Abstract:
:Melanoma is the most aggressive form of skin cancer and is notoriously resistant to all current modalities of cancer therapy. A large set of genetic, functional and biochemical studies suggest that melanoma cells become 'bullet proof' against a variety of chemotherapeutic drugs by exploiting their intrinsic resistance to apoptosis and by reprogramming their proliferation and survival pathways during melanoma progression. In recent years, the identification of molecules involved in the regulation and execution of apoptosis, and their alteration in melanoma, have provided new insights into the molecular basis for melanoma chemoresistance. With this knowledge in hand, the challenge is now to devise strategies potent enough to compensate or bypass these cell death defects and improve the actual poor prognosis of patients at late stages of the disease.
journal_name
Oncogenejournal_title
Oncogeneauthors
Soengas MS,Lowe SWdoi
10.1038/sj.onc.1206454subject
Has Abstractpub_date
2003-05-19 00:00:00pages
3138-51issue
20eissn
0950-9232issn
1476-5594pii
1206454journal_volume
22pub_type
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