Abstract:
:Twelve volunteers known to have airways that responded adversely to 2.0 MAC desflurane were recruited. Each volunteer inhaled three single breaths of each of 0.5, 1.0 and 2.0 MAC of sevoflurane, halothane, isoflurane, desflurane and balance air, with breaths of air between, whilst breathing nasally through a face mask attached to one of three filters that provided three different levels of humidification. The incidence of any adverse airway events was recorded. The anaesthetic inhaled significantly affected the incidence of adverse airway events (p < 0.001), with the least to most irritant being sevoflurane, halothane, isoflurane and desflurane. Increasing the concentration of anaesthetic also significantly increased the incidence of adverse airway events (p < 0.001). The filter used, and hence the level of humidification, did not affect the incidence of adverse airway events (p = 0.09), but repeated exposure caused a significant reduction in the incidence of adverse airway events (p < 0.001).
journal_name
Anaesthesiajournal_title
Anaesthesiaauthors
Wilkes AR,Raj N,Hall JEdoi
10.1046/j.1365-2044.2003.02965.xsubject
Has Abstractpub_date
2003-03-01 00:00:00pages
207-16issue
3eissn
0003-2409issn
1365-2044pii
2965ajournal_volume
58pub_type
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