Expression of the IGF-1, IGFBP-3 and IGF-1 receptors in dental pulp stem cells and impacted third molars.

Abstract:

:IGF-1 regulates the metabolism of hard dental tissue through binding to the IGF-1 receptor on target cells. Furthermore, IGF-binding-protein-3 promotes the accessibility of IGF-1. The aim of this study was to investigate the expression of IGF-1, IGFBP-3 and IGF-1R in STRO-1-positive dental pulp stem cells (DPSCs) and fully impacted wisdom teeth in relation to tooth development. Third molars were surgically removed from 60 patients and classified into two groups: teeth showing ongoing development (group 1) and teeth that had completed root shaping (group 2). The transcript and protein levels of IGF-1, IGFBP-3 and IGF-1R were investigated using RT-PCR and immunohistochemistry. The expression of the same proteins was also analyzed in DPSCs. The teeth from group 1 showed significantly stronger expression of IGF-1 and IGF-1R. The major sources of all of the proteins investigated immunohistochemically in sections of wisdom teeth were odontoblasts, cementoblasts and cell colonies in the pulpal mesenchyme. These colonies were identified as stem cells in view of their positivity for STRO-1, and the cells were subsequently sorted by flow cytometry. These DPSCs demonstrated high levels of pluripotency markers and IGF-1 and IGF-1R. We conclude that members of the IGF-1 family are involved in the late stage of tooth development and the process of pulpal differentiation.

journal_name

J Oral Sci

journal_title

Journal of oral science

authors

Magnucki G,Schenk U,Ahrens S,Navarrete Santos A,Gernhardt CR,Schaller HG,Hoang-Vu C

doi

10.2334/josnusd.55.319

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

319-27

issue

4

eissn

1343-4934

issn

1880-4926

pii

DN/JST.JSTAGE/josnusd/55.319

journal_volume

55

pub_type

杂志文章
  • Vanishing mandible.

    abstract::Massive osteolysis is a rare, insidious, chronic disease characterized by progressive resorption of contiguous osseous structures. In 1838 Jackson first described a case of disappearing humerus. More than 150 cases have since been described in the international literature, with fewer then 35 involving a maxillofacial ...

    journal_title:Journal of oral science

    pub_type: 杂志文章

    doi:10.2334/josnusd.52.513

    authors: Sharma A,Iyer N,Mittal A,Das D,Sharma S

    更新日期:2010-09-01 00:00:00

  • Effect of modified tray design on accuracy of different impression techniques for parallel and divergent implants.

    abstract::This study evaluated the effect of a modified tray design on the accuracy of implant impressions in comparison with the non-splinted and splinted impression techniques. Two titanium frameworks were produced to fit two parallel implants and two divergent implants with a 15o angle. According to the frameworks employed, ...

    journal_title:Journal of oral science

    pub_type: 杂志文章

    doi:10.2334/josnusd.19-0482

    authors: Dang L,Woliansky M,Palamara J,Abduo J

    更新日期:2020-09-26 00:00:00

  • Time-dependent responses in brain activity to ongoing hot stimulation in burning mouth syndrome.

    abstract::Burning mouth syndrome (BMS) is classified into idiopathic orofacial pain conditions. Although central and peripheral neuropathic mechanisms are believed to be involved, the etiology remains to be fully elucidated. The present study examined temporal brain responses to an ongoing hot stimulus to investigate the pain m...

    journal_title:Journal of oral science

    pub_type: 杂志文章

    doi:10.2334/josnusd.18-0431

    authors: Kohashi R,Shinozaki T,Sekine N,Watanabe K,Takanezawa D,Nishihara C,Ozasa K,Ikeda M,Noma N,Okada-Ogawa A,Imamura Y

    更新日期:2020-01-01 00:00:00

  • Primary intraosseous carcinoma arising from an odontogenic cyst: a case report and review of the Japanese cases.

    abstract::A rare case of primary intraosseous carcinoma (PIOC) arising from an odontogenic cyst in a 58-year-old man is reported. Clinical and radiological examinations revealed an odontogenic cyst of the maxilla. Histopathologically, the lesion was composed of a cyst with a parakeratotic epithelial lining and well-differentiat...

