Functional neuroimaging of normal human sleep by positron emission tomography.

Abstract:

:Functional neuroimaging using positron emission tomography has recently yielded original data on the functional neuroanatomy of human sleep. This paper attempts to describe the possibilities and limitations of the technique and clarify its usefulness in sleep research. A short overview of the methods of acquisition and statistical analysis (statistical parametric mapping, SPM) is presented before the results of PET sleep studies are reviewed. The discussion attempts to integrate the functional neuroimaging data into the body of knowledge already acquired on sleep in animals and humans using various other techniques (intracellular recordings, in situ neurophysiology, lesional and pharmacological trials, scalp EEG recordings, behavioural or psychological description). The published PET data describe a very reproducible functional neuroanatomy in sleep. The core characteristics of this 'canonical' sleep may be summarized as follows. In slow-wave sleep, most deactivated areas are located in the dorsal pons and mesencephalon, cerebellum, thalami, basal ganglia, basal forebrain/hypothalamus, prefrontal cortex, anterior cingulate cortex, precuneus and in the mesial aspect of the temporal lobe. During rapid-eye movement sleep, significant activations were found in the pontine tegmentum, thalamic nuclei, limbic areas (amygdaloid complexes, hippocampal formation, anterior cingulate cortex) and in the posterior cortices (temporo-occipital areas). In contrast, the dorso-lateral prefrontal cortex, parietal cortex, as well as the posterior cingulate cortex and precuneus, were the least active brain regions. These preliminary studies open up a whole field in sleep research. More detailed explorations of sleep in humans are now accessible to experimental challenges using PET and other neuroimaging techniques. These new methods will contribute to a better understanding of sleep functions.

journal_name

J Sleep Res

authors

Maquet P

doi

10.1046/j.1365-2869.2000.00214.x

subject

Has Abstract

pub_date

2000-09-01 00:00:00

pages

207-31

issue

3

eissn

0962-1105

issn

1365-2869

pii

jsr214

journal_volume

9

pub_type

杂志文章,评审
  • Sleeping difficulty, disease and mortality in older women: a latent class analysis and distal survival analysis.

    abstract::The aim of this study is to identify patterns of sleep difficulty in older women, to investigate whether sleep difficulty is an indicator for poorer survival, and to determine whether sleep difficulty modifies the association between disease and death. Data were from the Australian Longitudinal Study on Women's Health...

    journal_title:Journal of sleep research

    pub_type: 杂志文章

    doi:10.1111/jsr.12324

    authors: Leigh L,Hudson IL,Byles JE

    更新日期:2015-12-01 00:00:00

  • Fatigue-related impairment in the speed, accuracy and variability of psychomotor performance: comparison with blood alcohol levels.

    abstract::Cognitive performance is impaired by fatigue arising from sustained wakefulness and alcohol. Three recent papers directly compared the effects of increasing fatigue and blood alcohol concentration (%BAC) to provide a framework for understanding fatigue-related cognitive impairment. While the expression of fatigue-rela...

    journal_title:Journal of sleep research

    pub_type: 杂志文章

    doi:10.1111/j.1365-2869.2004.00438.x

    authors: Maruff P,Falleti MG,Collie A,Darby D,McStephen M

    更新日期:2005-03-01 00:00:00

  • No effect of 8-week time in bed restriction on glucose tolerance in older long sleepers.

    abstract::The aim of this study was to investigate the effects of 8 weeks of moderate restriction of time in bed (TIB) on glucose tolerance and insulin sensitivity in healthy older self-reported long sleepers. Forty-two older adults (ages 50-70 years) who reported average sleep durations of >or=8.5 h per night were assessed. Fo...

    journal_title:Journal of sleep research

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1365-2869.2008.00673.x

    authors: Zielinski MR,Kline CE,Kripke DF,Bogan RK,Youngstedt SD

    更新日期:2008-12-01 00:00:00

  • A 50-Hz electromagnetic field impairs sleep.

    abstract::In view of reports of health problems induced by low frequency (50-60 Hz) electromagnetic fields (EMF), we carried out a study in 18 healthy subjects, comparing sleep with and without exposure to a 50 Hz/1 mu Tesla electrical field. We found that the EMF condition was associated with reduced: total sleep time (TST), s...

