Detection of mitochondrial DNA mutations in human gingival tissues.

Abstract:

:The accumulation of mitochondrial DNA mutation is an important contributor to the aging process. Polymerase chain reaction (PCR) amplification was carried out on total DNA from gingival tissues of human subjects with ages of 19 to 64 years, and 5.0-kb and 7.4-kb deletions were found in the mitochondrial genomes of these subjects. This is the first report of mitochondrial DNA deletion detectable in human gingival tissues.

journal_name

J Oral Sci

journal_title

Journal of oral science

authors

Sugano N,Kawamoto K,Numazaki H,Murai S,Ito K

doi

10.2334/josnusd.42.221

subject

Has Abstract

pub_date

2000-12-01 00:00:00

pages

221-3

issue

4

eissn

1343-4934

issn

1880-4926

journal_volume

42

pub_type

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