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From bench to bedside: a diagnostics framework for pharmacogenetics research.

Abstract：

:Although many genetic variants have been associated with differential drug responses, a very limited number of pharmacogenetic tests have entered common clinical practice. Pharmacogenetic tests that are successful address unmet medical needs, are clinically relevant, and have sufficient sensitivity, and specificity. In this respect, pharmacogenetics is no different from other diagnostics fields. Unmet medical need, clinical relevance, sensitivity, and specificity are discussed in the context of specific pharmacogenetic associations. These parameters are useful guides for researchers interested in translating pharmacogenetic findings from the bench to the bedside.

journal_name

Mol Genet Metab

journal_title

Molecular genetics and metabolism

authors

Katz DA

doi

10.1016/s1096-7192(02)00143-9

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

57-60

issue

1-2

eissn

1096-7192

issn

1096-7206

pii

S1096719202001439

journal_volume

77

pub_type

杂志文章,评审

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