    journal_title:Journal of oral science

    pub_type: 杂志文章,评审

    doi:10.2334/josnusd.44.49

    authors: Saito T,Okada H,Akimoto Y,Yamamoto H

    更新日期:2002-03-01 00:00:00

  • Is there evidence of a sphincter system in Wharton's duct? Etiological factors related to sialolith formation.

    abstract::The exact cause of the formation of sialoliths is unknown. Detailed knowledge of the pathogenesis of sialolithiasis is necessary to define new therapeutic procedures. The possible presence of a sphincter system in Wharton's duct has been described frequently in the context of diagnostic sialendoscopy. Serial histologi...

    journal_title:Journal of oral science

    pub_type: 杂志文章

    doi:10.2334/josnusd.45.233

    authors: Teymoortash A,Ramaswamy A,Werner JA

    更新日期:2003-12-01 00:00:00

  • Correlation of salivary and serum IgG, IgA levels with total protein in oral submucous fibrosis.

    abstract::Oral submucous fibrosis (OSMF) is a disabling, potentially malignant condition of the oral cavity. The aetiology of OSMF is multifactorial but remains obscure. Although arecanut is considered to be the most important causative agent, responses observed in individuals using arecanut vary in relation to quantity and dur...

    journal_title:Journal of oral science

    pub_type: 杂志文章

    doi:10.2334/josnusd.53.97

    authors: Patidar KA,Parwani RN,Wanjari SP

    更新日期:2011-03-01 00:00:00

  • The effects of estrogen on temporomandibular joint pain as influenced by trigeminal caudalis neurons.

    abstract::The signs and symptoms of persistent temporomandibular joint (TMJ)/muscle disorder (TMJD) pain suggest the existence of a central neural dysfunction or a problem of pain amplification. The etiology of chronic TMJD is not known; however, female sex hormones have been identified as significant risk factors. Converging l...

    journal_title:Journal of oral science

    pub_type: 杂志文章,评审

    doi:10.2334/josnusd.19-0405

    authors: Tashiro A,Bereiter DA

    更新日期:2020-03-28 00:00:00

  • Polymorphism in the Msx1 gene associated with hypodontia in a Brazilian family.

    abstract::Tooth development is regulated by a reciprocal series of epithelial-mesenchymal interactions. With the large number of genes involved in the odontogenesis process, the opportunity for mutations to disrupt this process is high. Mutational analysis has revealed genes that are major causes of non-syndromic hypodontia. Th...

    journal_title:Journal of oral science

    pub_type: 杂志文章

    doi:10.2334/josnusd.51.341

    authors: Silva ER,Reis-Filho CR,Napimoga MH,Alves JB

    更新日期:2009-09-01 00:00:00

  • Role of HMGB1 in proliferation and migration of human gingival and periodontal ligament fibroblasts.

    abstract::High mobility group box 1 (HMGB1) was originally defined as a nuclear protein. However, later studies showed that HMGB1 was released from damaged cells into the extracellular milieu and functioned as a danger signaling molecule. HMGB1 has also been shown to exert proliferative and chemoattractant effects on many cell ...

    journal_title:Journal of oral science

    pub_type: 杂志文章

    doi:10.2334/josnusd.55.45

    authors: Chitanuwat A,Laosrisin N,Dhanesuan N

    更新日期:2013-03-01 00:00:00

  • Effect of metal conditioners on polymerization behavior of bonding agents.

    abstract::This study aimed to determine the influence of metal conditioners on the polymerization behavior of bonding agents. Bonding agents of two-step self-etching primer systems and metal conditioners for adhesion of dental metal alloys were used. Double bond conversion was determined by Fourier transform-ation infrared spec...

    journal_title:Journal of oral science

    pub_type: 杂志文章

    doi:10.2334/josnusd.47.171

    authors: Yoshida T,Yamaguchi K,Tsubota K,Takamizawa T,Kurokawa H,Rikuta A,Ando S,Miyazaki M

    更新日期:2005-12-01 00:00:00

  • Biological plaque control: novel therapeutic approach to periodontal disease.

