Abstract：
:Many facets of health-related quality of life are diminished in obstructive sleep apnea (OSA) as they are in other chronic medical conditions. We speculated that impairment in health-related quality of life (HRQoL) might result from the fatigue and daytime somnolence associated with the sleep disorder, as an indirect result from the fragmentation of night-time sleep in OSA. Our hypothesis was that sleep fragmentation measures would correlate with poorer HRQoL measured by medical outcomes study (MOS) subscales. Thirty-nine patients with polysomnographically-confirmed OSA participated in this study. Pearson's correlations were performed with the following sleep architecture variables: wake after sleep onset, the total number of brief arousals, the number of respiratory-related arousals, the rate of respiratory events per hour, and total sleep time. To our surprise, although the total number of arousals was associated with health distress (r=-0.481, P < 0.005), it did not correlate with any other subscales indicating poorer physical and mental health. The relatively insensitive measure of total sleep time (TST) correlated in the expected direction with most subscales. However, after controlling for age and gender, respiratory disturbance indices (RDI) and/or number of arousals emerged as significantly associated with mobility, cognitive functioning, social functioning, energy and fatigue, and health distress. Our findings suggest that polysomnographic indicators of sleep quality and sleep continuity may be an important influence determining many aspects of HRQoL in OSA patients.
journal_name
J Sleep Resjournal_title
Journal of sleep researchauthors
Moore P,Bardwell WA,Ancoli-Israel S,Dimsdale JEdoi
10.1046/j.1365-2869.2001.00264.xsubject
Has Abstractpub_date
2001-12-01 00:00:00pages
303-8issue
4eissn
0962-1105issn
1365-2869pii
264journal_volume
10pub_type
杂志文章abstract：:Parkinson's disease (PD) is highly comorbid with sleep dysfunction. In contrast to motor symptoms, few therapeutic interventions exist to address sleep symptoms in PD. Subthalamic nucleus (STN) deep brain stimulation (DBS) treats advanced PD motor symptoms and may improve sleep architecture. As a proof of concept towa...
journal_title：Journal of sleep research
pub_type： 杂志文章
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journal_title：Journal of sleep research
pub_type： 杂志文章
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journal_title：Journal of sleep research
pub_type： 杂志文章
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更新日期：2020-05-28 00:00:00
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journal_title：Journal of sleep research
pub_type： 杂志文章,随机对照试验
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更新日期：2008-12-01 00:00:00
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journal_title：Journal of sleep research
pub_type： 杂志文章
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journal_title：Journal of sleep research
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Journal of sleep research
pub_type： 临床试验,杂志文章,多中心研究,评审
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更新日期：2003-12-01 00:00:00
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journal_title：Journal of sleep research
pub_type： 杂志文章
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journal_title：Journal of sleep research
pub_type： 杂志文章
doi：10.1111/j.1365-2869.2006.00525.x
更新日期：2006-06-01 00:00:00
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journal_title：Journal of sleep research
pub_type： 杂志文章
doi：10.1111/jsr.13277
更新日期：2021-01-25 00:00:00
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journal_title：Journal of sleep research
pub_type： 杂志文章
doi：10.1046/j.1365-2869.2000.00211.x
更新日期：2000-09-01 00:00:00
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journal_title：Journal of sleep research
pub_type： 杂志文章
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更新日期：2012-06-01 00:00:00
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journal_title：Journal of sleep research
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2869.2000.00214.x
更新日期：2000-09-01 00:00:00
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journal_title：Journal of sleep research
pub_type： 杂志文章
doi：10.1111/jsr.12097
更新日期：2014-04-01 00:00:00
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journal_title：Journal of sleep research
pub_type： 杂志文章
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更新日期：2012-04-01 00:00:00
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journal_title：Journal of sleep research
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更新日期：2018-04-01 00:00:00
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journal_title：Journal of sleep research
pub_type： 杂志文章
doi：10.1111/j.1365-2869.2011.00932.x
更新日期：2012-02-01 00:00:00
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journal_title：Journal of sleep research
pub_type： 杂志文章
doi：10.1111/j.1365-2869.2010.00845.x
更新日期：2010-12-01 00:00:00
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journal_title：Journal of sleep research
pub_type： 杂志文章
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journal_title：Journal of sleep research
pub_type： 杂志文章
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journal_title：Journal of sleep research
pub_type： 杂志文章
doi：10.1111/jsr.13129
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journal_title：Journal of sleep research
pub_type： 杂志文章
doi：10.1046/j.1365-2869.2000.00195.x
更新日期：2000-06-01 00:00:00
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journal_title：Journal of sleep research
pub_type： 杂志文章,实务指引
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journal_title：Journal of sleep research
pub_type： 杂志文章
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更新日期：2019-04-01 00:00:00
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journal_title：Journal of sleep research
pub_type： 杂志文章
doi：10.1111/j.1365-2869.1992.tb00025.x
更新日期：1992-06-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2013-06-01 00:00:00
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journal_title：Journal of sleep research
pub_type： 临床试验,杂志文章
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更新日期：2001-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-10-01 00:00:00