    journal_title:Journal of sleep research

    pub_type: 杂志文章

    doi:10.1046/j.1365-2869.1999.00100.x

    authors: Akerstedt T,Arnetz B,Ficca G,Paulsson LE,Kallner A

    更新日期:1999-03-01 00:00:00

  • Factors of home dream recall: a structural equation model.

    abstract::Previous research has indicated that personality factors such as openness to experience, creativity, visual memory, attitude toward dreams, and sleep behavior is related to home dream recall frequency (DRF). However, a study investigating all areas simultaneously within one sample in order to determine the percentage ...

    journal_title:Journal of sleep research

    pub_type: 杂志文章

    doi:10.1046/j.1365-2869.2003.00344.x

    authors: Schredl M,Wittmann L,Ciric P,Götz S

    更新日期:2003-06-01 00:00:00

  • Sleep inhibition induced by amyloid-β oligomers is mediated by the cellular prion protein.

    abstract::Sleep is severely impaired in patients with Alzheimer's disease. Amyloid-β deposition in the brain of Alzheimer's disease patients is a key event in its pathogenesis and is associated with disrupted sleep, even before the appearance of cognitive decline. Because soluble amyloid-β oligomers are the key mediators of syn...

    journal_title:Journal of sleep research

    pub_type: 杂志文章

    doi:10.1111/jsr.13187

    authors: Del Gallo F,Bianchi S,Bertani I,Messa M,Colombo L,Balducci C,Salmona M,Imeri L,Chiesa R

    更新日期:2020-09-09 00:00:00

  • Sleep duration and mortality: a systematic review and meta-analysis.

    abstract::Epidemiologic studies have shown that sleep duration is associated with overall mortality. We conducted a systematic review of the associations between sleep duration and all-cause and cause-specific mortality. PubMed was systematically searched up to January, 2008 to identify studies examining the association between...

    journal_title:Journal of sleep research

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/j.1365-2869.2008.00732.x

    authors: Gallicchio L,Kalesan B

    更新日期:2009-06-01 00:00:00

  • Associations between quantitative sleep EEG and subsequent cognitive decline in older women.

    abstract::The pathophysiological processes of Alzheimer's dementia predate its clinical manifestation. Sleep disturbances can accelerate the aging process and are common features of dementia. This study examined whether quantitative sleep electroencephalogram changes predate the clinical development of mild cognitive impairment...

    journal_title:Journal of sleep research

    pub_type: 杂志文章

    doi:10.1111/jsr.12666

    authors: Djonlagic I,Aeschbach D,Harrison SL,Dean D,Yaffe K,Ancoli-Israel S,Stone K,Redline S

    更新日期:2019-06-01 00:00:00

  • Are serum ferritin and transferrin saturation risk markers for restless legs syndrome in young adults? Longitudinal and cross-sectional data from the Western Australian Pregnancy Cohort (Raine) Study.

    abstract::Restless legs syndrome has been associated with serum iron deficiency in clinical studies. However, studies investigating this relationship have had inconsistent results and there are no studies in young adults. Therefore, we investigated the relationship between serum measures of iron stores and restless legs syndrom...

    journal_title:Journal of sleep research

    pub_type: 杂志文章

    doi:10.1111/jsr.12741

    authors: Lammers N,Curry-Hyde A,Smith AJ,Eastwood PR,Straker LM,Champion D,McArdle N

    更新日期:2019-10-01 00:00:00

  • Diurnal changes of blood pressure, heart rate and body temperature during sleep in the rat.

    abstract::We have studied diurnal changes in mean arterial pressure (MAP), heart rate (HR) and body temperature (Tb) during wake (W), non-rapid eye movement sleep (NREMS) and REM sleep (REMS) in the rat. Although HR and Tb show a similar sinusoidal diurnal variation during all vigilance states, the diurnal profile for the MAP i...

    journal_title:Journal of sleep research

    pub_type: 杂志文章

    doi:10.1046/j.1365-2869.1997.00038.x

    authors: Sei H,Furuno N,Morita Y

    更新日期:1997-06-01 00:00:00

  • Effect of ambient temperature on arterial pressure variability during sleep in the rat.