    abstract::Despite its important role in the control of periodontal disease, mechanical plaque control is not properly practiced by most individuals. Therefore, adjunctive chemical plaque control using chlorhexidine and antibiotics has also been suggested as an additional therapeutic strategy to augment mechanical plaque control...

    journal_title:Journal of oral science

    pub_type: 杂志文章,评审

    doi:10.2334/josnusd.54.1

    authors: Sugano N

    更新日期:2012-03-01 00:00:00

  • Telomeres on chromosome 21 and aging in lymphocytes and gingival fibroblasts from individuals with Down syndrome.

    abstract::Progressive chromosome 21 loss in individuals with trisomy 21 or Down syndrome (DS) is supposedly related to their premature senescence. In addition, the telomere hypothesis of cellular aging involving telomere shortening in normal and accelerated aging in vivo and in vitro is well documented. This study investigated ...

    journal_title:Journal of oral science

    pub_type: 杂志文章

    doi:10.2334/josnusd.46.171

    authors: de Arruda Cardoso Smith M,Borsatto-Galera B,Feller RI,Gonçalves A,Oyama RS,Segato R,Chen E,Carvalheira GM,Filho AS,Burbano RR,Payão SL

    更新日期:2004-09-01 00:00:00

  • Satisfaction with dietary life affects oral health-related quality of life and subjective well-being in very elderly people.

    abstract::Age-related deterioration in physical and oral health reduces healthy life expectancy and is thus an important problem for very elderly people. We investigated the effects of satisfaction with dietary life (SDL) in everyday life on oral health-related quality of life (OHRQoL) and subjective well-being and examined ass...

    journal_title:Journal of oral science

    pub_type: 杂志文章

    doi:10.2334/josnusd.16-0414

    authors: Iinuma T,Arai Y,Takayama M,Takayama M,Abe Y,Osawa Y,Fukumoto M,Fukui Y,Shioda Y,Hirose N,Komiyama K,Gionhaku N

    更新日期:2017-01-01 00:00:00

  • Concentration of 137Cs in dried Lentinula edodes (Shiitake) as an indicator of environmental contamination.

    abstract::We analysed the concentration of radioactive cesium in dried Lentinula edodes (Shiitake) produced in Japan, and evaluated its use as an indicator of radioactive contamination. We collected Lentinula edodes (Shiitake) mushrooms grown on wood in 38 prefectures from north to south, and measured 137Cs, 134Cs and 40K conce...

    journal_title:Journal of oral science

    pub_type: 杂志文章

    doi:10.2334/josnusd.43.145

    authors: Shimizu M,Anzai I

    更新日期:2001-06-01 00:00:00

  • Congenital absence of the permanent canines: a clinico-statistical study.

    abstract::We report here a clinico-statistical study of congenital absence of the permanent canines (CAPC). Sixty-five cases (22 men and 43 women) of CAPC were found in the files of 35,927 outpatients, an incidence of 0.18%. Thirty-seven cases had single absence of the canine and 28 cases had multiple absences. There were 42 ca...

    journal_title:Journal of oral science

    pub_type: 杂志文章

    doi:10.2334/josnusd.46.247

    authors: Fukuta Y,Totsuka M,Takeda Y,Yamamoto H

    更新日期:2004-12-01 00:00:00

  • Detection of Epstein-Barr virus and human cytomegalovirus in blood and oral samples: comparison of three sampling methods.

    abstract::The purpose of this study was to identify and compare the presence of HCMV and EBV-1 in subgingival plaque, unstimulated saliva and peripheral blood of patients with chronic periodontitis. Forty patients diagnosed with chronic periodontitis (mean age, 41.7 years) were recruited. Unstimulated saliva, subgingival plaque...

    journal_title:Journal of oral science

    pub_type: 杂志文章

    doi:10.2334/josnusd.50.25

    authors: Imbronito AV,Grande SR,Freitas NM,Okuda O,Lotufo RF,Nunes FD

    更新日期:2008-03-01 00:00:00

  • Compliance with supportive periodontal therapy among patients with aggressive and chronic periodontitis.

    abstract::Compliance with supportive periodontal therapy (SPT) depends on many factors but is generally poor. We compared SPT compliance among patients with aggressive and chronic periodontitis. This single-center longitudinal observational study enrolled 101 patients with generalized aggressive periodontitis (GAP; n = 52) or g...

