Abstract:
:A higher frequency of acute promyelocytic leukemia (APL) has been noted in countries of Southern Europe and among 'Latino' patients of the United States with acute myeloid leukemia (AML). In order to discover whether there is any genetic predisposition to the disease, we analyzed microsatellites flanking PML and RARalpha genes in 29 t(15;17) APL patients from North Portugal and compared them with a control group of 123 healthy individuals. Fluorescent PCR products were analyzed using an automated capillary electrophoresis system and allele and haplotype frequencies of the two populations were determined. No significant differences were found, suggesting the same genetic origin of patients and healthy individuals. As suggested by the four microsatellites screened, MSI (microsatellite instability) does not explain the increased incidence of t(15;17) APL in this Portuguese population. These results intend to be a new approach to the study of APL, reflecting the particularity of the disease.
journal_name
Leukemiajournal_title
Leukemiaauthors
Martins S,Trigo F,Azevedo L,Silva MJ,Guimaraes JE,Amorim Adoi
10.1038/sj.leu.2402525subject
Has Abstractpub_date
2002-07-01 00:00:00pages
1353-7issue
7eissn
0887-6924issn
1476-5551journal_volume
16pub_type
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