Abstract：
:Patients with prefrontal cortex lesions are impaired on a variety of planning and problem-solving tasks. We examined the problem-solving performance of 27 patients with focal frontal lobe damage on the Water Jug task. The Water Jug task has never been used to assess problem-solving ability in neurologically impaired patients nor in functional neuroimaging studies, despite sharing structural similarities with other tasks sensitive to prefrontal cortex function, including the Tower of Hanoi, Tower of London, and Wisconsin Card Sorting Task (WCST). Our results demonstrate that the Water Jug task invokes a unique combination of problem-solving and planning strategies, allowing a more precise identification of frontal lobe lesion patients' cognitive deficits. All participants (patients and matched controls) appear to be utilizing a hill-climbing strategy that does not require sophisticated planning; however, frontal lobe lesion patients (FLLs) struggled to make required "counterintuitive moves" not predicted by this strategy and found within both solution paths. Left and bilateral FLLs were more impaired than right FLLs. Analysis of the left hemisphere brain regions encompassed by the lesions of these patients found that poor performance was linked to left dorsolateral prefrontal cortex damage. We propose that patients with left dorsolateral prefrontal cortex lesions have difficulty making a decision requiring the conceptual comparison of nonverbal stimuli, manipulation of select representations of potential solutions, and are unable to appropriately inhibit a response in keeping with the final goal.
journal_name
J Cogn Neuroscijournal_title
Journal of cognitive neuroscienceauthors
Colvin MK,Dunbar K,Grafman Jdoi
10.1162/089892901753294419subject
Has Abstractpub_date
2001-11-15 00:00:00pages
1129-47issue
8eissn
0898-929Xissn
1530-8898journal_volume
13pub_type
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journal_title：Journal of cognitive neuroscience
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abstract：:In this article we report some findings about visual imagery in patients with stable homonymous hemianopia compared to healthy control subjects. These findings were obtained by analyzing the gaze control through recording of eye movements in different phases of viewing and imagery. We used six different visual stimuli...
journal_title：Journal of cognitive neuroscience
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doi：10.1162/jocn_a_00254
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journal_title：Journal of cognitive neuroscience
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journal_title：Journal of cognitive neuroscience
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journal_title：Journal of cognitive neuroscience
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journal_title：Journal of cognitive neuroscience
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journal_title：Journal of cognitive neuroscience
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journal_title：Journal of cognitive neuroscience
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journal_title：Journal of cognitive neuroscience
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journal_title：Journal of cognitive neuroscience
pub_type： 杂志文章
doi：10.1162/jocn.2007.19.1.25
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journal_title：Journal of cognitive neuroscience
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doi：10.1162/jocn_a_00835
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journal_title：Journal of cognitive neuroscience
pub_type： 杂志文章
doi：10.1162/jocn.2010.21494
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journal_title：Journal of cognitive neuroscience
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doi：10.1162/089892901564306
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journal_title：Journal of cognitive neuroscience
pub_type： 杂志文章
doi：10.1162/jocn.2008.21180
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journal_title：Journal of cognitive neuroscience
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doi：10.1162/jocn_a_00315
更新日期：2013-01-01 00:00:00
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journal_title：Journal of cognitive neuroscience
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doi：10.1162/jocn.2009.21279
更新日期：2010-02-01 00:00:00
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journal_title：Journal of cognitive neuroscience
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journal_title：Journal of cognitive neuroscience
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journal_title：Journal of cognitive neuroscience
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journal_title：Journal of cognitive neuroscience
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doi：10.1162/jocn.2009.21321
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journal_title：Journal of cognitive neuroscience
pub_type： 杂志文章
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journal_title：Journal of cognitive neuroscience
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更新日期：2002-10-01 00:00:00
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journal_title：Journal of cognitive neuroscience
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doi：10.1162/jocn_a_01606
更新日期：2020-11-01 00:00:00
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journal_title：Journal of cognitive neuroscience
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更新日期：1998-11-01 00:00:00
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journal_title：Journal of cognitive neuroscience
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doi：10.1162/jocn.2008.20051
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