A well-conserved Plasmodium falciparum var gene shows an unusual stage-specific transcript pattern.

abstract：:Prokaryotes protect their genomes from foreign DNA with a diversity of defence mechanisms, including a widespread restriction-modification (R-M) system involving phosphorothioate (PT) modification of the DNA backbone. Unlike classical R-M systems, highly partial PT modification of consensus motifs in bacterial genomes...

journal_title：Molecular microbiology

authors： Cao B,Cheng Q,Gu C,Yao F,DeMott MS,Zheng X,Deng Z,Dedon PC,You D

更新日期：2014-08-01 00:00:00

abstract：:Fungi defend their ecological niche against antagonists by producing antibiosis molecules. Some of these molecules are only produced upon confrontation with the antagonist. The basidiomycete Coprinopsis cinerea induces the expression of the sesquiterpene synthase-encoding gene cop6 and its two neighboring genes coding...

journal_title：Molecular microbiology

authors： Stöckli M,Morinaka BI,Lackner G,Kombrink A,Sieber R,Margot C,Stanley CE,deMello AJ,Piel J,Künzler M

更新日期：2019-08-01 00:00:00

abstract：:The RusA protein of Escherichia coli is a DNA structure-specific endonuclease that resolves Holliday junction intermediates formed during DNA replication, recombination and repair by introducing symmetrically paired incisions 5' to CC dinucleotides. It is encoded by the defective prophage DLP12, which raises the possi...

journal_title：Molecular microbiology

authors： Sharples GJ,Bolt EL,Lloyd RG

更新日期：2002-04-01 00:00:00

abstract：:Toxin-antitoxin loci have been identified in almost all free-living prokaryotes, often in high copy numbers. The biological function and molecular targets of the abundant vapBC loci are not yet known. Here we analyse the vapBC loci of Salmonella LT2 and Shigella plasmid pMYSH6000. Both loci encode putative PIN (PilT N...

journal_title：Molecular microbiology

authors： Winther KS,Gerdes K

更新日期：2009-05-01 00:00:00

abstract：:We have cloned, characterized and inactivated genes encoding putative UspA paralogues in Escherichia coli. The yecG (uspC), yiiT (uspD) and ydaA (uspE) genes were demonstrated to encode protein pro-ducts and these were mapped to spots in the E. coli proteomic database. Expression analysis using chromosomal transcripti...

journal_title：Molecular microbiology

authors： Gustavsson N,Diez A,Nyström T

更新日期：2002-01-01 00:00:00

abstract：UNLABELLED:Haem Nitric oxide/OXygen (H-NOX) binding domains are a family of haemoprotein sensors that are widespread in bacterial genomes, but limited information is available on their function. Legionella pneumophila is the only prokaryote found, thus far, to encode two H-NOX proteins. This paper presents data support...

journal_title：Molecular microbiology

authors： Carlson HK,Vance RE,Marletta MA

更新日期：2010-08-01 00:00:00

abstract：:We identified interactions between the conserved bacterial replication initiator and transcription factor DnaA and the nucleoid-associated protein Rok of Bacillus subtilis. DnaA binds directly to clusters of DnaA boxes at the origin of replication and elsewhere, including the promoters of several DnaA-regulated genes....

journal_title：Molecular microbiology

authors： Seid CA,Smith JL,Grossman AD

更新日期：2017-03-01 00:00:00

abstract：:Two pathogenic species within the genus Neisseria cause the diseases gonorrhoea and meningitis. While vaccines are available to protect against four N. meningitidis serogroups, there is currently no commercial vaccine to protect against serogroup B or against N. gonorrhoeae. Moreover, the available vaccines have signi...

journal_title：Molecular microbiology

authors： Noinaj N,Buchanan SK,Cornelissen CN

更新日期：2012-10-01 00:00:00

abstract：:A key component to the success of Mycobacterium tuberculosis as a pathogen is the ability to sense and adapt metabolically to the diverse range of conditions encountered in vivo, such as oxygen tension, environmental pH and nutrient availability. Although nitrogen is an essential nutrient for every organism, little is...

journal_title：Molecular microbiology

authors： Williams KJ,Jenkins VA,Barton GR,Bryant WA,Krishnan N,Robertson BD

更新日期：2015-09-01 00:00:00

abstract：:The CovR/S two-component system regulates the transcription of many genes that are crucial for the virulence of Streptococcus pyogenes (group A Streptococcus, GAS). Previously, we demonstrated that one gene repressed directly by CovR is rivR, which encodes a member of the RofA-like family of transcriptional regulators...

journal_title：Molecular microbiology

authors： Roberts SA,Scott JR

更新日期：2007-12-01 00:00:00

abstract：:It is now well established that the sigma S subunit of RNA polymerase is a master regulator in a complex regulatory network that governs the expression of many stationary-phase-inducible genes in Escherichia coli. In this review, more recent findings will be summarized that demonstrate that sigma S also acts as a glob...

