuo RS,Ellis DH,Perrie RCdoi
10.1046/j.1439-0507.2003.00878.xsubject
Has Abstractpub_date
2003-06-01 00:00:00pages
233-6issue
5-6eissn
0933-7407issn
1439-0507pii
878journal_volume
46pub_type
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