    abstract::Changes in mean arterial pressure (MAP) and heart rate (HR) during sleep were recorded at three ambient temperatures (Ta: 16, 22 and 28 degrees C). MAP and HR during sleep increased with lowering of Ta. The increase in MAP during the transition from NREM to REM sleep was decreased by lowering the Ta. At 28 degrees C, ...

    journal_title:Journal of sleep research

    pub_type: 杂志文章

    doi:10.1046/j.1365-2869.1996.00007.x

    authors: Sei H,Morita Y

    更新日期:1996-03-01 00:00:00

  • The effect of complex cognitive training on subsequent night sleep.

    abstract::Using a nap design, we have recently shown that training at a complex cognitive task at bedtime improves objective sleep quality by reducing sleep fragmentation. In order to extend our findings to nighttime sleep, here we assess the impact of a multi-componential cognitive task at bedtime on the subsequent sleep episo...

    journal_title:Journal of sleep research

    pub_type: 杂志文章

    doi:10.1111/jsr.12929

    authors: Cerasuolo M,Conte F,Cellini N,Fusco G,Giganti F,Malloggi S,Ficca G

    更新日期:2020-12-01 00:00:00

  • Effects of long work hours and poor sleep characteristics on workplace injury among full-time male employees of small- and medium-scale businesses.

    abstract::The aim of this study was to investigate the effects of long work hours and poor sleep characteristics on workplace injury. A total of 1891 male employees, aged 18-79 years (mean 45 years), in 296 small- and medium-scale businesses in a suburb of Tokyo were surveyed by means of a self-administered questionnaire during...

    journal_title:Journal of sleep research

    pub_type: 杂志文章

    doi:10.1111/j.1365-2869.2011.00910.x

    authors: Nakata A

    更新日期:2011-12-01 00:00:00

  • Objectively measured night-to-night sleep variations are associated with body composition in very elderly women.

    abstract::This cross-sectional study examined the association between objectively measured sleep patterns and body composition in very elderly community-dwelling women. Participants included 191 community-dwelling adults aged ≥ 80 years (mean age: 83.4 ± 2.6 years; age range: 80-92 years). Sleep and physical activity were monit...

    journal_title:Journal of sleep research

    pub_type: 杂志文章

    doi:10.1111/jsr.12326

    authors: Kim M,Sasai H,Kojima N,Kim H

    更新日期:2015-12-01 00:00:00

  • Effect of rapid eye movement sleep deprivation on rat brain Na-K ATPase activity.

    abstract::Since rapid eye movement (REM) sleep deprivation has been reported to affect the neuronal excitability in the brain, it was hypothesized that a change in the neuronal membrane-bound Na-K ATPase activity might be at least one of the factors inducing such a change. Therefore, in this study rats were deprived of REM slee...

    journal_title:Journal of sleep research

    pub_type: 杂志文章

    doi:10.1111/j.1365-2869.1993.tb00060.x

    authors: Gulyani S,Mallick BN

    更新日期:1993-03-01 00:00:00

  • First-night effect on cardiac autonomic function in different female reproductive states.

    abstract::Decreases in heart rate variability, a marker of autonomic nervous system function, are associated with increased cardiovascular mortality. Heart rate variability increases in non-rapid eye movement sleep, peaking in slow-wave sleep. Therefore, decreasing the amount of deep sleep, for example, by introducing patients ...

    journal_title:Journal of sleep research

    pub_type: 杂志文章

    doi:10.1111/jsr.12560

    authors: Virtanen I,Kalleinen N,Urrila AS,Polo-Kantola P

    更新日期:2018-04-01 00:00:00

  • Exploring the impact of experimental sleep restriction and sleep deprivation on subjectively perceived sleep parameters.

    abstract::We aimed to investigate the effect of increased sleep pressure and shortened sleep duration on subjective sleep perception in relation to electroencephalographic sleep measures. We analyzed the data from a study in which 14 healthy male volunteers had completed a baseline assessment with 8 hr time in bed, a sleep depr...

