Long-term results of paclitaxel in FIGO stage III ovarian carcinoma.

Abstract:

:The combination of platinum and paclitaxel is the standard treatment of advanced ovarian carcinoma; however, recent studies have questioned the actual role of the combination as compared to either of the two agents alone. We report an open-label, two-center, phase II study of upfront paclitaxel for patients with histological diagnosis of stage III ovarian carcinoma. Treatment consisted of paclitaxel at 175 mg/m2 administered in a 3-h infusion every 21 days. Response was evaluated after the third course by either laparoscopy or exploratory laparotomy. Patients with stable or progressive disease discontinued treatment, whereas responding patients continued treatment until a maximum of six courses. Response, toxicity, time to progression (TTP) and survival were evaluated. From November 1993 to December 1995, 30 patients were accrued. All patients underwent primary cytoreduction; 17 (57%) and 13 (43%) patients had residual tumors <2 and >2 cm, respectively. Of 27 patients evaluable, objective responses were seen in 18 (66.4%) (95% CI 49.5-83.2)--12 complete (45%) and six partial (22%). Four patients had stable disease (15%) and five (18%) patients progressed. A total of 149 courses were administered to 30 patients, median 4 (range 1-6). Grade 3/4 neutropenia was seen in 13% of courses, peripheral neuropathy, myalgia and arthralgia were frequent, but transitory and relieved with analgesics. At a median follow-up time of 44.5 months (0-99) the TTP and median survival were 16.6 and 43.1 months, respectively. We conclude that single-agent paclitaxel is an effective and well-tolerated first-line treatment for advanced ovarian carcinoma.

journal_name

Anticancer Drugs

journal_title

Anti-cancer drugs

authors

Gallardo-Rincón D,Pérez-Landeros L,Oñate-Ocaña LF,Mohar A,Calderillo G,de la Garza J,Cabrera P,Sánchez B,Dueñas-Gonzalez A

doi

10.1097/00001813-200306000-00004

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

347-52

issue

5

eissn

0959-4973

issn

1473-5741

journal_volume

14

pub_type

临床试验,杂志文章
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  • Reversal of resistance against doxorubicin by a newly developed compound, oxalyl bis(N-phenyl)hydroxamic acid in vitro.

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    journal_title:Anti-cancer drugs

    pub_type: 杂志文章

    doi:10.1097/00001813-199810000-00013

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  • Dihydroartemisinin induces apoptosis in human leukemia cells HL60 via downregulation of transferrin receptor expression.

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  • MiR-29b suppresses proliferation and mobility by targeting SOX12 and DNMT3b in pancreatic cancer.

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    journal_title:Anti-cancer drugs

    pub_type: 杂志文章

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    authors: Fedier A,Poyet C,Perucchini D,Boulikas T,Fink D

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  • Novel taxanes.

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    journal_title:Anti-cancer drugs

    pub_type: 杂志文章,评审

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    journal_title:Anti-cancer drugs

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  • Therapeutic effects of the angiogenesis inhibitor TNP-470 against carcinomatous peritonitis in mice.

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    journal_title:Anti-cancer drugs

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  • Ceragenin CSA-13 induces cell cycle arrest and antiproliferative effects in wild-type and p53 null mutant HCT116 colon cancer cells.

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  • Feasibility and toxicity of CCNU therapy in elderly patients with glioblastoma multiforme.

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    authors: To KK,Ho YP,Au-Yeung SC

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    pub_type: 临床试验,杂志文章

    doi:10.1097/00001813-199904000-00003

    authors: van Zuylen L,Schellens JH,Goey SH,Pronk LC,de Boer-Dennert MM,Loos WJ,Ma J,Stoter G,Verweij J

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    doi:10.1097/CAD.0000000000000649

    authors: Song ZT,Zhang LW,Fan LQ,Kong JW,Mao JH,Zhao J,Wang FJ

    更新日期:2018-09-01 00:00:00

  • A case of glassy cell carcinoma of the uterine cervix effectively responding to chemotherapy with paclitaxel and carboplatin.

    abstract::Glassy cell carcinoma (GCC) of the uterine cervix is a highly malignant tumor and has a poor prognosis. As yet, no effective systemic chemotherapy to this tumor has been reported. Here we describe a case of recurrent GCC that responded to paclitaxel and carboplatin combination treatment. The patient, a 32-year-old wom...

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    pub_type: 杂志文章

    doi:10.1097/00001813-200108000-00010

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    更新日期:2001-08-01 00:00:00