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Comparative responsiveness of generic and specific quality-of-life instruments.

Abstract：

:We assessed the relative responsiveness of generic and specific quality of life instruments in 43 randomized controlled trials that compared head-to-head 31 generic and 84 specific instruments. Using weighted effect size as the metric of responsiveness, we assessed the impact of instrument type, disease category, and magnitude of underlying therapeutic effect on responsiveness, and assessed the responsiveness of specific instruments relative to the corresponding domains of generic measures. In studies with a nonzero therapeutic effect, specific instruments (mean = 0.57) were significantly more responsive than generic instruments (mean = 0.39, P =.01), and than the corresponding domains of generic instruments (mean = 0.40, P =.03). Studies with low, medium, and high therapeutic effects showed a corresponding gradation in responsiveness differences between specific and generic instruments. We conclude that, overall, specific instruments are more responsive than generic tools, and that investigators may come to misleading conclusions about relative instrument responsiveness if they include studies in which the magnitude of the underlying therapeutic effect is zero.

journal_name

J Clin Epidemiol

journal_title

Journal of clinical epidemiology

authors

Wiebe S,Guyatt G,Weaver B,Matijevic S,Sidwell C

doi

10.1016/s0895-4356(02)00537-1

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

52-60

issue

1

eissn

0895-4356

issn

1878-5921

pii

S0895435602005371

journal_volume

56

pub_type

杂志文章,评审

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