    journal_title:Journal of sleep research

    pub_type: 杂志文章

    doi:10.1111/jsr.12706

    authors: Maric A,Bürgi M,Werth E,Baumann CR,Poryazova R

    更新日期:2019-06-01 00:00:00

  • Clinical significance of ventricular late potentials in patients with obstructive sleep apnoea.

    abstract::Patients with obstructive sleep apnoea (OSA) have an increased cardiovascular mortality and probably also an increased incidence of sudden cardiac death. Thus the question arises whether ventricular late potentials can constitute markers for an increased electric vulnerability in these patients. Signal-averaged electr...

    journal_title:Journal of sleep research

    pub_type: 杂志文章

    doi:10.1111/j.1365-2869.1995.tb00213.x

    authors: Sanner B,Konermann M,Hörstensmeyer D,Kreuzer I I,Burmann-Urbanek M

    更新日期:1995-06-01 00:00:00

  • Autobiographical memory impairment in obstructive sleep apnea patients with and without depressive symptoms.

    abstract::Obstructive sleep apnea is associated with memory impairments, and higher rates of depressive symptoms and major depressive disorder compared with community estimates. Autobiographical memory overgenerality, a behaviour characterized by difficulty recalling specific memories from one's own life, is recognized as a mar...

    journal_title:Journal of sleep research

    pub_type: 杂志文章

    doi:10.1111/jsr.12418

    authors: Lee VV,Trinder J,Jackson ML

    更新日期:2016-10-01 00:00:00

  • Physical activity, subjective sleep quality and time in bed do not vary by moon phase in German adolescents.

    abstract::Lunar periodicity in human biology and behaviour, particularly sleep, has been reported. However, estimated relationships vary in direction (more or less sleep with full moon) if they exist at all, and studies tend to be so small that there is potential for confounding by weekly or monthly cycles. Lunar variation in p...

    journal_title:Journal of sleep research

    pub_type: 杂志文章

    doi:10.1111/jsr.12472

    authors: Smith MP,Standl M,Schulz H,Heinrich J

    更新日期:2017-06-01 00:00:00

  • Chronic partial sleep deprivation reduces brain sensitivity to glutamate N-methyl-D-aspartate receptor-mediated neurotoxicity.

    abstract::It has been hypothesized that insufficient sleep may compromise neuronal function and contribute to neurodegenerative processes. While sleep loss by itself may not lead to cell death directly, it may affect the sensitivity to a subsequent neurodegenerative insult. Here we examined the effects of chronic sleep restrict...

    journal_title:Journal of sleep research

    pub_type: 杂志文章

    doi:10.1111/j.1365-2869.2011.00932.x

    authors: Novati A,Hulshof HJ,Granic I,Meerlo P

    更新日期:2012-02-01 00:00:00

  • Changes in sleepiness and body temperature precede nocturnal sleep onset: evidence from a polysomnographic study in young men.

    abstract::Recent research has shown a close temporal relationship between the nocturnal decrease in rectal core temperature and the initiation of sleep. However, there is not yet a clear temporal relationship between changes in peripheral and core temperatures and nocturnal sleep onset. We recorded body temperatures in 14 adult...

    journal_title:Journal of sleep research

    pub_type: 杂志文章

    doi:10.1046/j.1365-2869.1998.00112.x

    authors: van den Heuvel CJ,Noone JT,Lushington K,Dawson D

    更新日期:1998-09-01 00:00:00

  • The duration of REM sleep epic, odes in normal sleep.

    abstract::The distributions of the durations of the first 3 REM sleep episodes have been analysed using a total of 134 overnight sleep recordings from 10 subjects. From investigation of the length of uninterrupted episodes of stage REM, it is shown that arousals to stage 0/1 could play an important part in the process of REM ex...

    journal_title:Journal of sleep research

    pub_type: 杂志文章

    doi:10.1111/j.1365-2869.1992.tb00025.x

    authors: Belyavin AJ

    更新日期:1992-06-01 00:00:00

  • Time course of sleep inertia dissipation in human performance and alertness.

    abstract::Alertness and performance on a wide variety of tasks are impaired immediately upon waking from sleep due to sleep inertia, which has been found to dissipate in an asymptotic manner following waketime. It has been suggested that behavioural or environmental factors, as well as sleep stage at awakening, may affect the s...