journal_title：Molecular microbiology

authors： Hengge-Aronis R

更新日期：1996-09-01 00:00:00

abstract：:Erwinia chrysanthemi, a phytopathogenic bacterium, produces a protease inhibitor which is a low-molecular-weight, heat-stable protein. In addition to its action on the three E. chrysanthemi extracellular proteases A, B and C, it also strongly inhibits the 50 kD extracellular protease of Serratia marcescens. Its struct...

journal_title：Molecular microbiology

authors： Létoffé S,Delepelaire P,Wandersman C

更新日期：1989-01-01 00:00:00

abstract：:The translational roles of the Shine-Dalgarno sequence, the initiation codon, the space between them, and the second codon have been studied. The Shine-Dalgarno sequence UAAGGAGG initiated translation roughly four times more efficiently than did the shorter AAGGA sequence. Each Shine-Dalgarno sequence required a minim...

journal_title：Molecular microbiology

authors： Ringquist S,Shinedling S,Barrick D,Green L,Binkley J,Stormo GD,Gold L

更新日期：1992-05-01 00:00:00

abstract：:The LuxR regulatory protein of Vibrio harveyi as well as the autoinducer molecule, N-(3-hydroxybutanoyl) homoserine lactone, are known to be required for expression of luminescence. Although LuxR has been implicated in the activation of the promoter of the lux operon of V. harveyi, and can bind to two distinct sites u...

journal_title：Molecular microbiology

authors： Miyamoto CM,Smith EE,Swartzman E,Cao JG,Graham AF,Meighen EA

更新日期：1994-10-01 00:00:00

abstract：:Pyruvoyl-dependent histidine decarboxylases are produced as proenzymes that mature by cleavage followed by formation of the pyruvoyl prosthetic group. The histidine decarboxylation pathway of Streptococcus thermophilus CHCC1524 that consists of the pyruvoyl-dependent histidine decarboxylase HdcA and the histidine/hist...

journal_title：Molecular microbiology

authors： Trip H,Mulder NL,Rattray FP,Lolkema JS

更新日期：2011-02-01 00:00:00

abstract：:The mitis group streptococci (MGS) are widespread in the oral cavity and are traditionally associated with oral health. However, these organisms have many attributes that contribute to the development of pathogenic oral communities. MGS adhere rapidly to saliva-coated tooth surfaces, thereby providing an attachment su...

journal_title：Molecular microbiology

authors： Whitmore SE,Lamont RJ

更新日期：2011-07-01 00:00:00

abstract：:When Escherichia coli is exposed to redox-cycling drugs, its SoxR transcription factor is activated by oxidation of its [2Fe-2S] cluster. In aerobic cells these drugs generate superoxide, and because superoxide dismutase (SOD) is a member of the SoxRS regulon, superoxide was initially thought to be the activator of So...

journal_title：Molecular microbiology

authors： Gu M,Imlay JA

更新日期：2011-03-01 00:00:00

abstract：:Mycoplasma hyopneumoniae induces respiratory disease in swine by colonizing cilia causing ciliostasis, cilial loss and epithelial cell death. Heparin binds to M. hyopneumoniae cells in a dose-dependent manner and blocks its ability to adhere to porcine cilia. We show here that Mhp493 (P216), a paralogue of the cilium ...

journal_title：Molecular microbiology

authors： Wilton J,Jenkins C,Cordwell SJ,Falconer L,Minion FC,Oneal DC,Djordjevic MA,Connolly A,Barchia I,Walker MJ,Djordjevic SP

更新日期：2009-02-01 00:00:00

abstract：:Recent studies examining the molecular mechanisms of isoniazid (INH) resistance in Mycobacterium tuberculosis have demonstrated that a significant percentage of drug-resistant strains are mutated in the katG gene which encodes a catalase-peroxidase, and the majority of these alterations are missense mutations which re...

journal_title：Molecular microbiology

authors： Rouse DA,DeVito JA,Li Z,Byer H,Morris SL

更新日期：1996-11-01 00:00:00

abstract：:The serine-threonine kinase TOR, the Target of Rapamycin, is an important regulator of nutrient, energy and stress signaling in eukaryotes. Sch9, a Ser/Thr kinase of AGC family (the cAMP-dependent PKA, cGMP- dependent protein kinase G and phospholipid-dependent protein kinase C family), is a substrate of TOR. Here, we...

journal_title：Molecular microbiology

authors： Alves de Castro P,Dos Reis TF,Dolan SK,Oliveira Manfiolli A,Brown NA,Jones GW,Doyle S,Riaño-Pachón DM,Squina FM,Caldana C,Singh A,Del Poeta M,Hagiwara D,Silva-Rocha R,Goldman GH

