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Carbon-carbon-linked (pyrazolylphenyl)oxazolidinones with antibacterial activity against multiple drug resistant gram-positive and fastidious gram-negative bacteria.

Abstract：

:In an effort to expand the spectrum of activity of the oxazolidinone class of antibacterial agents to include Gram-negative bacteria, a series of new carbon-carbon linked pyrazolylphenyl analogues has been prepared. The alpha-N-substituted methyl pyrazole (10alpha) in the C3-linked series exhibited very good Gram-positive activity with MICs

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Lee CS,Allwine DA,Barbachyn MR,Grega KC,Dolak LA,Ford CW,Jensen RM,Seest EP,Hamel JC,Schaadt RD,Stapert D,Yagi BH,Zurenko GE,Genin MJ

doi

10.1016/s0968-0896(01)00233-4

subject

Has Abstract

pub_date

2001-12-01 00:00:00

pages

3243-53

issue

12

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(01)00233-4

journal_volume

9

pub_type

杂志文章

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