Abstract:
:In mammals the initiation of testis determination usually depends on the Y-chromosomal gene SRY. A few species, however, escape from this rule with a testis determination that is independent of SRY. The mole vole Ellobius lutescens is one of these species. It is not known how testis determination is initiated in this species but it has been suggested that a gene from the sex determination cascade usually acting downstream of SRY is mutated and has taken over the testis-determining function. At present SOX9 is the only candidate gene for which a testis-determining function in the absence of SRY has been observed. To test the hypothesis that testis differentiation in E. lutescens is initiated by SOX9, segregation analysis of SOX9 alleles was performed in an E. lutescens family. As there is no marker data available in this species we screened both Ellobius SOX9 introns for polymorphisms suitable for segregation studies. A biallelic polymorphism was found in the second intron of the SOX9 gene and analysis of this marker in the Ellobius family revealed an inheritance pattern completely independent of the sex of the animals. Thus, SOX9 can be excluded from being the testis-determining factor in E. lutescens. These results provide evidence for another possibly yet unknown gene besides SRY and SOX9 able to exert testis-determining function.
journal_name
Mol Genet Metabjournal_title
Molecular genetics and metabolismauthors
Baumstark A,Akhverdyan M,Schulze A,Reisert I,Vogel W,Just Wdoi
10.1006/mgme.2000.3105subject
Has Abstractpub_date
2001-01-01 00:00:00pages
61-6issue
1eissn
1096-7192issn
1096-7206pii
S1096-7192(00)93105-6journal_volume
72pub_type
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journal_title:Molecular genetics and metabolism
pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,随机对照试验
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