    journal_title:Journal of oral science

    pub_type: 杂志文章

    doi:10.2334/josnusd.57.249

    authors: Agrawal N,Jain R,Jain M,Agarwal K,Dubey A

    更新日期:2015-09-01 00:00:00

  • Effect of ammonium hexafluorosilicate application for arresting caries treatment on demineralized primary tooth enamel.

    abstract::Ammonium hexafluorosilicate (AHF) has been applied to arrest caries without discoloration. The purpose of this study was to observe structural and elemental changes of demineralized and AHF applied primary tooth enamel. Enamel from the labial surface of 20 primary canines was divided into an unground side and ground s...

    journal_title:Journal of oral science

    pub_type: 杂志文章

    doi:10.2334/josnusd.55.115

    authors: Hosoya Y,Tadokoro K,Otani H,Hidaka K,Inoue T,Miyazaki M,Tay FR

    更新日期:2013-01-01 00:00:00

  • Fluoride content in plaque solids and fluid after ingestion of fluoridated milk.

    abstract::This study explored differences in dental biofilm solids and fluid fluoride after ingestion of NaF or Na2FPO3 in milk or non-fluoridated milk. Eighteen volunteers ingested 1 mg fluoride in 200 mL of milk or 200 mL of non-fluoridated milk. Biofilm samples were collected at baseline, 30, 60, and 240 min and biofilm soli...

    journal_title:Journal of oral science

    pub_type: 杂志文章

    doi:10.2334/josnusd.55.233

    authors: Martínez-Mier EA,Soto-Rojas AE,Buckley C,Weitz A,Villa A,Zero DT

    更新日期:2013-09-01 00:00:00

  • Single-session use of mineral trioxide aggregate as an apical barrier in a case of external root resorption.

    abstract::External root resorption may occur as a consequence of trauma, orthodontic treatment, bacterial infection or incomplete sealing of the root canal system (bacterial re-infection), and lead to crater formation on the resorbed apex. This would deform the root apex surface, and cause loss of apical constriction. Depending...

    journal_title:Journal of oral science

    pub_type: 杂志文章

    doi:10.2334/josnusd.52.325

    authors: Araújo RA,Silveira CF,Cunha RS,De Martin AS,Fontana CE,Bueno CE

    更新日期:2010-06-01 00:00:00

  • Application of CT imaging for dental implant simulation.

    abstract::Accurate diagnosis and exact treatment planning are very important for successful implant treatment. Pretreatment examination and simulations using CT can be especially effective information sources, and diagnosis by CT imaging before treatment substantially enhances the security and safety of the treatment plan. New ...

    journal_title:Journal of oral science

    pub_type: 杂志文章

    doi:10.2334/josnusd.41.157

    authors: Hagiwara Y,Koizumi M,Igarashi T

    更新日期:1999-12-01 00:00:00

  • Susceptibility of Enterococcus faecalis biofilm to antibiotics and calcium hydroxide.

    abstract::The purpose of this study was to investigate the antimicrobial efficacy of six groups of antibiotics and calcium hydroxide against Enterococcus faecalis biofilm in a membrane filter model. Two-day-old E. faecalis (ATCC 29212) biofilm was exposed to ampicillin, co-trimoxazole, erythr omycin, oxytetracycline, vancomycin...

    journal_title:Journal of oral science

    pub_type: 杂志文章

    doi:10.2334/josnusd.49.161

    authors: Chai WL,Hamimah H,Cheng SC,Sallam AA,Abdullah M

    更新日期:2007-06-01 00:00:00

  • Treatment of large ameloblastic fibroma: a case report.

    abstract::Ameloblastic fibroma (AF) is an extremely rare true mixed benign tumor that can occur in either the mandible or the maxilla, but is most frequently found in the posterior region of the mandible. It usually occurs in the first two decades of life and is associated with tooth enclosure, causing a delay in eruption or al...

    journal_title:Journal of oral science

    pub_type: 杂志文章

    doi:10.2334/josnusd.51.293

    authors: Vasconcelos BC,Andrade ES,Rocha NS,Morais HH,Carvalho RW

    更新日期:2009-06-01 00:00:00

  • Oral clefts: a retrospective study of prevalence and predisposal factors in the State of Mexico.

