Abstract：
:A blinded meta analysis was performed on randomized clinical trials (RCT) on the medicinal treatment of reflex sympathetic dystrophy (complex regional pain syndrome type I) to assess the methodological quality and quantify the analgesic effect of treatments by calculating individual and summary effect sizes. The internal validity of 21 RCTs was investigated and the quality weighted summary effect size was calculated using a fixed effect model (Glass Delta). The methodological quality ranged from moderate to good (average 46%). Differences were found between the trials in inclusion/exclusion criteria, treatment methods, duration of treatments and trials, and measurement instruments. Statistical analysis was possible for four subgroups; one evaluating the analgesic effects of sympathetic suppressors in general (n = 12), one subgroup concerning the analgesic effects of guanethidine (n = 6), one investigating the analgesic effect of intravenous regional sympathetic blocks (n = 9), and one subgroup (n = 5) evaluating the analgesic effect of calcitonin. Except for the calcitonin subgroup (P = 0.002), the quality-weighted summary effect size of these subgroups were not significant. No significant analgesic effect by sympathetic suppressing agents could be established. Calcitonin seems to provide effective pain relief in reflex sympathetic dystrophy patients. The results of the present study show that weighting methodological quality influences the magnitude of the effect sizes of specific treatment methods. Future studies should control for methodological quality.
journal_name
J Pain Symptom Managejournal_title
Journal of pain and symptom managementauthors
Perez RS,Kwakkel G,Zuurmond WW,de Lange JJdoi
10.1016/s0885-3924(01)00282-2subject
Has Abstractpub_date
2001-06-01 00:00:00pages
511-26issue
6eissn
0885-3924issn
1873-6513pii
S0885392401002822journal_volume
21pub_type
杂志文章,meta分析abstract：:Thoracentesis plays an important role in cancer patients with symptomatic effusions, although its effect is short-lived and symptoms recur in almost all patients. Early video-thoracoscopic surgical pleurodesis may provide added benefit to a group of patients with advanced cancer presenting with symptomatic malignant p...
journal_title：Journal of pain and symptom management
pub_type： 临床试验,杂志文章
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abstract：:Recent research has shown that the psychostimulant drug dextroamphetamine can increase the analgesia produced by opioids. Despite the strong, positive results in human clinical subjects and in animals, this combination is rarely used in clinical practice. The purpose of this paper is to investigate whether the psychos...
journal_title：Journal of pain and symptom management
pub_type： 杂志文章
doi：10.1016/s0885-3924(98)00085-2
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journal_title：Journal of pain and symptom management
pub_type： 杂志文章,随机对照试验
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journal_title：Journal of pain and symptom management
pub_type： 杂志文章
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journal_title：Journal of pain and symptom management
pub_type： 杂志文章,meta分析
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更新日期：2012-12-01 00:00:00
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journal_title：Journal of pain and symptom management
pub_type： 杂志文章
doi：10.1016/j.jpainsymman.2011.11.010
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journal_title：Journal of pain and symptom management
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journal_title：Journal of pain and symptom management
pub_type： 杂志文章
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journal_title：Journal of pain and symptom management
pub_type： 杂志文章,评审
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journal_title：Journal of pain and symptom management
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jpainsymman.2014.04.006
更新日期：2014-12-01 00:00:00
abstract：CONTEXT:Fatigue is one of the most common symptoms reported by cancer survivors, and fatigue worsens when patients are engaged in muscle exertion, which results in early motor task failure. Central fatigue plays a significant role, more than muscle (peripheral) fatigue, in contributing to early task failure in cancer-r...
journal_title：Journal of pain and symptom management
pub_type： 杂志文章
doi：10.1016/j.jpainsymman.2011.08.007
更新日期：2012-09-01 00:00:00
abstract：:To define changes in sleep and subjective fatigue associated with localized radiation treatment, and to determine their relationship to interleukin-1B (IL-1), we prospectively followed 15 men, none of whom were depressed during 8 wk of radiation treatment for localized prostate cancer. Each patient rated fatigue daily...
journal_title：Journal of pain and symptom management
pub_type： 临床试验,杂志文章
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更新日期：1993-05-01 00:00:00
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journal_title：Journal of pain and symptom management
pub_type： 杂志文章
doi：10.1016/j.jpainsymman.2008.04.013
更新日期：2009-04-01 00:00:00
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journal_title：Journal of pain and symptom management
pub_type： 杂志文章
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journal_title：Journal of pain and symptom management
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1997-05-01 00:00:00
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journal_title：Journal of pain and symptom management
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.jpainsymman.2010.06.015
更新日期：2011-04-01 00:00:00
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journal_title：Journal of pain and symptom management
pub_type： 杂志文章
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journal_title：Journal of pain and symptom management
pub_type： 杂志文章
doi：10.1016/s0885-3924(01)00392-x
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journal_title：Journal of pain and symptom management
pub_type： 杂志文章
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journal_title：Journal of pain and symptom management
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journal_title：Journal of pain and symptom management
pub_type： 杂志文章,随机对照试验
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journal_title：Journal of pain and symptom management
pub_type： 杂志文章
doi：10.1016/j.jpainsymman.2008.01.008
更新日期：2009-02-01 00:00:00
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journal_title：Journal of pain and symptom management
pub_type： 杂志文章
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更新日期：2004-07-01 00:00:00
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journal_title：Journal of pain and symptom management
pub_type： 杂志文章
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更新日期：2020-08-21 00:00:00
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journal_title：Journal of pain and symptom management
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更新日期：2014-11-01 00:00:00
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journal_title：Journal of pain and symptom management
pub_type： 杂志文章
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更新日期：2003-12-01 00:00:00
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journal_title：Journal of pain and symptom management
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更新日期：2013-07-01 00:00:00
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journal_title：Journal of pain and symptom management
pub_type： 杂志文章
doi：10.1016/j.jpainsymman.2012.01.010
更新日期：2013-01-01 00:00:00
abstract：:This trial compared pain, quality of life, and analgesic use in a sample of patients with cancer pain (n=24) who received either standard opioid management plus rest (Arm A) or standard opioid management plus Reiki (Arm B). Participants either rested for 1.5 hr on Days 1 and 4 or received two Reiki treatments (Days 1 ...
journal_title：Journal of pain and symptom management
pub_type： 临床试验,杂志文章
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更新日期：2003-11-01 00:00:00
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journal_title：Journal of pain and symptom management
pub_type： 杂志文章
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