Weight and body composition in a cohort of HIV-positive men and women.

Abstract:

OBJECTIVE:At issue is whether weight loss in HIV infection is a cachectic process, characterised by loss of lean body mass with conservation of fat, or a process of starvation. We present data on body composition from 516 persons at different stages of HIV infection as determined by CD4 counts. DESIGN:Cross-sectional analyses of body composition in relation to CD4 count. SETTING:The baseline data from a prospective cohort study of outcomes in HIV/AIDS in relation to nutritional status in Boston, Massachusetts, USA. SUBJECTS:: The first 516 subjects with HIV/AIDS to enroll in the study. RESULTS:Differences in weight in relation to CD4 counts were present only at CD4 counts of 600 or less (slope below : 1.9 kg per 100 CD4 cells, On average, 68% of the difference in weight over CD4 counts was fat (slope: 1.3 kg fat per 100 CD4 cells, CONCLUSIONS:This cross-sectional analysis suggests that weight loss consists principally of fat loss in those persons with adequate fat stores. This observation will need to be confirmed in longitudinal analyses.

journal_name

Public Health Nutr

journal_title

Public health nutrition

authors

Forrester JE,Spiegelman D,Woods M,Knox TA,Fauntleroy JM,Gorbach SL

doi

10.1079/phn200099

subject

Has Abstract

pub_date

2001-06-01 00:00:00

pages

743-7

issue

3

eissn

1368-9800

issn

1475-2727

pii

S1368980001000684

journal_volume

4

pub_type

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