更新日期：2016-11-01 00:00:00

abstract：:Vegetative replication and partitioning of many plasmids and some chromosomes of alphaproteobacteria are directed by their repABC operons. RepA and RepB proteins direct the partitioning of replicons to daughter cells, while RepC proteins are replication initiators, although they do not resemble any characterized repli...

journal_title：Molecular microbiology

authors： Pinto UM,Flores-Mireles AL,Costa ED,Winans SC

更新日期：2011-09-01 00:00:00

abstract：:Deprivation of FtsN, the last protein in the hierarchy of divisome assembly, causes the disassembly of other elements from the division ring, even extending to already assembled proto-ring proteins. Therefore the stability and function of the divisome to produce rings active in septation is not guaranteed until FtsN i...

journal_title：Molecular microbiology

authors： Rico AI,García-Ovalle M,Palacios P,Casanova M,Vicente M

更新日期：2010-05-01 00:00:00

abstract：:In the past, ultrastructural investigations of Leishmania mexicana amastigotes revealed structures that were tentatively identified as autophagosomes. This study has now provided definitive data that autophagy occurs in the parasite during differentiation both to metacyclic promastigotes and to amastigotes, autophagos...

journal_title：Molecular microbiology

authors： Williams RA,Tetley L,Mottram JC,Coombs GH

更新日期：2006-08-01 00:00:00

abstract：:Iron is a member of a small group of nutrients that limits aquatic primary production. Mechanisms for utilizing iron have to be efficient and adapted according to the ecological niche. In respect to iron acquisition cyanobacteria, prokaryotic oxygen evolving photosynthetic organisms can be divided into siderophore- an...

journal_title：Molecular microbiology

authors： Rudolf M,Kranzler C,Lis H,Margulis K,Stevanovic M,Keren N,Schleiff E

更新日期：2015-08-01 00:00:00

abstract：:Cell division in prokaryotes initiates with assembly of the Z-ring at midcell, which, in Escherichia coli, is tethered to the inner leaflet of the cytoplasmic membrane through a direct interaction with FtsA, a widely conserved actin homolog. The Z-ring is comprised of polymers of tubulin-like FtsZ and has been suggest...

journal_title：Molecular microbiology

authors： Conti J,Viola MG,Camberg JL

更新日期：2018-02-01 00:00:00

abstract：:The wrinkly spreader (WS) genotype of Pseudomonas fluorescens SBW25 colonizes the air-liquid interface of spatially structured microcosms resulting in formation of a thick biofilm. Its ability to colonize this niche is largely due to overproduction of a cellulosic polymer, the product of the wss operon. Chemical analy...

journal_title：Molecular microbiology

authors： Spiers AJ,Bohannon J,Gehrig SM,Rainey PB

更新日期：2003-10-01 00:00:00

abstract：:While examining the molecular basis for the lack of actin-based motility for the non-pathogenic spotted fever group (SFG) R. peacockii, we identified a novel insertion sequence (IS) element, ISRpe1, disrupting the coding sequence of rickA, demonstrated to induce actin-tail polymerization for the SFG rickettsiae. This ...

journal_title：Molecular microbiology

authors： Simser JA,Rahman MS,Dreher-Lesnick SM,Azad AF

更新日期：2005-10-01 00:00:00

abstract：:Each bacterium has to co-ordinate its growth with division to ensure genetic stability of the population. Consequently, cell division and growth are tightly regulated phenomena, albeit different bacteria utilise one of several alternative regulatory mechanisms to maintain control. Here we consider GpsB, which is linke...

journal_title：Molecular microbiology

authors： Rismondo J,Cleverley RM,Lane HV,Großhennig S,Steglich A,Möller L,Mannala GK,Hain T,Lewis RJ,Halbedel S

更新日期：2016-03-01 00:00:00

abstract：:The heterotrimeric G-protein pathway is a ubiquitous eukaryotic signalling module that is known to regulate growth and differentiation in many plant pathogens. We previously identified Pigpa1, a gene encoding a G-protein alpha subunit from the potato late blight pathogen Phytophthora infestans. P. infestans belongs to...

journal_title：Molecular microbiology

authors： Latijnhouwers M,Ligterink W,Vleeshouwers VG,van West P,Govers F

更新日期：2004-02-01 00:00:00

abstract：:We have cloned the rpoD gene encoding the principal sigma (sigma) factor of Helicobacter pylori. The deduced amino acid sequence reveals a predicted polypeptide of 676 residues that has amino acid homology with the principal sigma factors of a number of divergent prokaryotes. We have designated this factor sigma80. Am...

journal_title：Molecular microbiology

authors： Beier D,Spohn G,Rappuoli R,Scarlato V

更新日期：1998-10-01 00:00:00