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Genetic and epigenetic regulation schemes: need for an alternative paradigm.

Abstract：

:Self-organization of living cells results from the tangle of positive and negative feedback developed to ensure their homeostasis and/or their differentiation. There are three major means cellular regulation operates: the genetic, the epigenetic, and the metabolic ones. The regulation type in each of them has been overviewed. Further examination of relations between complexity and developmental stability points out sui generis properties of feedback loops, which are redundancy and pleiotropy. Prototypical schemes for positive and negative regulation with redundant and pleiotropic (including multifunctional) proteins are presented. They stress a theoretical shift from the analytical to the systemic framework. The systemic paradigm appears to be of increasing interest and importance in the study of concepts for the representation of genetic and epigenetic regulations.

journal_name

Mol Genet Metab

journal_title

Molecular genetics and metabolism

authors

Roux-Rouquie M

doi

10.1006/mgme.2000.3048

subject

Has Abstract

pub_date

2000-09-01 00:00:00

pages

1-9

issue

1-2

eissn

1096-7192

issn

1096-7206

pii

S1096-7192(00)93048-8

journal_volume

71

pub_type

杂志文章,评审

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