    abstract::The purpose of this study was to up-date the records concerning oral clefts (OCs) encountered at the Child Hospital of the Maternal Infantile Institute of the State of México, and to examine the association of predisposing factors. A retrospective study of the medical records of patients generated over a 5-year period...

    journal_title:Journal of oral science

    pub_type: 杂志文章

    doi:10.2334/josnusd.50.123

    authors: González BS,López ML,Rico MA,Garduño F

    更新日期:2008-06-01 00:00:00

  • Oral recurrent aphthous ulcers/stomatitis: prevalence in Malaysia and an epidemiological update.

    abstract::One of the objectives of this short communication was to add to the literature on the prevalence of oral recurrent aphthous stomatitis (ORAS). This research is based on a total of 11,697 randomly selected Malaysian subjects with an age range of 25-115 years and a mean age of 44.5 +/- 13.9 years who were examined for o...

    journal_title:Journal of oral science

    pub_type: 杂志文章

    doi:10.2334/josnusd.42.15

    authors: Zain RB

    更新日期:2000-03-01 00:00:00

  • Orthodontic concerns of Brazilian children and their parents compared to the normative treatment need.

    abstract::The objective of the present study was to evaluate the interest of both children and parents towards orthodontic treatment and compare it to the normative treatment need as well as to determine the factors related to such an interest. The sample consisted of 407 schoolchildren aged between 9 and 12 years and their par...

    journal_title:Journal of oral science

    pub_type: 杂志文章

    doi:10.2334/josnusd.52.101

    authors: Dias PF,Gleiser R

    更新日期:2010-03-01 00:00:00

  • Surgical treatment of enophthalmos in children and adolescents with pure orbital blowout fracture.

    abstract:PURPOSE:This study evaluated outcomes of surgical treatment for enophthalmos after pediatric orbital blowout fracture. Associations of fracture type, fracture site, time from injury to treatment, and type of surgical procedure with treatment outcomes were assessed. METHODS:The medical records of 200 children and adole...

    journal_title:Journal of oral science

    pub_type: 杂志文章

    doi:10.2334/josnusd.20-0371

    authors: Koryczan P,Zapała J,Gontarz M,Wyszyńska-Pawelec G

    更新日期:2020-12-28 00:00:00

  • Histopathologic evaluation of subcutaneous tissue response to three endodontic sealers in rats.

    abstract::The aim of this study was to evaluate the subcutaneous biocompatibility of three root canal sealers in rats. Thirty Wistar rats were divided into three groups according to three time periods (15, 30 and 60 days). Sterilized polyethylene tubes filled with root canal sealers (AH Plus, Epiphany & Grossman), and one empty...

    journal_title:Journal of oral science

    pub_type: 杂志文章

    doi:10.2334/josnusd.53.15

    authors: Farhad AR,Hasheminia S,Razavi S,Feizi M

    更新日期:2011-03-01 00:00:00

  • Efficacy of 'Gamadent' toothpaste on the healing of gingival tissues: a preliminary report.

    abstract::The aim of this randomised, parallel, double-blind study, in which 28 adult patients diagnosed with chronic gingivitis or early stages of chronic periodontitis were recruited, was to evaluate the efficacy of 'Gamadent' toothpaste compared to a placebo toothpaste. 'Gamadent' toothpaste has all the basic constituents of...

    journal_title:Journal of oral science

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2334/josnusd.45.153

    authors: Taiyeb-Ali TB,Zainuddin SL,Swaminathan D,Yaacob H

    更新日期:2003-09-01 00:00:00

  • Effects of selenium on the structure of the mandible in experimental diabetics.

    abstract::In the treatment of diabetes-induced pathologies, beneficial results have been obtained with administration of antioxidants. Selenium is an antioxidant and essential trace element in living organisms. The aim of this study was to investigate the possible effects of selenium on the structural alterations of the mandibl...

    journal_title:Journal of oral science

    pub_type: 杂志文章

    doi:10.2334/josnusd.44.85

    authors: Delilbasi C,Demiralp S,Turan B

    更新日期:2002-06-01 00:00:00