Abstract：
:The var multicopy gene family encodes Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) variant antigens, which, through their ability to adhere to a variety of host receptors, are thought to be important virulence factors. The predominant expression of a single cytoadherent PfEMP1 type on an infected red blood cell, and the switching between different PfEMP1 types to evade host protective antibody responses, are processes thought to be controlled at the transcriptional level. Contradictory data have been published on the timing of var gene transcription. Reverse transcription-polymerase chain reaction (RT-PCR) data suggested that transcription of the predominant var gene occurs in the later (pigmented trophozoite) stages, whereas Northern blot data indicated such transcripts only in early (ring) stages. We investigated this discrepancy by Northern blot, with probes covering a diverse var gene repertoire. We confirm that almost all var transcript types were detected only in ring stages. However, one type, the well-conserved varCSA transcript, was present constitutively in different laboratory parasites and does not appear to undergo antigenic variation. Although varCSA has been shown to encode a chondroitin sulphate A (CSA)-binding PfEMP1, we find that the presence of full-length varCSA transcripts does not correlate with the CSA-binding phenotype.
journal_name
Mol Microbioljournal_title
Molecular microbiologyauthors
Kyes SA,Christodoulou Z,Raza A,Horrocks P,Pinches R,Rowe JA,Newbold CIdoi
10.1046/j.1365-2958.2003.03505.xsubject
Has Abstractpub_date
2003-06-01 00:00:00pages
1339-48issue
5eissn
0950-382Xissn
1365-2958pii
3505journal_volume
48pub_type
杂志文章abstract：:Salmonella typhimurium responds to a variety of environmental stresses by accumulating the alternative sigma factor sigmaS. The repertoire of sigmaS -dependent genes that are subsequently expressed confers tolerance to a variety of potentially lethal conditions including low pH and stationary phase. The mechanism(s) r...
journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1046/j.1365-2958.1999.01581.x
更新日期：1999-10-01 00:00:00
abstract：:Bacterial ribosome requires elongation factor P to translate fragments harbouring consecutive proline codons. Given the abundance of ORFs with potential EF-P regulated sites, EF-P was assumed to be constitutively expressed. Here, we report that the intracellular pathogen Salmonella enterica serovar Typhimurium decreas...
journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1111/mmi.13454
更新日期：2016-10-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1046/j.1365-2958.1999.01632.x
更新日期：1999-11-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1111/j.1365-2958.1993.tb01256.x
更新日期：1993-09-01 00:00:00
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doi：10.1046/j.1365-2958.2002.02949.x
更新日期：2002-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：2006-09-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1111/j.1365-2958.1994.tb00338.x
更新日期：1994-02-01 00:00:00
abstract：:A hallmark of the biofilm architecture is the presence of microcolonies. However, little is known about the underlying mechanisms governing microcolony formation. In the pathogen Pseudomonas aeruginosa, microcolony formation is dependent on the two-component regulator MifR, with mifR mutant biofilms exhibiting an over...
journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1111/mmi.12018
更新日期：2012-11-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2008-05-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1111/j.1365-2958.2009.06720.x
更新日期：2009-06-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
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更新日期：2012-12-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1111/j.1365-2958.2011.07555.x
更新日期：2011-04-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1111/mmi.14666
更新日期：2020-12-13 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
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更新日期：2018-09-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1111/j.1365-2958.2008.06253.x
更新日期：2008-06-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1046/j.1365-2958.2001.02553.x
更新日期：2001-08-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1111/mmi.12692
更新日期：2014-08-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1111/j.1365-2958.2008.06334.x
更新日期：2008-08-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
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更新日期：2006-04-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1111/j.1365-2958.1992.tb00859.x
更新日期：1992-05-01 00:00:00
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pub_type： 评论,杂志文章
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更新日期：2010-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2004-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2004-07-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1111/j.1365-2958.1989.tb00259.x
更新日期：1989-08-01 00:00:00
abstract：:Proteus mirabilis is a common cause of urinary tract infection (UTI) in individuals with structural abnormalities or long-term catheterization. The expression of mannose-resistant/Proteus-like (MR/P) fimbria is phase variable because of the inversion of a 251 bp DNA fragment that carries the promoter for the mrp opero...
journal_title：Molecular microbiology
pub_type： 杂志文章
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更新日期：2002-08-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章,评审
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更新日期：1992-09-01 00:00:00
abstract：:Two pathogenic species within the genus Neisseria cause the diseases gonorrhoea and meningitis. While vaccines are available to protect against four N. meningitidis serogroups, there is currently no commercial vaccine to protect against serogroup B or against N. gonorrhoeae. Moreover, the available vaccines have signi...
journal_title：Molecular microbiology
pub_type： 杂志文章,评审
doi：10.1111/mmi.12002
更新日期：2012-10-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
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更新日期：2006-01-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1111/j.1365-2958.1994.tb00411.x
更新日期：1994-07-01 00:00:00
abstract：:In their natural habitats, microorganisms are often exposed to osmolality changes in the environment. The osmotic stress must be sensed and converted into an activity change of specific enzymes and transport proteins and/or it must trigger their synthesis such that the osmotic imbalance can be rapidly restored. On the...
journal_title：Molecular microbiology
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2958.1998.00875.x
更新日期：1998-07-01 00:00:00