    journal_title:Journal of sleep research

    pub_type: 杂志文章

    doi:10.1111/j.1365-2869.1999.00128.x

    authors: Jewett ME,Wyatt JK,Ritz-De Cecco A,Khalsa SB,Dijk DJ,Czeisler CA

    更新日期:1999-03-01 00:00:00

  • Slow-wave sleep: do young adult men and women age differently?

    abstract::The differential effects of ageing on polysomnographic and EEG spectral characteristics of sleep were explored in men and women between the ages of 20 and 40. Men and women in their twenties were found to have similar percentages of slow-wave sleep (SWS) (% Stage 3 and 4) and mean EEG slow wave activity (quantified by...

    journal_title:Journal of sleep research

    pub_type: 杂志文章

    doi:10.1046/j.1365-2869.1997.00041.x

    authors: Ehlers CL,Kupfer DJ

    更新日期:1997-09-01 00:00:00

  • The performance of critical flicker frequency on determining of neurocognitive function loss in severe obstructive sleep apnea syndrome.

    abstract::This study aimed to compare the critical flicker frequency (CFF) and the mail-in cognitive function screening ınstrument (MCFSI) tests' effectiveness in diagnosing neurocognitive function losses in patients having severe obstructive sleep apnea syndrome (OSAS). A total of 85 subjects (47 patients with a diagnosis of s...

    journal_title:Journal of sleep research

    pub_type: 杂志文章

    doi:10.1111/jsr.12531

    authors: Guzel A,Gunbey E,Koksal N

    更新日期:2017-10-01 00:00:00

  • Emotional facial expressions during REM sleep dreams.

    abstract::Although motor activity is actively inhibited during rapid eye movement (REM) sleep, specific activations of the facial mimetic musculature have been observed during this stage, which may be associated with greater emotional dream mentation. Nevertheless, no specific biomarker of emotional valence or arousal related t...

    journal_title:Journal of sleep research

    pub_type: 杂志文章

    doi:10.1111/jsr.12716

    authors: Rivera-García AP,López Ruiz IE,Ramírez-Salado I,González-Olvera JJ,Ayala-Guerrero F,Jiménez-Anguiano A

    更新日期:2019-02-01 00:00:00

  • Sleep patterns of European expatriates in a dry tropical climate.

    abstract::Night sleep in sedentary African subjects living in the sahelian zone lasts from 7 h to 8 h, with high amounts of slow-wave sleep (SWS) and paradoxical sleep (PS), SWS being present in each sleep cycle. We report here on sleep patterns in 6 healthy male European expatriates (aged 32-39 years) living in the same tropic...

    journal_title:Journal of sleep research

    pub_type: 杂志文章

    doi:10.1111/j.1365-2869.1992.tb00037.x

    authors: Montmayeur A,Buguet A

    更新日期:1992-09-01 00:00:00

  • Post-CPAP sleepiness--a specific syndrome?

    abstract::Following treatment with continuous positive airway pressure (CPAP), some patients with obstructive sleep apnoea (OSA) remain sleepy despite effective CPAP and attention to other diagnoses that can provoke sleepiness. It is unclear if this residual sleepiness is an irreversible result of their previous OSA and merits ...

    journal_title:Journal of sleep research

    pub_type: 杂志文章

    doi:10.1111/j.1365-2869.2007.00617.x

    authors: Stradling JR,Smith D,Crosby J

    更新日期:2007-12-01 00:00:00

  • The trait of Introversion-Extraversion predicts vulnerability to sleep deprivation.

    abstract::According to Eysenck's theory of Introversion-Extroversion (I-E), introverts demonstrate higher levels of basal activity within the reticular-thalamic-cortical loop, yielding higher tonic cortical arousal than Extraverts, who are described conversely as chronically under-aroused and easily bored. We hypothesized that ...

    journal_title:Journal of sleep research

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1365-2869.2007.00611.x

    authors: Killgore WD,Richards JM,Killgore DB,Kamimori GH,Balkin TJ

    更新日期:2007-12-01 00:00:00