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Immune response to enzyme replacement therapy: single epitope control of antigen distribution from circulation.

Abstract：

:Immune response to replacement therapy has been reported for a range of therapeutic strategies being developed for the treatment of patients with genetic disease. The potential problem of immune response to enzyme replacement therapy has been investigated in alpha-L-iduronidase immunized rats, representing a model of the lysosomal storage disorder Hurler syndrome (alpha-L-iduronidase deficiency). The antibody response to alpha-L-iduronidase showed that the positional location of antibody reactivity was similar for different immunized rats, but the precise linear sequence epitopes identified, varied between rats. A monoclonal antibody reacting to an epitope in close proximity to one high antigenicity site on alpha-L-iduronidase was used to reproduce the in vivo effect of altered enzyme tissue distribution, previously observed in immunized rats infused with alpha-L-iduronidase. The study demonstrated that during an immune response, antibody reacting to a single epitope could partially control the tissue distribution of antigen from circulation.

journal_name

Mol Genet Metab

journal_title

Molecular genetics and metabolism

authors

Glaros EN,Turner CT,Parkinson EJ,Hopwood JJ,Brooks DA

doi

10.1016/s1096-7192(02)00148-8

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

127-35

issue

1-2

eissn

1096-7192

issn

1096-7206

pii

S1096719202001488

journal_volume

77

pub_type

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